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| 1 | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?显示文摘Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. | Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno Jesús Zacarías Villarreal-Pérez Héctor Jesús Maldonado-Garza | 2016 | World Journal of Gastroenterology2016，22，10： | 12 |
| 2 | Clinical outcomes of compensated and decompensated cirrhosis: A long term study显示文摘AIM: To study these characteristics and prognostic patterns in a Greek patient population.METHODS: We analyzed a large cohort of cirrhotic patients referred to the department of Gastroenterology and Hepatology and the outpatient clinics of this tertiary hospital, between 1991 and 2008. We included patients with established cirrhosis, either compensated or decompensated, and further decompensation episodes were registered. A data base was maintained and updated prospectively throughout the study period.We analyzed differences in cirrhosis aetiology, time to and mode of decompensation, hepatocellular carcinoma(HCC) occurrence and ultimately patient survival.RESULTS: Five hundreds and twenty-two patients with median age 67(range, 29-91) years and average follow up 9 years-10 mo(range, 1-206 mo) were studied. Commonest aetiology was hepatitis C virus(HCV, 41%) followed by alcohol(31%). The median survival time in compensated cirrhotics was 115 mo(95%CI: 95-133), whereas in decompensated patients was 55 mo(95%CI: 36-75). HCV patients survived longer while HBV patients had over twice the risk of death of HCV patients. The median time to decompensation was 65 mo(95%CI: 51-79), with alcoholics having the highest risk(RR = 2.1 vs HCV patients). Hepatitis B virus(HBV) patients had the highest risk of HCC, alcoholics the lowest. Leading causes of death: liver failure, hepatorenal syndrome, sepsis and HCC progression. CONCLUSION: Cirrhosis aetiology and decompensation at presentation were predictors of survival. Alcoholics had the highest decompensation risk, HBV cirrhotics the highest risk of HCC and HCV cirrhotics the highest decompensation-free time. | Dimitrios N Samonakis Mairi Koulentaki Constantina Coucoutsi Aikaterini Augoustaki Chryssavgi Baritaki Emmanuel Digenakis Nikolaos Papiamonis Maria Fragaki Erminia Matrella Elias A Kouroumalis Maria Tzardi | 2014 | World Journal of Hepatology2014，6，7： | 4 |
| 3 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 4 | A Monte-Carlo simulation method for setting the underfrequency load shedding relays and selecting the spinning reserve policy in autonomous power systems显示文摘 | Emmanuel J Thalassinakis Evangelos N Dialynas | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 5 | PRDX4,a member of the peroxiredoxin family,is fused to AML1 (RUNX1) in an acute myeloid leukemia patient with a t (X;21)(p22:q22)显示文摘 | Zhang Y Emmanuel N Kamboj G | 2004 | Genes Chromosomes Cancer2004，40，4： | 1 |
| 6 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gels显示文摘 | Carlos J S Emmanuel D N Andrew F G | 1994 | Biotechniques1994，17，5： | 1 |
| 7 | Robust automatic pa- rallel parking in tight spaces via fuzzy logic 显示文摘 | Zhao Y N Emmanuel G Collins Jr | 2005 | Robotics and Autonomous Systems2005，51，23： | 1 |
| 8 | Does sciatic parasacral injection spread to the obturator nerve an an- atomic study显示文摘 | Nathalie V Jacques R Emmanuel N | 2008 | Anesth Analg2008，106，： | 1 |
| 9 | Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows 显示文摘 | EMMANUEL D G DUNN S M AMETAJ B N | 2008 | J Dairy Sci2008，91，2： | 1 |
| 10 | Comparison of sensory and consumer results with electronic nose and tongue sensors for apple juices显示文摘 | Rebecca N Bleibaum Herbert Stone Tsung Tan Said Labreche Emmanuelle Saint-Martin Sandrine Isz | 2002 | Food Quality and Preference2002，，6： | 1 |
| 11 | Rapid silver staining and recovery of PCR products separated on polyacrylamide gel 显示文摘 | Carlos J S Emmanuel D N Andrew F G | 1994 | Biotechniques1994，17，5： | 1 |
| 12 | Quantitative one-step real-time RT-PCR for the fast detection of the four genotypes of PPRV显示文摘 | Olivier Kwiatek Djénéba Keita Patricia Gil Jovita Fernández-Pinero Miguel Angel Jimenez Clavero Emmanuel Albina Genevieve Libeau | 2010 | Journal of Virological Methods2010，，2： | 1 |
| 13 | Interaction of water-soluble thiolcapped CdTe quantum dots and bovine serum albumin显示文摘 | Mopelola I Emmanuel L Tebello N | 2008 | J PhotochemPhotobiol A2008，198，： | 1 |
| 14 | Precipitation strengthening at ambient and elevated temperatures of heat-treatable AI(Sc) alloys显示文摘 | David N Seidman Emmanuelle A Marquis David C Du- nand | 2002 | Acta Ma- ter2002，50，： | 1 |
| 15 | Opposite regulation of human versus mouse apolipoprotein A-Ⅰ by fibrates in human apolipoprotein A-Ⅰ transgenic mice显示文摘 | BERTHOU L DUVERGER N EMMANUEL F | 1996 | J Clin Invest1996，97，11： | 1 |
| 16 | Activation of Notch-mediated protective signaling in the myocardium显示文摘 | GUDE N A EMMANUEL G WU W | 2008 | Circ Res2008，102，9： | 1 |
| 17 | Dynamic magnetic resonance imaging of the pelvic floor in patients with idiopathic combined fecal and urinary incontinence 显示文摘 | Emmanuel I Egnare M D Panl N | 2004 | Gastrointestinal Surgery2004，8，1： | 1 |
| 18 | Second-generation surveillance for HIV/AIDS in Pakistan:results from the 4th round of integrated behavior and biological survey 2011-2012显示文摘 | Emmanuel F Salim M Akhtar N | 2013 | Sex Transm Infect2013，，893： | 1 |
| 19 | Feeding high proportions of barley grain stimulates an inflammatory response in dairy cows显示文摘 | EMMANUEL D G V DUNN S M AMETAJ B N | 2008 | Journal of Dairy Science2008，91，： | 1 |
| 20 | Screening for adverse pregnancy outcome by ductus venosus Doppler at 11-13+6 weeks of gestation显示文摘 | Maiz N Valencia C Emmanuel EE | | 0，，03： | 1 |
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