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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology显示文摘 | Morton J. Kern Amir Lerman Jan-Willen Bech Bernard De Bruyne Eric Eeckhout William F. Fearon Stuart T. Higano Michael J. Lim Martijn Meuwissen Jan J. Piek Nico H.J. Pijls Maria Siebes Jos A.E. Spaan | 2006 | Circulation2006，，12： | 3 |
| 3 | Remote Ischemic Preconditioning Reduces Myocardial and Renal Injury After Elective Abdominal Aortic Aneurysm Repair: A Randomized Controlled Trial显示文摘 | Ziad A. Ali Chris J. Callaghan Eric Lim Ayyaz A. Ali S A. Reza Nouraei Asim M. Akthar Jonathan R. Boyle Kevin Varty Rajesh K. Kharbanda David P. Dutka Michael E. Gaunt | 2007 | Circulation ( suppl I)2007，，11： | 1 |
| 4 | PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy显示文摘 | Jing Tan Zhimei Li Puay Leng Lee Peiyong Guan Mei Yee Aau Shuet Theng Lee Min Feng Cheryl Zihui Lim Eric Yong Jing Lee Zhen Ning Wee Yaw Chyn Lim R.K. Murthy Karuturi Qiang Yu | 2013 | Cancer Discovery2013，，10： | 1 |
| 5 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 6 | Enhancement of Stability Following Anterior Cervical Corpectomy: A Biomechanical Study显示文摘 | Kern Singh Alexander R. Vaccaro Jesse Kim Eric P. Lorenz Tae-Hong Lim Howard S. An | 2004 | Spine2004，，8： | 1 |
| 7 | In vitro human digestion models forfood applications显示文摘 | Hur SJ Lim BO Eric A | | 0，，： | 1 |
| 8 | The oral toll-like receptor-7 agonist GS-9620 in patients with chronic hepatitis B virus infection显示文摘 | Edward J. Gane Young-Suk Lim Stuart C. Gordon Kumar Visvanathan Eric Sicard Richard N. Fedorak Stuart Roberts Benedetta Massetto Zhishen Ye Stefan Pflanz Kimberly L. Garrison Anuj Gaggar G. Mani Subramanian John G. McHutchison Shyamasundaran Kottilil Brad | 2015 | Journal of Hepatology2015，，2： | 1 |
| 9 | Type II enteropathy‐associated T‐cell lymphoma: A multicenter analysis from the Asia Lymphoma Study Group显示文摘 | Eric Tse Harinder Gill Florence Loong Seok Jin Kim Siok‐Bian Ng Tiffany Tang Young‐Hyeh Ko Wee‐Joo Chng Soon‐Thye Lim Won Seog Kim Yok‐Lam Kwong | 2012 | Am J Hematol2012，，7： | 1 |
| 10 | Lu- minescent properties of Ruthenium (11)complexes with sterically expansive ligands bound to DNA defects显示文摘 | McConnell Anna J Lim Mi Hee Olmon Eric D | 2012 | In- org Chem2012，51，12： | 1 |
| 11 | In vitro human digestion models for food applications显示文摘 | Sun Jin Hur Beong Ou Lim Eric A. Decker D. Julian McClements | 2010 | Food Chemistry2010，，1： | 1 |
| 12 | The Relationship Between Plasma Osteoprotegerin Levels and Coronary Artery Calcification in Uncomplicated Type 2 Diabetic Subjects显示文摘 | Dhakshinamurthy Vijay Anand Avijit Lahiri Eric Lim David Hopkins Roger Corder | 2006 | Journal of the American College of Cardiology2006，，9： | 1 |
| 13 | 上海天文馆显示文摘上海天文馆坐落于滴水湖畔,总面积约3.8万m^(2)作为上海科技馆分馆,是全球规模最大的天文学主题博物馆。其致力于营造沉浸式体验,让游客可以与各种天文现象直接互动,并通过对比例、形态以及光线的细致处理,提升人们对于太阳和地球轨道运动之间的基本关系的认知。 | 无 V.Guy Maxwell Grace Chen Wei Wei Kuang Charles Wolf Anthony Guaraldo Jorge Arias Margarita Calero Michael Caton Christina Ciardullo Eugene Colberg Regina Jiang Jörg Kiesow Aidan Kim Stefan Knust Xinya Li Francelle Lim Xiaoyun Mao David Monnar Nikita Payusov James Rhee Yong Kyun Roh Miya Ruan Na Sun Eric Tsui Stephanie Tung Charles Wong David Yu Fred Zhang | 2022 | 建筑实践2022，，5： | 1 |
| 14 | Prevalence of Autism Spectrum Disorders in a Total Population Sample显示文摘 | Kim Young Shin Leventhal Bennett L Koh Yun-Joo Fombonne Eric Laska Eugene Lim Eun-Chung Cheon Keun-Ah Kim Soo-Jeong Kim Young-Key Lee HyunKyung Song Dong-Ho Grinker Roy Richard | 2011 | The American Journal of Psychiatry2011，，9： | 1 |
| 15 | Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study显示文摘 | Sandrine Faivre Eric Raymond Eveline Boucher Jean Douillard Ho Y Lim Jun S Kim Magaly Zappa Silvana Lanzalone Xun Lin Samuel DePrimo Charles Harmon Ana Ruiz-Garcia Maria J Lechuga Ann Lii Cheng | 2009 | Lancet Oncology2009，，8： | 1 |
| 16 | Investigation of laser via formation technology for the manufacturing of high density substrates 显示文摘 | Hongyu Zheng Eric Gan Gnian Cher Lim | 2001 | Optics and Lasers in Engineering2001，36，4： | 1 |
| 17 | Hospitalization for variceal hemorrhage in an era with more prevalent cirrhosis显示文摘AIM: To examine hospitalization rates for variceal hemorrhage and relation to cause of cirrhosis during an era of increased cirrhosis prevalence.METHODS: We performed a retrospective review of patients with cirrhosis and gastroesophageal variceal hemorrhage who were admitted to a tertiary care referral center from 1998 to 2009. Subjects were classified according to the etiology of their liver disease: alcoholic cirrhosis and non-alcoholic cirrhosis. Rates of hospitalization for variceal bleeding were determined. Data were also collected on total hospital admissions per year and cirrhosis-related admissions per year over the same time period. These data were then compared and analyzed for trends in admission rates.RESULTS: Hospitalizations for cirrhosis significantly increased from 611 per 100000 admissions in 1998-2001 to 1232 per 100000 admissions in 2006-9(P value for trend < 0.0001). This increase was seen in admissions for both alcoholic and non-alcoholic cirrhosis(P values for trend < 0.001 and < 0.0001 respectively). During the same time period, there were 243 admissions for gastroesophageal variceal bleeding(68% male, mean age 54.3 years, 62% alcoholic cirrhosis). Hospitalizations for gastroesophageal variceal bleeding significantly decreased from 96.6 per 100000 admissions for the time period 1998-2001 to 70.6 per 100000 admissions for the time period 2006-2009(P value for trend = 0.01). There were significant reductions in variceal hemorrhage from non-alcoholic cirrhosis(41.6 per 100000 admissions in 1998-2001 to 19.7 per 100000 admissions in 2006-2009, P value for trend = 0.007). CONCLUSION: Hospitalizations for variceal hemorrhage have decreased, most notably in patients with non-alcoholic cirrhosis, and this may reflect broader use of strategies to prevent bleeding. | Nicholas Lim Michael J Desarno Steven D Lidofsky Eric Ganguly | 2014 | World Journal of Gastroenterology2014，20，32： | 1 |
| 18 | In vitro human digestion models for food applications显示文摘 | Sun Jin Hur Beong Ou Lim Eric A Decker | 2011 | Food Chemistry2011，121，1： | 1 |
| 19 | Angiopoietin-1 and Vascular Endothelial Growth Factor Regulation of Leukocyte Adhesion to Endothelial Cells: Role of Nuclear Receptor-77显示文摘 | Hodan Ismail Mahroo Mofarrahi Raquel Echavarria Sharon Harel Eric Verdin Hyung W. Lim Zheng-Gen Jin Jianxin Sun Huiyan Zeng Sabah N.A. Hussain | 2012 | Arteriosclerosis Thrombosis and Vascular Biology2012，，7： | 1 |
| 20 | Physiological Assessment of Coronary Artery Disease in the Cardiac Catheterization Laboratory: A Scientific Statement From the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology显示文摘 | Morton J. Kern Amir Lerman Jan-Willen Bech Bernard De Bruyne Eric Eeckhout William F. Fearon Stuart T. Higano Michael J. Lim Martijn Meuwissen Jan J. Piek Nico H.J. Pijls Maria Siebes Jos A.E. Spaan | 2006 | Circulation2006，，12： | 1 |
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