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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Active iron species in the catalytic wet peroxide oxidation of phenol over pillared clays containing iron显示文摘 | Guelou E Barrault J Fournier J | 2003 | Applied Catalysis B2003，44，： | 1 |
| 3 | Polyvinyl alcohol-coated macroporous polystyrene particles as stationary phases for the chromatography of protein 显示文摘 | Leonard M Fournier C Dellacherie E | 1995 | Journal of Chromatography B1995，664，： | 1 |
| 4 | Patients with isola- ted hip fracture must be considered for surgery irrespective- ly of their age, comorbidity status and provenance : a state- ment applicable even to nonagerians 显示文摘 | Bergeron E Moore L Fournier K | 2009 | Arch Orthop Trauma Surg2009，129，11： | 1 |
| 5 | Electrophysiological recording of deep tendon reflexes:normative data in children and in adults显示文摘 | Pereon Y Nguyen The Tich S Fournier E | 2004 | Neurophysiol Clin2004，34，34： | 1 |
| 6 | Isolation of eight polymorphic microsatellite loci,using an enrichment protocol,in the phyto pathogenic fungus Fusarium culmorum显示文摘 | FOURNIER E VAUTRIN D | 2002 | Mol Ecol Notes2002，2，： | 1 |
| 7 | Value of microimmunofluorescence for diagnosis and follow-up of Bartonella endocardi tis 显示文摘 | Fournier P E Mainardi J L Raoult D | 2002 | Clin Diagn Lab Immunol2002，9，： | 1 |
| 8 | The epidemiology and control of Acinetobacter baumannii in health care facilities显示文摘 | Fournier P E Richet H | 2006 | Clin Infect Dis2006，42，5： | 1 |
| 9 | Proposed universal accelerated test for alkali-aggregate recation the concrete microbar test 显示文摘 | Grattan-Bellew P E Cybanski G Fournier B | 2014 | Cement Concrete and Aggregates2014，25，2： | 1 |
| 10 | The epidemiology and control of Acinetobacter baumannii in health care facilities 显示文摘 | FOURNIER P E IRICHET H | 2006 | Clin Infect Dis2006，42，5： | 1 |
| 11 | Relationship between storage and secretion of hepatic lipids in two breeds of geese with different susceptibility to liver steatosis显示文摘 | Fournier E Peresson R Guy G | 1997 | Poult Sci1997，76，4： | 1 |
| 12 | New mutations of SCN4A cause a potassium - sensitive normokalemie periodic paralysis 显示文摘 | Vicart S Sternberg D Fournier E | 2004 | Neurology2004，63，11： | 1 |
| 13 | Genesys - Pro: innovations in test program generation for functional processor verification 显示文摘 | Adir A Almoq E Fournier L | 2004 | Design & Test of Computers IEEE2004，21，2： | 1 |
| 14 | Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration 显示文摘 | Fournier A E GrandPre T Strittmatter S M | 2001 | Nature2001，409，6818： | 1 |
| 15 | Outcome and treatment of Bartonella endocarditis 显示文摘 | Raoult D Fournier P E Vandenesch F | 2003 | Arch Intern Med2003，163，： | 1 |
| 16 | Mapping aboveground tree biomass at the stand level from inventory information: test cases in Newfoundland and Quebec 显示文摘 | Fournier R A Luther J E Guindon L | 2003 | Canadian Journal of Forest Research2003，33，10： | 1 |
| 17 | Suicide PCR on skin specimens diagno-sis of rickett siosis for显示文摘 | FOURNIER P E RAOULT D | 2004 | J China Microbiol2004，42，： | 1 |
| 18 | Incorporation of a mixture of plant feedstuffas substi- tute for fish meal in diets of juvenile turbot ( Psetta maxima) 显示文摘 | FOURNIER V HUELVAN C DESBRUYERES E | 2004 | Aquaculture2004，236，1234： | 1 |
| 19 | New mutations of SCN4A cause a potassium-sensitive normokalemic periodic paralysis 显示文摘 | Vicart S Sternberg D Fournier E | 2004 | Neurology2004，63，11： | 1 |
| 20 | Partition of the Botrytis cinerea complex in France using multiple gene genealogies显示文摘 | FOURNIER E GIRAUD T ALBERTINI C | 2005 | Mycologia2005，97，6： | 1 |
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