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| 1 | Identifying Important Predictors for Anastomotic Leak After Colon and Rectal Resection: Prospective Study on 616 Patients显示文摘 | Koianka Trencheva Kevin P. Morrissey Martin Wells Carol A. Mancuso Sang W. Lee Toyooki Sonoda Fabrizio Michelassi Mary E. Charlson Jeffrey W. Milsom | 2013 | Annals of Surgery2013，，1： | 2 |
| 2 | The Role of Extended Lymphadenectomy for Adenocarcinoma of the Head of the Pancreas: Strength of the Evidence显示文摘 | Michael B. Farnell Gerard V. Aranha Yuji Nimura Fabrizio Michelassi | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 2 |
| 3 | Adenosquamous-cell carcinoma in ulcerative colitis显示文摘 | Dr. Fabrizio Michelassi M.D. Anthony G. Montag M.D. George E. Block M.D | 1988 | Diseases of the Colon & Rectum1988，，4： | 1 |
| 4 | Squamous-cell carcinoma of the colon显示文摘 | Dr. Fabrizio Michelassi M.D. Lawrence A. Mishlove Francesco Stipa George E. Block M.D | 1988 | Diseases of the Colon & Rectum1988，，3： | 1 |
| 5 | Laparoscopic Restorative Proctocolectomy with Ileal Pouch Anal Anastomosis: A Comparative Observational Study on Long-term Functional Results显示文摘 | Alessandro Fichera Mark T. Silvestri Roger D. Hurst Michele A. Rubin Fabrizio Michelassi | 2009 | Journal of Gastrointestinal Surgery2009，，： | 1 |
| 6 | Adenosquamous-cell carcinoma in ulcerative colitis显示文摘 | Dr. Fabrizio Michelassi M.D. Anthony G. Montag M.D. George E. Block M.D | 1988 | Diseases of the Colon & Rectum1988，，4： | 1 |
| 7 | The Role of Extended Lymphadenectomy for Adenocarcinoma of the Head of the Pancreas: Strength of the Evidence显示文摘 | Michael B. Farnell Gerard V. Aranha Yuji Nimura Fabrizio Michelassi | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 1 |
| 8 | The Role of Extended Lymphadenectomy for Adenocarcinoma of the Head of the Pancreas: Strength of the Evidence显示文摘 | Michael B. Farnell Gerard V. Aranha Yuji Nimura Fabrizio Michelassi | 2008 | Journal of Gastrointestinal Surgery2008，，4： | 1 |
| 9 | Alvimopan, a Novel, Peripherally Acting μ Opioid Antagonist: Results of a Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial of Major Abdominal Surgery and Postoperative Ileus显示文摘 | Bruce G. Wolff Fabrizio Michelassi Todd M. Gerkin Lee Techner Kathie Gabriel Wei Du Bruce A. Wallin | 2004 | Annals of Surgery2004，，4： | 1 |
| 10 | A targetable pathway to eliminate TRA-1-60^(+)/TRA-1-81^(+)chemoresistant cancer cells显示文摘Chemoresistance is a primary cause of treatment failure in pancreatic cancer.Identifying cell surface markers specifically expressed in chemoresistant cancer cells(CCCs)could facilitate targeted therapies to overcome chemoresistance.We performed an antibody-based screen and found that TRA-1-60 and TRA-1-81,two‘stemness’cell surface markers,are highly enriched in CCCs.Further-more,TRA-1-60^(+)/TRA-1-81^(+)cells are chemoresistant compared to TRA-1-60^(-)/TRA-1-81^(-)cells.Transcriptome profiling identified UGT1A10,shown to be both necessary and sufficient to maintain TRA-1-60/TRA-1-81 expression and chemoresistance.From a high-content chemical screen,we identified Cymarin,which downregulates UGT1A10,eliminates TRA-1-60/TRA-1-81 expression,and increases chemosensitivity both in vitro and in vivo.Finally,TRA-1-60/TRA-1-81 expression is highly specific in primary cancer tissue and positively correlated with chemoresistance and short survival,which highlights their potentiality for targeted therapy.Therefore,we discovered a novel CCC surface marker regulated by a pathway that promotes chemoresistance,as well as a leading drug candidate to target this pathway. | Lei Tan Xiaohua Duan Pratyusha Mutyala Ting Zhou Sadaf Amin Tuo Zhang Brian Herbst Gokce Askan Tomer Itkin Zhaoying Xiang Fabrizio Michelassi Michael D.Lieberman Christine AIacobuzio-Donahue Steven DLeach Todd Evans Shuibing Chen | 2023 | Journal of Molecular Cell Biology2023，15，6： | 0 |
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