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22篇 您的检索式：作者名="FRINGS C"

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	题名	作者	年代	出处	被引量
1	VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab显示文摘AIM:To gain mechanistic insights into the role played by epidermal growth factor receptor (EGFR) in the regulation of vascular endothelial growth factors (VEGFs) in colorectal cancer (CRC). METHODS:The impact of high-level expression of the growth factor receptors EGFR and VEGF receptor (VEGFR)3 and the VEGFR3 ligands VEGF-C and VEGF-D on disease progression and prognosis in human CRC was investigated in 108 patients using immunohistochemistry. Furthermore, the expression of the lymphangiogenic factors in response to the modulation of EGFR signalling by the EGFR-targeted monoclonal antibody cetuximab was investigated at the mRNA and protein level in human SW480 and SW620 CRC cell lines and a mouse xenograft model. RESULTS: Human CRC specimens and cell lines displayed EGFR, VEGF-C and VEGF-D expression with varying intensities. VEGF-C expression was associated with histological grade. Strong expression of VEGF-D was significantly associated with lymph node metastases and linked to a trend for decreased survival in lymph node-positive patients. EGFR blockade with cetuximab resulted in a significant decrease of VEGF-D expression in vitro and in vivo. CONCLUSION:In conclusion, the expression of VEGF-D in colorectal tumours is significantly associated with lymphatic involvement in CRC patients and such expression might be blocked effectively by cetuximab.	Markus Moehler Christian Frings Annett Mueller Ines Gockel Carl C Schimanski Stefan Biesterfeld Institute of Pathology Johannes Gutenberg University Mainz 55101 Germany Peter R Galle Martin H Holtmann	2008	World Journal of Gastroenterology2008，14，26：	15
2	Improved determination of total serum lipids by the sulfo -phospho - vanillin reaction 显示文摘	FRINGS C S FENDLEY T W DUNN R T	1972	Clin Chem1972，18，7：	1
3	Organic-Inorganic Hybrid Coatings for Coil Coating Application Based on Polyesters and Tetraethoxysilane显示文摘	FRINGS S MEINEMA H A VAN NOSTRUM C F	1998	Progress in Organic Coatings1998，33，4：	1
4	Improved determination of total serum lipids by the sulfo-phosphovanillin reaction显示文摘	Frings C S Fendley T W Dunn R T	1972	Clinical Chemistry1972，18，7：	1
5	Enantioselective nitrene transfer to sulfides catalyzed by a chiral iron complex显示文摘	Wang J Frings M Bolm C	2013	Angew Chem Int Ed2013，52，33：	1
6	Inflammatory markers in exhaled breath condensate following lung resection for bronchial carcinoma显示文摘	Jungraithmayr W Frings C Zissel G	2008	Respirology2008，13，7：	1
7	Ring Closing Enyne Metathesis: A Powerful Tool for the Synthesis of Heterocycles 显示文摘	Villar H M Frings Bolm C	2007	Chem Soc Rev2007，36，：	1
8	Morphology of hybrid coatings based on polyester,melamine resin,and silica and the relation with hardness and scratch resistance显示文摘	FRINGS S VAN NOSTRUM C F VAN DER LINDE R	2000	J Coat Tech2000，72，901：	1
9	Immunotoxicity testing in nonhuman primates 显示文摘	Grote-Wessels S Frings W Smith C A	2010	Methods Mol Biol2010，598，：	1
10	Organicinorganic hybrid coatings for coil coating application based on polyesters and trtraethoxysilane显示文摘	S Frings H A Meinema C F van Nostrum	1998	Progress in Organic Coating1998，33，：	1
11	Organic-inorganic hybrid coatings for coil coating application based on polyesters and tetraethoxysilane显示文摘	Frings S Meinema H A van Nostrum C F	1998	Progress in Organic Coatings1998，33，：	1
12	Organic-inorganic hybrid coatings for coil coating application based on polyesters and tetraethoxysilane 显示文摘	Frings S Meinema H A Van Nostrum C F	1998	Progress in Organic Coatings1998，33，2：	1
13	Expression of aberrantly glycosylated mucin-1 in ovarian cancer 显示文摘	Van Elssen C Frings PWH Bot FJ	2010	Histopathology2010，57，：	1
14	Rapid fluorimetrie determination of phenothiazines employing in situ photochemical oxidation显示文摘	WHITE V R FRINGS C S VILLAFRANCE J E	1976	Anal Chem1976，48，9：	1
15	Decomposing the emotional stroop effect显示文摘	Frings C Englert J Wentura D		0，，01：	1
16	显示文摘	Frings S Meinema H A Van Nostrum C F	1998	Progress in Organic Coatings1998，，33：	1
17	Trial-by-trial effects in the affective priming paradigm显示文摘	Frings C Wentura D		0，，：	1
18	Bioluminescence imag- ing allows measuring CD8 T cell function in the liver显示文摘	Stabenow D Frings M Track C	2010	Hep- atology2010，1，：	1
19	Organic-inorganic hybrid coatings for coil coating application based on polyesters and tetraethoxysilane显示文摘	FRINGS S MEINEMA H A van NOSTRUM C F	1998	Progress in Organic Coatings1998，33，2：	1
20	Remember the Touch: Tactile Distractors Retrieve Previous Responses to Targets 显示文摘	MOELLER B FRINGS C	2011	Ex perimental Brain Research2011，214，1：	1

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