|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Short-chain fatty acids act as antiinflammatory mediators by regulating prostaglandin E_2 and cytokines显示文摘AIM:To investigate the effect of short-chain fatty ac-ids (SCFAs) on production of prostaglandin E2 (PGE2),cytokines and chemokines in human monocytes.METHODS:Human neutrophils and monocytes were isolated from human whole blood by using 1-Step Polymorph and RosetteSep Human Monocyte Enrich-ment Cocktail,respectively. Human GPR41 and GPR43 mRNA expression was examined by quantitative real-time polymerase chain reaction. The calcium flux assay was used to examine the biological activities of SCFAs in human neutrophils and monocytes. The effect ofSCFAs on human monocytes and peripheral blood mononuclear cells (PBMC) was studied by measuring PGE2,cytokines and chemokines in the supernatant. The effect of SCFAs in vivo was examined by intraplantar injection into rat paws.RESULTS:Human GPR43 is highly expressed in human neutrophils and monocytes. SCFAs induce robust calcium flux in human neutrophils,but not in human monocytes. In this study,we show that SCFAs can in-duce human monocyte release of PGE2 and that this effect can be enhanced in the presence of lipopolysac-charide (LPS). In addition,we demonstrate that PGE2 production induced by SCFA was inhibited by pertussis toxin,suggesting the involvement of a receptor-mediated mechanism. Furthermore,SCFAs can specifi cally inhibit constitutive monocyte chemotactic protein-1 (MCP-1) production and LPS-induced interleukin-10 (IL-10) production in human monocytes without affecting the secretion of other cytokines and chemokines examined. Similar activities were observed in human PBMC for the release of PGE2,MCP-1 and IL-10 after SCFA treatment. In addition,SCFAs inhibit LPS-induced production of tumor necrosis factor-α and interferon-γ in human PBMC. Finally,we show that SCFAs and LPS can induce PGE2 production in vivo by intraplantar injection into rat paws (P < 0.01). CONCLUSION:SCFAs can have distinct antiinflammatory activities due to their regulation of PGE2,cytokine and chemokine release from human immune cells. | Mary Ann Cox James Jackson Michaela Stanton Alberto Rojas-Triana Loretta Bober Maureen Laverty Xiaoxin Yang Feng Zhu Jianjun Liu Suke Wang Frederick Monsma Galya Vassileva Maureen Maguire Eric Gustafson Marvin Bayne Chuan-Chu Chou Daniel Lundell Chung-Her Jenh | 2009 | World Journal of Gastroenterology2009，15，44： | 30 |
| 2 | The KiSS-1 receptor GPR54 is essential for the development of the murine reproductive system显示文摘 | Sandrine Funes Joseph A Hedrick Galya Vassileva Lisa Markowitz Susan Abbondanzo Andrei Golovko Shijun Yang Frederick J Monsma Eric L Gustafson | 2003 | Biochemical and Biophysical Research Communications2003，，： | 2 |
| 3 | Sub-Hertz relative frequency stabilization of two-diode laser-pumped Nd: YAG lasers locked to a Fabry-Perot interferometer 显示文摘 | Eric K Gustafson Robert L Byer | 1992 | IEEE Journal of Quantum Electronics1992，28，4： | 1 |
| 4 | Quantifying Landscape Spatial Pattern: What Is the State of the Art?显示文摘 | Eric J. Gustafson | 1998 | Ecosystems1998，，2： | 1 |
| 5 | Quantifying Landscape Spatial Pattern: What Is the State of the Art?显示文摘 | Eric J. Gustafson | 1998 | Ecosystems1998，，2： | 1 |
| 6 | Relationships between landcover proportion and indices of landscape spatial pattern显示文摘 | Eric J. Gustafson George R. Parker | 1992 | Landscape Ecology1992，，2： | 1 |
| 7 | P518/Qrfp sequence polymorphisms in SAMP6 osteopenic mouse显示文摘 | Qing Zhang Ping Qiu M. Gladys Arreaza Jason S. Simon Andrei Golovko Maureen Laverty Galya Vassileva Eric L. Gustafson Alberto Rojas-Triana Loretta A. Bober Joseph A. Hedrick Frederick J. Monsma Jonathan R. Greene Marvin L. Bayne Nicholas J. Murgolo | 2007 | Genomics2007，，5： | 1 |
| 8 | Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors显示文摘 | Terrill McClanahan Sandra Koseoglu Kathleen Smith Jeffrey Grein Eric Gustafson Stuart Black Paul Kirschmeier Ahmed A. Samatar | 2006 | Cancer Biology & Therapy2006，，： | 1 |
| 9 | Braid Group Representations from Twisted Tensor Products of Algebras显示文摘We unify and generalize several approaches to constructing braid group representa-tions from finite groups,using iterated twisted tensor products.We provide some general characterizations and classification of these representations,focusing on the size of their images,which are typically finite groups.The well-studied Gaussian representations associated with metaplectic modular categories can be understood in this framework,and we give some new examples to illustrate their ubiquity.Our results suggest a relationship between the braiding on the G-gaugings of a pointed modular category C(A,Q)and that of C(A,Q)itself. | Paul Gustafson Andrew Kimball Eric C.Rowell Qing Zhang | 2020 | Peking Mathematical Journal2020，3，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员