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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse 显示文摘 | Combelles C M Albertini D F | 2003 | Biology of Reproduction2003，68，3： | 1 |
| 3 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse显示文摘 | COMBELLES C M ALBERTINI D F | 2003 | Biol Reprod2003，68，3： | 1 |
| 4 | Strain-rate effect on the tensile behavior of concrete at different relative humidity levels显示文摘 | Cadoni E Labibes K Albertini C | 2001 | Materials and Structures/ Materiaux et Constructions2001，34，235： | 1 |
| 5 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer 显示文摘 | Albertini J J Lyman GH Cox C | 1996 | JAMA1996，276，22： | 1 |
| 6 | Partition of the Botrytis cinerea complex in France using multiple gene genealogies显示文摘 | FOURNIER E GIRAUD T ALBERTINI C | 2005 | Mycologia2005，97，6： | 1 |
| 7 | Characterization and taste-masking evaluation of acetaminophen granules:comparison between different preparation methods in a high-shear mixer显示文摘 | Albertini B Cavallari C Passerini N | 2004 | Eur J Pharm Science2004，21，23： | 1 |
| 8 | Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy 显示文摘 | Teodori L Albertini M C Uguccioni F | 2006 | Cytometry A2006，69，2： | 1 |
| 9 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer 显示文摘 | Albertini JJ Lyman GH Cox C | 1996 | JAJA1996，276，22： | 1 |
| 10 | Study of the Mechanical Properties of Plain Concrete Under Dynamic Loading显示文摘 | Albertini C Cadoni E | 1999 | Experimental Mechanics1999，39，2： | 1 |
| 11 | Origins and manifestations of oocyte maturation competencies显示文摘 | Albertini D F Sanfins A Combelles C M | 2003 | Reprod Biomed Online2003，6，4： | 1 |
| 12 | Strain-rate effect on the tensile behavior of concrete at different relative humidity levels显示文摘 | Cadoni E Labibes K Albertini C | 2001 | Materials and Structures2001，34，： | 1 |
| 13 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer显示文摘 | Albertini JJ Lyman GH Cox C | 1996 | JAMA1996，276，22： | 1 |
| 14 | Changes in organic acids and sugars during early stages of development of acidic and acidless citrus fruit显示文摘 | Albertini MV Carcouet E Pailly O Gambotti C Luro F Berti L | 2006 | J Agric Food Chem2006，54，21： | 1 |
| 15 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer显示文摘 | Albertini J J Lyman GH Cox C | 1996 | JAMA1996，276，22： | 1 |
| 16 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer显示文摘 | Albertini JJ Lyman GH Cox C | 1996 | JAMA1996，276，22： | 1 |
| 17 | Evolution of quality of life,mental health,and coping strategies in amyotrophic lateral sclerosis:a pilot study显示文摘 | Montel S Albertini L Desnuelle C | 2012 | J Palliat Med2012，15，11： | 1 |
| 18 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer显示文摘 | Albertini JJ lyman GH COX C | 1996 | JAMA1996，276，： | 1 |
| 19 | Lymphatic mapping and sentinel node biopsy in the patients with breast cancer显示文摘 | Albertini J J Lyman G H Cox C | 1996 | JAMA1996，276，22： | 1 |
| 20 | Study of the mechanical properties of plain concrete under dynamic loading 显示文摘 | Albertini C Cadoni E | 1999 | Experimental Mechanics1999，39，2： | 1 |
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