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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | Laparoscopic Approach to Colorectal Procedures in the Obese Patient: Risk Factor or Benefit?显示文摘 | Hubert Scheidbach Frank Benedix Omar Hügel Daniela Kose Ferdinand K?ckerling Hans Lippert | 2007 | Obesity Surgery2007，，1： | 1 |
| 3 | Edge and line feature extraction based on covaiance models 显示文摘 | FERDINAND V D H | 1995 | IEEE Transactions on Pattern Analysis Machine Intelligence1995，17，1： | 1 |
| 4 | Statin therapy accelerates reendothelialization:a novel effect involving mobilization and incorporation of bone marrowderived endothelial progenitor cells显示文摘 | Dirk HW Kilian R Ferdinand H | 2002 | Circulation2002，105，： | 1 |
| 5 | Computer aided tumor resection in the pelvis显示文摘 | Christian Krettek Jens Geerling Leonard Bastian Musa Citak Ferdinand Rücker Daniel Kendoff Tobias Hüfner | 2004 | Injury2004，，： | 1 |
| 6 | IKKαcontrols canonical TGFβ–SMAD signaling to regulate genes expressing SNAIL and SLUG during EMT in Panc1 cel s显示文摘 | Martina B Barbara S Ferdinand H | | 0，，24： | 1 |
| 7 | Efficient adaptive density estimation per image pixel for the task of background subtraction显示文摘 | ZIVOVIC Z FERDINAND H | | 0，，26： | 1 |
| 8 | Stimulation of endothelial progenitor cells:a new putative therapeutic effect of angiotensin Ⅱ receptor antagonists 显示文摘 | Ferdinand H Bahhnann Kirstende G | 2005 | Hypertension2005，45，： | 1 |
| 9 | EPP:renoprotection beyond anemia correction显示文摘 | Fliser D Ferdinand H Haller H | 2006 | Pediatr Nephrol2006，221，： | 1 |
| 10 | Recursive unsupervised learning of finite mixture models显示文摘 | Zoran Z van der Ferdinand H | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，5： | 1 |
| 11 | Fast and precise WCET pre- diction by separated cache and path analyses 显示文摘 | Theiling H Ferdinand C Wilhelm R | 2000 | Real-time Sys- tems2000，18，23： | 1 |
| 12 | EPO : renoproteetion be- yond anemia correction 显示文摘 | Fliser D Ferdinand H Hailer H et ai | 2006 | Pediatr Nephrol2006，21，： | 1 |
| 13 | Two common functional polymorphisms in the promoter region of the coagulation factor Ⅶ gene determining plasma factor Ⅶ activity and mass concent ration 显示文摘 | FERDINAND M VANT H ANGELA S | 1999 | Blood1999，93，10： | 1 |
| 14 | The metabolic fate of red wine and grape juice polyphenols in humans assessed by metabolomics显示文摘 | Van Dorsten Ferdinand A Glen Christian H Van Velzen Ewoud J J | 2009 | Molecular nutrition & food research2009，54，7： | 1 |
| 15 | Statin-induced improvement of endothelial progenitor cell mobilization,myocardial neovascularization,left ventricular function,and survival after experimental myocardial infarction requires endothelial citric oxide synthase显示文摘 | UlfLandmesser Niels E Ferdinand H | 2004 | Circulation2004，110，： | 1 |
| 16 | Fiscal competition over taxes and public inputs 显示文摘 | Sebastian H Ferdinand M Johannes Re | 2012 | Regional Science and Urban Economics2012，42，3： | 1 |
| 17 | Fast and precise WCET prediction by separated cache and path analysis 显示文摘 | Theiling H Ferdinand C Wilhelm R | 2000 | Real Time Systems2000，18，23： | 1 |
| 18 | 显示文摘 | FERDINAND C G CORALIE H R PAULETTE P | 2007 | J Am Chem Soc2007，129，13： | 1 |
| 19 | Efficient adaptive density estima-tion per image pixel for the task of background subtraction-Pattem Recognition Letters显示文摘 | Zivovic Z Ferdinand H | 2006 | 26(7)2006，，： | 1 |
| 20 | Statin therapy accelerates reendothelialization 显示文摘 | Dirk HW Kilian R Ferdinand H | 2002 | Circulation2002，105，： | 1 |
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