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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | On-road measurement of vehicle tailpipe emissions using a portable instrument显示文摘 | Frey H C Unal A Rouphail N M | 2003 | Journal of the Air and Waste Management Association2003，53，： | 1 |
| 4 | Comparing Real-world Fuel Consumption for Diesel- and Hydrogen-fueled Transit Buses and Implication for Emissions 显示文摘 | FREY H C ROUPHAIL N M ZHAI H | 2007 | Transportation Research Part D2007，12，4： | 1 |
| 5 | Gas phase oxidants of cite smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma : Protective effects of ascorbic acid 显示文摘 | FREI B FOR7I'E T M AMES B N | 1991 | Biochem J1991，277，： | 1 |
| 6 | On-road measurement of vehicle tailpipe emissions using a portable instrument显示文摘 | Frey H C Unal A Rouphail M N | 2003 | Journal of the Air & Waste Management Association2003，53，8： | 1 |
| 7 | Effects of mood stabilizers on DNA damage in an animal model of mania 显示文摘 | Andreazza A C Kauer-Sant'Anna M Frey B N | 2008 | J Psychiatry Neurosci2008，33，6： | 1 |
| 8 | On-road measurement of vehicle tailpipe emissions using a portable instrument 显示文摘 | FREY H UNAL A ROUPHAIL N M | 2003 | Journal of the Air &Waste Management Association2003，53，8： | 1 |
| 9 | Differential expression and function of L-seletion on CD56bright and CD56dim natural killer cell subsets显示文摘 | Frey M Packianathan N B Fehnigeer T A | 1998 | J Immunol1998，161，： | 1 |
| 10 | The composi- tion and function of M cell apical membranes:implications for microbial pathogenesis显示文摘 | NEUTRA M R MANTIS N J FREY A | 1999 | Semin Immunol1999，11，3： | 1 |
| 11 | On-road measurement of vehicle tailpipe emissions using a portable instrument显示文摘 | FREY H UNAL A ROUPHAIL N M | 2003 | J Air Waste Manage Assoc2003，53，： | 1 |
| 12 | Adjuvant chemotherapy of os- teogenic sarcoma: progress and perspectives 显示文摘 | Frei E 3rd Jaffe N Gero M | 1978 | J Natl Cancer Inst1978，60，1： | 1 |
| 13 | Quantification of highway vehicle emissions hot spots based upon on2board measurements显示文摘 | UNAL A FREY H ROUPHAIL N M | 2004 | J Air Waste Manage Assoc2004，54，： | 1 |
| 14 | Gas phase oxidants of cigarette smoke induce lipid peroxidation and changes in lipoprotein properties in human blood plasma:Protective effects of ascorbic acid显示文摘 | FREI B FORTE T M AMES B N | 1991 | Biochem J1991，277，： | 1 |
| 15 | Identification of critical source areas for diffuse water pollution 显示文摘 | Frey M Konz N Stature C | 2011 | Agrarforschung Schweiz2011，2，4： | 1 |
| 16 | Antioxidants and atheroscleroficheart disease显示文摘 | DIAZ M N FREI B VITA J A | 1997 | The New England Journal of Medicine1997，337，： | 1 |
| 17 | Biochemical markers in diagnosis of coronary artery disease显示文摘 | Kampmann M Frey N | 1998 | Eur Heart1998，19，： | 1 |
| 18 | Chimeric antigen receptor modified T cells directed against CD19(CTL019cells)have long-term persistence and induce durable responses in relapsed,refractory CLL显示文摘 | PORTER D KALOS M FREY N V | 2013 | Blood2013，122，： | 1 |
| 19 | Population PKPD modeling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation显示文摘 | FREY N LAVEILLE C PARAIRE M | 2003 | Br J Clin Pharmacol2003，55，2： | 1 |
| 20 | Antioxidants and atherosclerotic heart disease显示文摘 | Epstein F H Diaz M N Frei B Vita J A | 1997 | New England Journal of Medicine1997，337，6： | 1 |
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