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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | Blocking the effects of interleukin-6 in rheumatoid Arthritis and other infammatory rheumatic diseases:systematic literature review and meta-analysis Informing a consensus statement显示文摘 | Monika MSchoels Desiree vander Heijde Ferdinand C Breedveld | 2013 | Ann Rheum Dis2013，72，： | 1 |
| 3 | Community-Based Approaches to Prevention and Management of Hypertension and Cardiovascular Disease显示文摘 | Ferdinand KC Patterson KP Taylor C | 2012 | Clinical Hypertension2012，14，33： | 1 |
| 4 | Genetic Diversity of Mycobacterium tuberculosis in sicily based on spoligotyping and variable number of tandem DNA repeats and comparison with a spoligotyping database for population-based analysis显示文摘 | Sola C Ferdinand S Mammina C | 2001 | Journal of Clinical Microbiology2001，39，： | 1 |
| 5 | Intensive insulin therapy in critically ill patients显示文摘 | van den Berghe G Wouters P Weekers F Verwaest C Bruyninckx F Schetz M Vlasselaers D Ferdinande P Lauwers P Bouillon R | 2001 | N Engl J Med2001，345，： | 1 |
| 6 | Peripheral and central blood pressure responses of combination aliskiren/hydrochlorothiazide and amlodipine monotherapy in African American patients with stage 2 hypertension: the ATLAAST trial显示文摘 | Keith C Ferdinand James Pool Richard Weitzman Das Purkayastha Raymond Townsend | 2011 | Journal of clinical hypertension (Greenwich Conn)2011，13，5： | 1 |
| 7 | Fast and precise WCET pre- diction by separated cache and path analyses 显示文摘 | Theiling H Ferdinand C Wilhelm R | 2000 | Real-time Sys- tems2000，18，23： | 1 |
| 8 | Genetic diversity of Mycobacterium tuberculosis in sicily based on spolygotyping and variable number of tandem DNA repeats and comparison with a spolygotyping database for population based analysis显示文摘 | Sola C Ferdinand S Savine E | 2001 | J Clin Microbiol2001，39，： | 1 |
| 9 | Optimizing intraoperative cerebral oxygen delivery using non-invasive cerebral oximetry decreases the incidence of stroke for cardiac surgical patients显示文摘 | Goldman S Sutter F Ferdinand F Trace C | 2004 | Heart Surg Forum2004，7，5： | 1 |
| 10 | Clinicopatho-logical significance of indoleamine 2,3-dioxygenase I ex-pression in colorectal cancer显示文摘 | Ferdinande L Decaestecker C Verset L | 2012 | Br J Cancer2012，106，2： | 1 |
| 11 | Intensive insulin therapy in the critically ill patients显示文摘 | van den Berghe G Wouters P Weekers F Verwaest C Bruyninckx F Schetz M Vlasselaers D Ferdinande P Lauwers P Bouillon R | 2001 | N Engl J Med2001，345，8： | 1 |
| 12 | Community-Based Approaches to Prevention and Management of Hypertension and Cardiovascular Disease显示文摘 | Ferdinand K C Patterson K P Taylor C | 2012 | The Journal of Clinical Hypertension2012，14，5： | 1 |
| 13 | Fast and precise WCET prediction by separated cache and path analysis 显示文摘 | Theiling H Ferdinand C Wilhelm R | 2000 | Real Time Systems2000，18，23： | 1 |
| 14 | 显示文摘 | FERDINAND C G CORALIE H R PAULETTE P | 2007 | J Am Chem Soc2007，129，13： | 1 |
| 15 | Blocking the effects of interleukin -6 in rheumatoid arthritis and other inflammatory rheumatic disease: systematic literature review and mete-analysis informing a consensus statement显示文摘 | Monika M Schoels Desiree van der Heijde Ferdinand C Breedveld | 2013 | Ann Rheun Dis2013，，： | 1 |
| 16 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs显示文摘 | Josef S Smolen Robert Landewe Ferdinand C Breedveld | 2010 | Ann Rheum Dis2010，69，5： | 1 |
| 17 | Community-based approaches to prevention and management of hypertension and cardiovascular disease显示文摘 | Ferdinand KC Patterson KP Taylor C | 2012 | J Clin Hypertens (Greenwich)2012，14，5： | 1 |
| 18 | Mechanism of charge migration through DNA: Molecular wire behavior, single-step tunneling or hopping 显示文摘 | Ferdinand C Grozema Yuri A Berlin | 2000 | J Am Chem Soc2000，122，10： | 1 |
| 19 | Realities of newer beta-blockers for the management of hypertension显示文摘 | Manrique C Giles TD Ferdinand KC | 2009 | J Clin Hypertens (Greenwich)2009，11，7： | 1 |
| 20 | The glass temperature of linear polyethylene 显示文摘 | Ferdinand C Stehling Leo Mandelkern | 1970 | M aeromolecules1970，3，2： | 1 |
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