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| 1 | Comparison between the SAPIEN S3 and the SAPIEN XT transcatheter heart valves:A single-center experience显示文摘AIM To investigate the clinical outcomes of transcatheter aortic valve implantation(TAVI) with the SAPIEN 3 transcatheter heart valve(S3-THV) vs the SAPIEN XT valve(XT-THV).METHODS We retrospectively analyzed 507 patients that underwent TAVI with the XT-THV and 283 patients that received the S3-THV at our institution between March 2010 and December 2015.RESULTS Thirty-day mortality(3.5% vs 8.7%:OR=0.44,P=0.21) and 1-year mortality(25.7% vs 20.1%,P=0.55) were similar in the S3-THV and the XT-THV groups.The rates of both major vascular complication and paravalvular regurgitation(PVR)>1 were almost 4 times lower in the S3-THV group than the XT-THV group(major vascular complication: 2.8% vs 9.9%,P<0.0001:PVR>1: 2.4% vs 9.7%,P<0.0001).However,the rate of new pacemaker implantation was almost twice as high in the S3-THV group(17.3% vs 9.8%,P=0.03).In the S3 group,independent predictors of new permanent pacemaker were pre-procedural RBBB(OR=4.9:P=0.001),pre-procedural PR duration(OR=1.14,P=0.05) and device lack of coaxiality(OR=1.13:P=0.05) during deployment.CONCLUSION The S3-THV is associated to lower rates of major vascular complications and PVR but higher rates of new pacemaker compared to the XT-THV.Sub-optimal visualization of the S3-THV in relation to the aortic valvular complex during deployment is a predictor of new permanent pacemaker. | Fadi J Sawaya Marco Spaziano Thierry Lefèvre Andrew Roy Phillippe Garot Thomas Hovasse Antoinette Neylon Hakim Benamer Mauro Romano Thierry Unterseeh Marie-Claude Morice Bernard Chevalier | 2016 | World Journal of Cardiology2016，8，12： | 2 |
| 2 | Biobleaching chemistry of laccase-mediator systems on high-lignin-eontent kraft pulps 显示文摘 | Fadi S C Arthur J R | 2004 | Canadian Journal of Chemistry2004，82，2： | 1 |
| 3 | Prevalence of Peripheral Blood Cytopenias (Hypersplenism)in Patients With Nonalcoholic Liver Disease显示文摘 | Fadi NB J Carlos T Kevin D | 2000 | Am Coll of Gastroeterology2000，95，10： | 1 |
| 4 | A comparison of the quantitative methods for the analysis of the platinum-containing anticancer drug cis--plat-inum(II) (ZD0473) by HPLC coupled to either a triple quadrupole mass spectrometer or an inductively coupled plasma mass spectrometer显示文摘 | CHRISTOPHER J S LAN D W FADI A S | 2003 | Anal Chem2003，75，2： | 1 |
| 5 | Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A2 receptor显示文摘 | Harold J TING Wallace J MURRAY Fadi T KHASAWNEH | 2010 | Acta Pharmacologica Sinica2010，31，2： | 1 |
| 6 | CEO Turnover and Relative Performance Evaluation显示文摘 | Dirk J K Fadi | 2014 | Journal of Finance2014，，： | 1 |
| 7 | The current state of patient safety culture in Lebanese hospitals: a study at baseline 显示文摘 | Fadi J Maha J Hani D | 2010 | International Journal for Quality in Health Care2010，22，5： | 1 |
| 8 | Predictors and outcomes of patient safety culture in hospitals 显示文摘 | Fadi J Hani D Diana J | 2011 | Health Services Research2011，11，45： | 1 |
| 9 | A multi-granularity power modeling methodology for embedded processors显示文摘 | PARK Y H SUDEEP P FADI J K | 2011 | IEEE Transactions on Very Large Scale Integration (VLSI) Systems2011，19，4： | 1 |
| 10 | Prevalence of Peripheral Blood Cytopenias (Hypersplenism)in Patients With Nonalcoholic Liver Disease显示文摘 | Fadi NB J Carlos T Kevin D | 2000 | Am Coil of Gastroeterology2000，95，10： | 1 |
| 11 | RT–PCR analysis of Candida albicans ALS gene expression in a hyposalivatory rat model of oral candidiasis and in HIV-positive human patients显示文摘 | Clayton B Green Sandra Manfra Marretta Georgina Cheng Fady F Faddoul E. J Ehrhart Lois L Hoyer | 2006 | Medical Mycology2006，，2： | 1 |
| 12 | Predictors and outcomes of patient safe- ty culture in hospitals显示文摘 | Fadi EJ Hani D Diana J | 2011 | BMC Heal Servi Res2011，11，2： | 1 |
| 13 | Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study显示文摘 | Khaled M Musallam Hani M Tamim Toby Richards Donat R Spahn Frits R Rosendaal Aida Habbal Mohammad Khreiss Fadi S Dahdaleh Kaivan Khavandi Pierre M Sfeir Assaad Soweid Jamal J Hoballah Ali T Taher Faek R Jamali | 2011 | The Lancet2011，，9800： | 1 |
| 14 | A framework for reconfigurable computing:Task scheduling and context management显示文摘 | Rafael M Fadi J K Milagros F | 2001 | IEEE Trans on VLSI Systems2001，9，6： | 1 |
| 15 | A 10 Ms/s 10-Bit Successive approximation register analog to digital converter显示文摘 | Larivee Brian J Chie Wei Yew Gebara Fadi H | 2002 | EECS2002，598，11： | 1 |
| 16 | C - Reactive protein gene polymorphisms, C - Reactive protein blood levels, and cardio- vascular disease risk 显示文摘 | Fadi G Hage Alexander J | 2007 | AM Coil Cardiol2007，50，： | 1 |
| 17 | Modulation of plasma lipid levels and cholesterol kinetics b) phytosterol versus phytostanol esters 显示文摘 | Peter J Jones Mahmoud Raeini- Sarjaz Fady Y Ntanios | 2000 | Journal of Lipid Research2000，41，： | 1 |
| 18 | LIV-4:A novel model for predicting transplant-free survival in critically ill cirrhotics显示文摘BACKGROUND Critically ill patients with cirrhosis,particularly those with acute decompensation,have higher mortality rates in the intensive care unit(ICU)than patients without chronic liver disease.Prognostication of short-term mortality is important in order to identify patients at highest risk of death.None of the currently available prognostic models have been widely accepted for use in cirrhotic patients in the ICU,perhaps due to complexity of calculation,or lack of universal variables readily available for these patients.We believe a survival model meeting these requirements can be developed,to guide therapeutic decision-making and contribute to cost-effective healthcare resource utilization.AIM To identify markers that best identify likelihood of survival and to determine the performance of existing survival models.METHODS Consecutive cirrhotic patients admitted to a United States quaternary care center ICU between 2008-2014 were included and comprised the training cohort.Demographic data and clinical laboratory test collected on admission to ICU were analyzed.Area under the curve receiver operator characteristics(AUROC)analysis was performed to assess the value of various scores in predicting inhospital mortality.A new predictive model,the LIV-4 score,was developed using logistic regression analysis and validated in a cohort of patients admitted to the same institution between 2015-2017.RESULTS Of 436 patients,119(27.3%)died in the hospital.In multivariate analysis,a combination of the natural logarithm of the bilirubin,prothrombin time,white blood cell count,and mean arterial pressure was found to most accurately predict in-hospital mortality.Derived from the regression coefficients of the independent variables,a novel model to predict inpatient mortality was developed(the LIV-4 score)and performed with an AUROC of 0.86,compared to the Model for End-Stage Liver Disease,Chronic Liver Failure-Sequential Organ Failure Assessment,and Royal Free Hospital Score,which performed with AUROCs of 0.81,0.80,and 0.77,respectively.Patients in the internal validation cohort were substantially sicker,as evidenced by higher Model for End-Stage Liver Disease,Model for End-Stage Liver Disease-Sodium,Acute Physiology and Chronic Health Evaluation III,SOFA and LIV-4 scores.Despite these differences,the LIV-4 score remained significantly higher in subjects who expired during the hospital stay and exhibited good prognostic values in the validation cohort with an AUROC of 0.80.CONCLUSION LIV-4,a validated model for predicting mortality in cirrhotic patients on admission to the ICU,performs better than alternative liver and ICU-specific survival scores. | Christina C Lindenmeyer Gianina Flocco Vedha Sanghi Rocio Lopez Ahyoung J Kim Fadi Niyazi Neal A Mehta Aanchal Kapoor William D Carey Eduardo Mireles-Cabodevila Carlos Romero-Marrero | 2020 | World Journal of Hepatology2020，12，6： | 0 |
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