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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Frontal white matter vol-ume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease 显示文摘 | Babiloni C Frisoni G Steriade M | 2006 | Clin Neurophysiol2006，117，5： | 1 |
| 4 | Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry 显示文摘 | FRISONI G B TESTA C ZORZAN A | 2002 | Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 5 | Insulin resistance in cognitive impairment:the InCHIANTI study显示文摘 | Geroldi C Frisoni GB Paolisso G | 2005 | Arch Neurol2005，62，7： | 1 |
| 6 | Linear measures of atrophy in mild Alzheimers disease显示文摘 | Frisoni GB Beltramello A Weiss C | 1996 | AJNR1996，17，4： | 1 |
| 7 | Qualitative Estimates of Medical Temporal Atrophy as a Predictor of Progression From Mild Cognitive Im- pairment to Dementia 显示文摘 | Decarli C Frisoni GB Clark CM | 2007 | Arch NeuroI2007，64，： | 1 |
| 8 | Radial width of the temporal horn:a sensitive measure in Alzheimer disease显示文摘 | Geroldi C Beltramello A | 2002 | AJNR Am J Neuroradiol2002，23，1： | 1 |
| 9 | Editorial: Reflux, dyspepsia, and Rome Ⅲ ( or Rome IV ? ) 显示文摘 | STANGHELLINI V FRISONI C | 2010 | Am J Gastroenterol2010，105，12： | 1 |
| 10 | Gene does of the E4 Allele of apolipoprotein E and disease progression in sporadic late-onset Alzheimer's disease显示文摘 | Frisoni GB Govoni S Geroldi C | 1995 | Ann Neurol1995，37，5： | 1 |
| 11 | Cortical sources of resting EEG rhythms in mild cognitive impairment and subjective memory complaint显示文摘 | Babiloni C Visser P J Frisoni G | 2010 | Neurobiol Aging2010，31，： | 1 |
| 12 | White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment显示文摘 | Babiloni C Frisoni G B Pievani M | 2008 | Neuropsychologia2008，46，： | 1 |
| 13 | Hippocampal atrophy and EEG markers in subjects with mild cognitive impairment显示文摘 | Moretti DV Miniussi C Frisoni GB | 2007 | Clin Neurophysiol2007，118，12： | 1 |
| 14 | Radial width of temporal horn:a Sensitive measure in Mzheimer disease显示文摘 | Frisoni GB Geroldi C Behramello A | 2002 | Am J Neuroradiol2002，23，： | 1 |
| 15 | Alloprosthetic composite is a suitable reconstruction after periacetabular tumor resection 显示文摘 | Donati D Di Bella C Frisoni T | 2011 | Clin Orthop Relat Res2011，469，5： | 1 |
| 16 | Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia显示文摘 | DeCarli C Frisoni GB Clark CM | 2007 | Arch Neurol2007，64，1： | 1 |
| 17 | Detection of gray matter loss in mild Alzheimer's disease with voxel based morphometry显示文摘 | Frisoni GB Testa C Zorzan A | 2002 | J Neurol Neurosurg Psychiatry2002，73，： | 1 |
| 18 | Insulin resistance in cognitive impairment: the InCHIANTI study显示文摘 | Geroldi C Frisoni GB Paolisso G | 2005 | Arch Neurol2005，62，7： | 1 |
| 19 | Radial width ofthe temporal horn: a sensitive measurein Alzheimer disease显示文摘 | Frisoni GB Geroldi C Beltramello A | 2002 | AJNR Am J Neuroradiol2002，23，1： | 1 |
| 20 | Linear measures of atrophy in mild Alzheimer disease显示文摘 | Frisoni GB Beltramello A Weiss C | 1996 | AJNR1996，17，： | 1 |
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