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| 1 | Numerical Research on Inlet Total Pressure Distortion in a Transonic Compressor with Non-Axisymmetric Stator Clearance显示文摘Inlet total pressure distortion has great adverse effects on the aero-engine performance. The distorted flow passes through the compressor and becomes non-uniform in the downstream blade rows. Different from previous studies based on the assumption of circumferential uniformity, this study aims to improve circumferential non-uniform flow with the non-axisymmetric structure. Non-axisymmetric stator clearance was adopted to resolve the effects of non-uniform flow caused by inlet total pressure distortion in this paper. The 9 stators with tip clearance were installed in the distorted region and the flow field structure and performance under different operating conditions was studied. The study finds that the non-axisymmetric compressor with 9 tip clearance stators can ensure compressor efficiency while improving compressor stability margin. What’s more, the separation range and strength in the distorted region can be reduced significantly and the anti-distortion capability of compressor can be enhanced. | XU Wenfeng SUN Peng YANG Guogang HUANG Longsheng FU Wenguang | 2020 | Journal of Thermal Science2020，29，4： | 3 |
| 2 | Aerodynamic Characteristic Research on Final Stage Stator of a Highly Loaded Fan显示文摘Due to corner separation and other complex three-dimensional flows existing in the highly loaded stator, which influences the fan performance significantly, highly loaded stator blades of a transonic fan with a maximum camber angle of 57° were studied in this paper and sector cascade experiment was adopted. In order to get the stator aerodynamic parameters as realistic as possible and conduct the experiment without the existence of rotor, an adjustable guide vane was designed to simulate the velocity magnitude and direction of the stator inlet flow. Results show that the adjustable guide vane can simulate the rotor outlet velocity direction and magnitude in most span range. The deviation angle is positive and the maximum value is nearly 21° because the severe separation is at 27% span. Corner separation exists on both pressure side and suction side and the location of separation initiation is determined. Finally, the stator blades were redesigned with some suction slots on the suction side. Experiment results show that the suction slots change the flow field structure, increase the capability of flow turning, and decrease the flow loss. | FU Wenguang SUN Peng ZHONG Jingjun PAN Ruochi LI Lili YANG Muxiao | 2018 | Journal of Thermal Science2018，27，6： | 1 |
| 3 | 抗瘤中药制剂对结直肠癌T及NK细胞免疫抑制的体外逆转作用(英文)显示文摘Objective: Reversing effects of traditional Chinese medicines on colorectal tumor immunosuppressions of natural killer (NK) cell and T lymphocyte were analyzed to provide evidence on selecting medicines for patients according to the different types of tumor immunosuppression. Methods: Six traditional Chinese medicines, including Arsenious acid (AS), Ligustra-zine hydrochloride (LHC), Astragalus mongholicus bge (AMB), Matrine N-oxide (MOX), Polyporus umbellatus polysaccharide (PUPS) and Artesunate (ART), were enrolled. The reversing effects on suppression of murine splenocyte transformation and NK killing activity were measured by 3-{4,5-dimethyl-2-thiazolyl}-2,5-diphenyl tetrazolium (MTT), and the effects on the suppressed expression of interleukin 2 receptor α (IL-2Rα), CD3ε + ζ + and CD3ε - ζ + were detected by flow cytometry (FCM). The effects on immunosuppressive molecules were measured by enzyme linked immunosorbent assay (ELISA), including transforming growth factor β1 (TGF-β 1), vascular endothelial growth factor (VEGF), interleukin 4 (IL-4), IL-6, IL-10 and pros-taglandin (PG) E 2 . Results: (1) The reversing effects of AMB on the inhibition of NK killing and CD3ε + ζ + expression were the most significant; the effect of LHC on inhibition of CD3ε - ζ + expression was the strongest; the effects of AMB, PUPS and ART on inhibition of transformation were the greatest; and the effect of ART on inhibition of IL-2Rα expression was the strongest. (2) The correlated molecules of these medicines that exerted reversing effects on colorectal tumor immunosuppression were TGF-β 1 and IL-10. AMB had the highest down-regulating effect on the secretion of TGF-β 1 . AS and ART had the highest effects on IL-10. Conclusion: Reversing tumor immunosuppression through the down-regulation of immunosuppressive molecules is one of the novel antitumor mechanisms of traditional Chinese medicines. The clinical use of compounded prescriptions of ART combined with AMB and LHC should be considered to avoid the reduced treatment efficiency caused by tumor immunosuppression. | Cheng Cui Aixia Zhang Jianjun Hu Wenguang Zheng Zhanjiang Fu Lirong Oi Meixiang LiWei Lv | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，12： | 1 |
| 4 | Zyxin promotes hepatocellular carcinoma progression via the activation of AKT/mTOR signaling pathway显示文摘Hepatocellular carcinoma(HCC)is a common malignancy that is driven by multiple genes and pathways.The aim of this study was to investigate the role and specific mechanism of the actin-interacting protein zyxin(ZYX)in HCC.We found that the expression of ZYX was significantly higher in HCC tissues compared to that in normal liver tissues.In addition,overexpression of ZYX in hepatoma cell lines(PLC/PRF/5,HCCLM3)enhanced their proliferation,migration and invasion,whereas ZYX knockdown had the opposite effects(SK HEP-1,Huh-7).Furthermore,the change in the expression levels of ZYX also altered that of proteins related to cell cycle,migration and invasion.Similar results were obtained with xenograft models.The AKT/mTOR signaling pathway is one of the key mediators of cancer development.While ZYX overexpression upregulated the levels of phosphorylated AKT/mTOR proteins,its knockdown had the opposite effect.In addition,the AKT inhibitor MK2206 neutralized the pro-oncogenic effects of ZYX on the HCC cells,whereas the AKT activator SC79 restored the proliferation,migration and invasion of HCC cells with ZYX knockdown.Taken together,ZYX promotes the malignant progression of HCC by activating AKT/mTOR signaling pathway,and is a potential therapeutic target in HCC. | TIANYING CAI JUNJIE BAI PENG TAN ZHIWEI HUANG CHEN LIU ZIMING WU YONGLANG CHENG TONGXI LI YIFAN CHEN JIAN RUAN LIN GAO YICHAO DU WENGUANG FU | 2023 | Oncology Research2023，31，5： | 0 |
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