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| 1 | challenges of advanced hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is an aggressive malignancy,resulting as the third cause of death by cancer each year. The management of patients with HCC is complex,as both the tumour stage and any underlying liver disease must be considered conjointly. Although surveillance by imaging,clinical and biochemical parameters is routinely performed,a lot of patients suffering from cirrhosis have an advanced stage HCC at the first diagnosis. Advanced stage HCC includes heterogeneous groups of patients with different clinical condition and radiological features and sorafenib is the only approved treatment according to Barcelona Clinic Liver Cancer. Since the introduction of sorafenib in clinical practice,several phase Ⅲ clinical trials have failed to demonstrate any superiority over sorafenib in the frontline setting. Locoregional therapies have also been tested as first line treatment,but their role in advanced HCC is still matter of debate. No single agent or combination therapies have been shown to impact outcomes after sorafenib failure. Therefore this review will focus on the range of experimental therapeutics for patients with advanced HCC and highlights the successes and failures of these treatments as well as areas for future development. Specifics such as dose limiting toxicity and safety profile in patients with liver dysfunction related to the underlying chronic liver disease should be considered when developing therapies in HCC. Finally,robust validated and reproducible surrogate end-points as well as predictive biomarkers should be defined in future randomized trials. | Stefano Colagrande Andrea L Inghilesi Sami Aburas Gian G Taliani Cosimo Nardi Fabio Marra | 2016 | World Journal of Gastroenterology2016，22，34： | 19 |
| 2 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 3 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 4 | Papillary fistulotomy vs conventional cannulation for endoscopic biliary access:A prospective randomized trial显示文摘AIM To compare the cannulation success, biochemical profile, and complications of the papillary fistulotomy technique vs catheter and guidewire standard access.METHODS From July 2010 to May 2017, patients were prospectively randomized into two groups: Cannulation with a catheter and guidewire(Group Ⅰ) and papillary fistulotomy(Group Ⅱ). Amylase, lipase and C-reactive protein at T0, as well as 12 h and 24 h after endoscopic retrograde cholangiopancreatography, and complications(pancreatitis, bleeding, perforation) were recorded.RESULTS We included 102 patients(66 females and 36 males, mean age 59.11 ± 18.7 years). Group Ⅰ and Group Ⅱ had 51 patients each. The successful cannulation rates were 76.5% and 100%, respectively(P = 0.0002). Twelve patients(23.5%) in Group Ⅰ had a difficult cannulation and underwent fistulotomy, which led to successful secondary biliary access(Failure Group). The complication rate was 13.7%(2 perforations and 5 mild pancreatitis) vs 2.0%(1 patient with perforation and pancreatitis) in Groups Ⅰ and Ⅱ, respectively(P = 0.0597). CONCLUSION Papillary fistulotomy was more effective than guidewire cannulation, and it was associated with a lower profile of amylase and lipase. Complications were similar in both groups. | Carlos Kiyoshi Furuya Paulo Sakai Fabio Ramalho Tavares Marinho Jose Pinhata Otoch Spencer Cheng Lívia Lemes Prudencio Eduardo Guimaraes Hourneaux de Moura Everson Luiz de Almeida Artifon | 2018 | World Journal of Gastroenterology2018，24，16： | 2 |
| 5 | Resection of Nonresectable Liver Metastases from Colorectal Cancer After Neoadjuvant Chemotherapy显示文摘 | Henry Bismuth René Adam Fran?is Lévi Christian Farabos Fabio Waechter Denis Castaing Pietro Majno Luc Engerran | 1996 | Annals of Surgery1996，，4： | 2 |
| 6 | Class I infrared eye blinking detector显示文摘 | FABIO L C | 2008 | Sensors and Actuators A:Physical2008，148，2： | 1 |
| 7 | Consequences of sleep deprivation on neurotransmitter receptor expression and function 显示文摘 | Fabio L Caroline K Anita L | 2009 | Europ J Neutos2009，29，9： | 1 |
| 8 | Feasibility of an electronic nose to differentiate commercial Spanish wines elaborated from the same grape variety显示文摘 | María de las Nieves López de Lerma Andrea Bellincontro Teresa García-Martínez Fabio Mencarelli Juan José Moreno | 2013 | Food Research International2013，，2： | 1 |
| 9 | Inflammation and adipose tissue: effects of progressive load training in rats显示文摘 | Fabio S L | 2010 | Li pids in Health andDisease2010，9，： | 1 |
| 10 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 11 | A fractal-based algorithm for detecting first arrivals on seismic traces显示文摘 | Mike D D Ron D L | 1993 | Geophysics1993，61，4： | 1 |
| 12 | Conservation treatment by chemotherapy and uterine arteries embolization of a cesarean scar pregnancy显示文摘 | Fabio G Domenico L Massimo F | 2002 | Eur J Obstet Gynecol Reprod Biol2002，103，2： | 1 |
| 13 | Innovation networks:From technological development to business model reconfiguration显示文摘 | Rogerio C Fabio M G Gilnei L M | 2007 | Technovation2007，27，8： | 1 |
| 14 | Productivity, innovation and R&D:Micro evidence for Italy显示文摘 | MARIA L P FABIO S ALESSANDRO S | 2006 | Europe- an Economic Review2006，，50： | 1 |
| 15 | Hemodynamic effects of intravenous morphine infusion in ventilated preterm babies显示文摘 | Sabatino G Quartulli L Di Fabio S | 1997 | Early Hum Dev1997，47，3： | 1 |
| 16 | Appraisal of the role of angiotensin Ⅱ and aldosterone in ventricular myocyte apoptosis in adult normotensive rat显示文摘 | Noeleen DA Fabio F Roberto L | 2002 | J Mol Cell Cardiol2002，34，： | 1 |
| 17 | Endometrial stromal sarcoma: analysis of treatment failures and survival显示文摘 | Enrico S Fabio L | 1996 | Gynecol Oncol1996，63，： | 1 |
| 18 | Stress Echocardiography and the Human Factor: The Impor- tance of Being Expert显示文摘 | Eugenio P Fabio L Andres O | 1991 | J Am Coil Cardiol1991，17，： | 1 |
| 19 | Conservation treatment by chemotherapy and uterine arteries embolization of a cesarean scar preg- nancy显示文摘 | Fabio G Domenico L Massimo F | 2002 | Eur J Obstet Gynecol Reprod Biol2002，103，： | 1 |
| 20 | Inhibition of anchorage dependent cell spreading triggers apoptosis in cultured human edothelial cell显示文摘 | Fabio R Zanetti A Sironi M Polentarutti N Lanfrancone L Dejana E | 1994 | Cell Biol1994，127，3： | 1 |
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