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| 1 | Posterior partially edentulous jaws, planning a rehabilitation with dental implants显示文摘AIM: To discuss important characteristics of the useof dental implants in posterior quadrants and the rehabilitation planning. METHODS: An electronic search of English articles was conducted on MEDLINE(PubM ed) from 1990 up to the period of March 2014. The key terms were dental implants and posterior jaws, dental implants/treatment planning and posterior maxilla, and dental implants/treatment planning and posterior mandible. No exclusion criteria were used for the initial search. Clinical trials, randomized and non randomized studies, classical and comparative studies, multicenter studies, in vitro and in vivo studies, case reports, longitudinal studies and reviews of the literature were included in this review. RESULTS: One hundred and fifty-two articles met the inclusion criteria of treatment planning of dental implants in posterior jaw and were read in their entirety. The selected articles were categorized with respect to their context on space for restoration, anatomic considerations(bone quantity and density), radiographic techniques, implant selection(number, position, diameter and surface), tilted and pterygoid implants, short implants, occlusal considerations, and success rates of implants placed in the posterior region. The results derived from the review process were described under several different topic headings to give readers a clear overview of the literature. In general, it was observed that the use of dental implants in posterior region requires a careful treatment plan. It is important that the practitioner has knowledge about the theme to evaluate the treatment parameters. CONCLUSION: The use of implants to restore the posterior arch presents many challenges and requires a detailed treatment planning. | Douglas R Monteiro Emily V F Silva Eduardo P Pellizzer Osvaldo Magro Filho Marcelo C Goiato | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 2 | Methods for the extraction and RNA profiling of exosomes显示文摘AIM:To develop protocols for isolation of exosomes and characterization of their RNA content.METHODS:Exosomes were extracted from He La cell culture media and human blood serum using the Total exosome isolation(from cell culture media)reagent,and Total exosome isolation(from serum)reagent respectively.Identity and purity of the exosomes was confirmed by Nanosight?analysis,electron microscopy,and Western blots for CD63 marker.Exosomal RNA cargo was recovered with the Total exosome RNA and protein isolation kit.Finally,RNA was profiled using Bioanalyzer and quantitative reverse transcriptionpolymerase chain reaction(q RT-PCR)methodology.RESULTS:Here we describe a novel approach for robust and scalable isolation of exosomes from cell culture media and serum,with subsequent isolation and analysis of RNA residing within these vesicles.The isolation procedure is completed in a fraction of the time,compared to the current standard protocols utilizing ultracentrifugation,and allows to recover fully intact exosomes in higher yields.Exosomes were found tocontain a very diverse RNA cargo,primarily short sequences 20-200 nt(such as mi RNA and fragments of m RNA),however longer RNA species were detected as well,including full-length 18S and 28S r RNA.CONCLUSION:We have successfully developed a set of reagents and a workflow allowing fast and efficient extraction of exosomes,followed by isolation of RNA and its analysis by q RT-PCR and other techniques. | Emily Zeringer Mu Li Tim Barta Jeoffrey Schageman Ketil Winther Pedersen Axl Neurauter Susan Magdaleno Robert Setterquist Alexander V Vlassov | 2013 | World Journal of Methodology2013，3，1： | 5 |
| 3 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 4 | Tissue structure and connexin expression of cannie pulmonary veins显示文摘 | Sander V Emily E | 2002 | Cardiovasc Res2002，55，： | 1 |
| 5 | Volumetric modulated arc therapy for delivery of prostate radiotherapy: Comparison with intensity-modulat- ed radiotherapy and three-dimensional conformal radiotherapy显示文摘 | David P Emily V Kerry J | 2008 | Int J Radiat Oncol Biol Phys2008，72，4： | 1 |
| 6 | Sequential interval motif search:unrestricted database surveys of global MS/MS data sets for detection of putative post-translational modifications显示文摘 | Liu J Erassov A Halina P Canete M Nguyen D V Chung C Cagney G Ignatchenko A Fong V Emili A | | 0，，20： | 1 |
| 7 | Optimization of magnetic powdered activated carbon for aqueous Hg (Ⅱ) removal and magnetic recovery显示文摘 | Emily K Faulconer Natalia V Hoogesteijn von Reitzenstein David W Mazyck | 2012 | J Hazard Mater2012，，3： | 1 |
| 8 | Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate显示文摘AIM: To evaluate the feasibility of using therapeutic ultrasound as an alternative treatment option for organconfined prostate cancer. METHODS: In this study, a trans-urethral therapeutic ultrasound applicator in combination with 3T magnetic resonance imaging(MRI) guidance was used for realtime multi-planar MRI-based temperature monitoring and temperature feedback control of prostatic tissue thermal ablation in vivo. We evaluated the feasibility and safety of MRI-guided trans-urethral ultrasound to effectively and accurately ablate prostate tissue while minimizing the damage to surrounding tissues in eight canine prostates. MRI was used to plan sonications, monitor temperature changes during therapy, and to evaluate treatment outcome. Real-time temperature and thermal dose maps were calculated using the proton resonance frequency shift technique and were displayed as two-dimensional color-coded overlays on top of the anatomical images. After ultrasound treatment, an evaluation of the integrity of cavernosal nerves was performed during prostatectomy with a nerve stimulator that measured tumescence response quantitatively and indicated intact cavernous nerve functionality. Planned sonication volumes were visually correlated to MRI ablation volumes and corresponding histo-pathological sections after prostatectomy. RESULTS: A total of 16 sonications were performed in 8 canines. MR images acquired before ultrasound treatment were used to localize the prostate and to prescribe sonication targets in all canines. Temperature elevations corresponded within 1 degree of the targeted sonication angle, as well as with the width and length of the active transducer elements. The ultrasound treatment procedures were automatically interrupted when the temperature in the target zone reached 56 ℃. In all canines erectile responses were evaluated with a cavernous nerve stimulator post-treatment and showed a tumescence response after stimulation with an electric current. These results indicated intact cavernous nerve functionality. In all specimens, regions of thermal ablation were limited to areas within the prostate capsule and no damage was observed in periprostatic tissues. Additionally, a visual analysis of the ablation zones on contrast-enhanced MR images acquired post ultrasound treatment correlated excellent with the ablation zones on thermal dose maps. All of the ablation zones received a consensus score of 3(excellent) for the location and size of the correlation between the histologic ablation zone and MRI based ablation zone. During the prostatectomy and histologic examination, no damage was noted in the bladder or rectum.CONCLUSION: Trans-urethral ultrasound treatment of the prostate with MRI guidance has potential to safely, reliably, and accurately ablate prostatic regions, while minimizing the morbidities associated with conventional whole-gland resection or therapy. | Steffen Sammet Ari Partanen Ambereen Yousuf Christina L Sammet Emily V Ward Craig Wardrip Marek Niekrasz Tatjana Antic Aria Razmaria Keyvan Farahani Shunmugavelu Sokka Gregory Karczmar Aytekin Oto | 2015 | World Journal of Radiology2015，7，12： | 1 |
| 9 | Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells 显示文摘 | Emilie S Celine V T Kim L | 2006 | Mol Cancer2006，5，： | 1 |
| 10 | Cost-effectiveness of Crohn's disease post-operative care显示文摘AIM: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn's disease following intestinal resection.METHODS: In the 'POCER' study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care(6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy. Colonoscopy at 18 mo and faecal calprotectin(FC) measurement were used to assess disease recurrence. Administrative data, chart review and patient questionnaires were collected prospectively over 18 mo.RESULTS: Sixty patients(active care n = 43, standardcare n = 17) were included from one health service. Median total health care cost was $6440 per patient. Active care cost $4824 more than standard care over 18 mo. Medication accounted for 78% of total cost, of which 90% was for adalimumab. Median health care cost was higher for those with endoscopic recurrence compared to those inremission [ $ 26347( IQR 25045-27485) vs $2729(IQR 1182-5215), P < 0.001]. FC to select patients for colonoscopy could reduce cost by $1010 per patient over 18 mo. Active care was associated with 18% decreased endoscopic recurrence, costing $861 for each recurrence prevented. CONCLUSION: Post-operative management strategies are associated with high cost, primarily medication related. Calprotectin use reduces costs. The long term cost-benefit of these strategies remains to be evaluated. | Emily K Wright Michael A Kamm Peter Dr Cruz Amy L Hamilton Kathryn J Ritchie Sally J Bell Steven J Brown William R Connell Paul V Desmond Danny Liew | 2016 | World Journal of Gastroenterology2016，22，14： | 1 |
| 11 | Evaluation of chiral ionic liquids as additives to cyclodextrins for en- antiomeric separations by capillary electrophoresis 显示文摘 | YANNIS F ANN V EMILIE J | 2007 | Chromatography A2007，1155，： | 1 |
| 12 | Validity of Physical activity Intensity Predic- tions by Actigraph, Actical, and RT3 Accelerometers显示文摘 | MEGAN P ROTHNEY EMILY V SCHAEFER MEGAN M LEENA | 2008 | Obesity (Silver Spring)2008，16，8： | 1 |
| 13 | Predicing parenting stress in camgivers of children with brain tumours显示文摘 | Emily B Matin V Micnael R | 2012 | Psycho-Oncology2012，22，： | 1 |
| 14 | Deletion 2q36.2q36.3 with multiple renal cysts and severe mental retardation显示文摘 | Martine Doco-Fenzy Emilie Landais Joris Andrieux Anouck Schneider Brigitte Delemer Véronique Sulmont Jean-Pierre Melin Dominique Ploton Jessica Thevenard Jean-Claude Monboisse Mohamed Belouadah Francis Lefebvre Anne Durlach Michel Goossens Juliette Albuis | 2008 | European Journal of Medical Genetics2008，，6： | 1 |
| 15 | Hydroxyl radical production by ascorbate and hydrogen peroxide显示文摘 | Anthonyj N Emily V | 2000 | Neurotoxicity Research2000，2，4： | 1 |
| 16 | Secondary muta tions as a mechanism of cisplatin resistance in BRCA2 mutated cancers 显示文摘 | Wataru S Cynthia F Emily V | 2008 | Nature2008，451，28： | 1 |
| 17 | Interleukin-6 biosynthesis in human preovulatory follicles: some of its potential roles at ovula- tion显示文摘 | Machelon V Emilie D Lefevre A | 1994 | J Clini Endocrinol Metabol1994，79，2： | 1 |
| 18 | Crities and health: History approaches and key questions显示文摘 | David V Emily G Nicholas F | 2004 | Academic Medicine2004，79，12： | 1 |
| 19 | CFD Analysis of a 15% circulation controlled elliptical 显示文摘 | Z Henry I V Graharm Gerald M Angle II Emily D Peal Mary Ann Clarke James E Smith | 2011 | International Journal of Research and Reviews in Computer Science2011，2，2： | 1 |
| 20 | Synergistic effects of COC12 and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells显示文摘 | Emilie P Helene L Samuel V | 2006 | J Cell Sci2006，119，13： | 1 |
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