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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Rates of change of eigenvalues and eigenvectors显示文摘 | FOX R L KAPOOR M P | 1969 | AIAA Journal1969，6，： | 1 |
| 3 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 4 | Spontaneous deletion of the methicillin resistance determinant,mecA,partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus显示文摘 | Noto M J Fox P M Archer G L | 2008 | Anti micro Agents Chemother2008，52，4： | 1 |
| 5 | Dairy chemistry and biochemistry 显示文摘 | FOX P F MCSWEENEY P L H | 1998 | Blackie Academic Professi-onal1998，，： | 1 |
| 6 | Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition 显示文摘 | Beebe S J Fox P M Rec L J | 2002 | IEEE Trans on Plasma Science2002，30，1： | 1 |
| 7 | Evaluation of realtime PCR for diagnosis of Bordetella pertussis infection显示文摘 | KNORR L FOX J D TILLEY P A | 2006 | BMC Infect Dis2006，，6： | 1 |
| 8 | The effect of N fertilizer source on grain yield, N uptake, soil pH and lime requirement in No-Till Corn 显示文摘 | Fox P H Hoffman L D | 1981 | Agronomy Journal1981，73，5： | 1 |
| 9 | Influence of transglutaminase treatment on some physico-chemical properties of milk 显示文摘 | O' Sullivan M M Kelly A L Fox P F | 2002 | Dairy Research2002，69，： | 1 |
| 10 | Rates of change of eigenvalues and eigenvectors 显示文摘 | R L FOX M P KAPOOR | 1968 | AIAA Journal1968，6，12： | 1 |
| 11 | The dimensionali- ty ofcounter-productivity: Are all counterproductive behav- iors created equal显示文摘 | Spector P E Fox S Penney L M | 2006 | Journal of vocational behavior2006，68，3： | 1 |
| 12 | Long-term cardiovascular mortality after procedure-related or spontaneous myocardial infarction in patients with non-ST-segment elevation acute coronary syndrome: A collaborative analysis of individual patient data from the FRISC II, ICTUS, and RITA-3 Trials ( FIR ) 显示文摘 | Damman P Wallentin L Fox KA | 2012 | Circulation2012，125，4： | 1 |
| 13 | Accelerated Ripening of Cheddar Cheese at Elevated Temperatures显示文摘 | FORKERTSMA B FOX P F MCSWEENEY P L H | 1999 | Dairy Journal1999，6，： | 1 |
| 14 | The Di- mensionality of Counterproductivity: Are All Counterproductive Behaviors Created Equal 显示文摘 | Spector P E Fox S Penney L M Bruursema K Goh A Kessler S | 2006 | Journal of Vocational Behavior2006，，03： | 1 |
| 15 | Nanosecond pulsed electric field(nsPEF) effects on cells and tissues: Apoptosis induction and tumor growth inhibition显示文摘 | Beebe S J Fox P M Rec L J | 2002 | IEEE Transactions on Plasma Science2002，30，1： | 1 |
| 16 | Chemical methods for the characterization of proteolysis in cheese during ripening显示文摘 | MCSWEENEY P L H FOX P F | 1997 | Le Lait1997，77，1： | 1 |
| 17 | Efficacy of transcranial magnetic stimulation targets for depression is related to intrinsic functional connectivity with the subgenual cingulate显示文摘 | Fox M D Buckner R L White M P | 2012 | Biological psychiatry2012，72，7： | 1 |
| 18 | Factors affecting the hydrolytic action of plasmin in milk显示文摘 | CRUDDEN A FOX P F KELLY A L | 2005 | International Dairy Journal2005，15，4： | 1 |
| 19 | Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Moscucci M Fox K A Cannon C P Klein W López-Sendón J Montalescot G | 2003 | Eur Heart J2003，24，： | 1 |
| 20 | Nanosecond pulsed electric field (nsPEF) effects on cells and tissues: apoptosis induction and tumor growth inhibition显示文摘 | Beebe S J Fox P M Rec L J | 2002 | IEEE Transactions on Plasma Science2002，30，1： | 1 |
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