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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Structure and expression of chicken metallothionein 显示文摘 | Fernando L P Wei D Y Andrews G K | 1989 | J Nutr1989，119，2： | 1 |
| 3 | The spectrum of acute renal failure in the intensive care unit compared with that seen in other settings显示文摘 | Eduardo J Julio P | 1998 | Kid Int1998，53，166： | 1 |
| 4 | The Selforganizing Map, the Geo-SOM, and Relevant Variants for Geosci- ences显示文摘 | Fernando B Victor L Marco P | 2005 | Computers : Geosciences2005，31，2： | 1 |
| 5 | Providing EAP-based Kerberos pre-authentication and advanced authorization for network federations显示文摘 | Rafael Mar í n-L ó pez Fernando Pere í guez Gabriel L ó pez Alejandro P é rez-M é ndez | | 0，，05： | 1 |
| 6 | Portable acoustic device for detection of coconut palms infested by Rynchophorus ferrugineus (Coleoptera:Curculionidae)显示文摘 | Siriwardena K A P Fernando L C P Nanayakkara N | | 0，，： | 1 |
| 7 | Invasive species can handle higher leaf temperature under water stress than Mediterranean natives显示文摘 | Oscar G Jose P L Fernando V | 2011 | Envi- ronmental and Experimental Botany2011，71，2： | 1 |
| 8 | Rearing of coconut mite Aceria guerreronis and the predatory mite Neoseiulus bara- ki in the laboratory 显示文摘 | De Silva P H Fernando L C | 2008 | Experimental and Applied Ac- arology2008，44，5： | 1 |
| 9 | Structural Analysis of Wind-Turbine Blades by a Generalized Timoshenko Beam Model 显示文摘 | Alejandro D O Fernando L P | 2010 | Journal of Solar Energy Engineering2010，132，： | 1 |
| 10 | Effect of incorpora- tion of peanut and sesame oils and their epoxides on the structure of polyvinyl chloride 显示文摘 | L karunanayake P N J Fernando | 2006 | J Natn Sci Founda- tion Sri Lanka2006，34，2： | 1 |
| 11 | Intracranial arterial dolichoectasia and small-vessel disease in stroke patients显示文摘 | Fernando P Julien L Pierre Jean T | 2005 | Ann Neurol2005，57，： | 1 |
| 12 | Quality analysis for 3D video using 2D video quality models 显示文摘 | Yasakethu S L P Hewage C T E R Fernando W A C | 2008 | IEEE Transactions on Consumer Electronics2008，54，4： | 1 |
| 13 | Principal components analysis applied to performance and carcass traits in the chicken显示文摘 | Luís Fernando Batista P Irineu Umberto P Cláudio Manoel Rodrigues D M M^onica Corrêa L Luiz Lehmann C | 2006 | Anim Res2006，55，： | 1 |
| 14 | Activation of the chicken metallothionein promoter by metals and oxidative stress in cultured cells and transgenic mice 显示文摘 | Dalton T Paria B C Fernando L P | 1997 | Comp Biochem Physiol B Biochem Mol Biol1997，116，： | 1 |
| 15 | Intracranial arterial dolichoeetasia and its relation with atheroselerosis and stroke subtype显示文摘 | Fernando P Julien L Pierre-Jean T | 2003 | Neurology2003，61，： | 1 |
| 16 | Structure and ex- pression of chicken metallothionein显示文摘 | Fernando L P Wei D Y Glen K A | 1989 | Nutriton1989，1109，2： | 1 |
| 17 | Investigation of the effects of salinity and dietary protein level on growth and survival of Pacific white shrimp, Litopenaeus vannamei 显示文摘 | Martin P V Mayra L G Fernando J B | 2007 | J World Aquac Soc2007，38，4： | 1 |
| 18 | Providing EAP-based Kerberos pre-authentication and advanced authorization for network federations显示文摘 | Rafael Marín-López Fernando Pere íguez Gabriel López Alejandro Pérez-Méndez | | 0，，5： | 1 |
| 19 | Thermal properties of uncross-linked and cross-linked LL- DPE/wax blends 显示文摘 | MARABELLA F M WESTPHAL S P FERNANDO P L | 2000 | Polym Degrad Stab2000，70，1： | 1 |
| 20 | Pre- dicting sensation of depth in 3D video显示文摘 | Yasakethu S L P De Silva D Fernando W A C | 2010 | Electronics let- ters2010，46，12： | 1 |
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