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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 3 | Coating characteristics and tribological properties of sputterdeposited MoS2/metal composite coatings deposited by closed field unbalanced magnetron sputter ion plating显示文摘 | Renevier N M Fox V C Teer D G | 2000 | Surface and Coatings Technology2000，127，： | 2 |
| 4 | Efficacy of me-mantine on behavioral and psychological symptoms related to dementia:a systematic meta-analysis显示文摘 | MAIDMENT I D FOX C G BOUSTANI M | 2008 | Ann Pharmacother2008，42，1： | 1 |
| 5 | A real-time particle filters显示文摘 | Kwok C Fox D Meil M | 2004 | Proceedings of the IEEE2004，92，3： | 1 |
| 6 | Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans显示文摘 | Fox D S Cruz M C Sia R A L | 2001 | Molecular Microbiology2001，39，： | 1 |
| 7 | Fractal feature analysis and classification in medical imaging显示文摘 | CHEN Chi-chang Daponte J S Fox M D | 1989 | IEEE Transactions on Medical Imaging1989，8，2： | 1 |
| 8 | A function blocking abti-mouse integrin aipha5betal antibody inhibits angio- genesis and impedes tumor growth in vivo显示文摘 | Bhaskar V Zhang D Fox M | 2007 | J Transl Med2007，5，： | 1 |
| 9 | Recurrence of primary breast lymphoma in contralateral breast:case report and review of the literature显示文摘 | Earnest R E Downey D M Fox J P | | 0，，05： | 1 |
| 10 | Evaluation of a novel antiplatelet agent for secondary prevention in patients with a history of atherosclerotic disease: Design and rationale for the Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events(TRA 2°P)-TIMI 50 trial 显示文摘 | MORROW D A SCIRICA B M FOX K A | 2009 | Am Heart J2009，158，3： | 1 |
| 11 | Determination of the in situ forces in the human posterior cruciate ligament using robotic technology 显示文摘 | Fox R J Harner C D Sakane M | 1998 | American Journal of Sports and Medicine1998，26，： | 1 |
| 12 | Real-time particle filters 显示文摘 | KWORK C FOX D MEILA M | 2004 | Proceedings of the IEEE2004，92，3： | 1 |
| 13 | DNA damage, poly (ADP-ribosyl) ation and apoptotic cell death as a potential common pathway of cytotoxic drug action显示文摘 | Marks D I Fox R M | 1991 | Biochemical pharmacology1991，42，10： | 1 |
| 14 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 15 | Real-time particle filters显示文摘 | KWOK C FOX D MEILA M | 2004 | Proceedings of the IEEE2004，92，3： | 1 |
| 16 | Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms显示文摘 | Fox A J Vinuela F Pelz D M | 1987 | J Neurosurg1987，66，1： | 1 |
| 17 | Principal mechanisms of damping in cast iron 显示文摘 | Adams R D Fox M A O | 1973 | Journal of the Iron and Steel Institute1973，，7： | 1 |
| 18 | A real-time particle filters 显示文摘 | Kwok C Fox D Meil M | 2004 | Proceedings of the IEEE2004，92，3： | 1 |
| 19 | The role of soil surface crusting in desertification and strategies to reduce crusting显示文摘 | Fox D M Bryan R B Price A G | 2004 | Environmental Monitoring and Assessment2004，99，13： | 1 |
| 20 | A cardiac prevention and rehabilitation programme for all patients at first presentation with coronary artery disease显示文摘 | Fox K F Nuttall M Wood D A | | 0，，05： | 1 |
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