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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Towards precision medicine:advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy显示文摘Robust and clinically convenient biomarkers for cancer diagnosis,early detection,and prognosis have great potential to improve patient survival and are the key to precision medicine.The advent of next-generation sequencing technologies enables a more sensitive and comprehensive profiling of genetic and epigenetic information in tumor-derived materials.Researchers are now able to monitor the dynamics of tumorigenesis in new dimensions,such as using circulating cell-free DNA(cfDNA)and tumor DNA(ctDNA).Mutation-based assays in liquid biopsy cannot always provide consistent results across studies due partly to intra-and inter-tumoral heterogeneity as well as technical limitations.In contrast,epigenetic analysis of patient-derived cfDNA is a promising alternative,especially for early detection and disease surveillance,because epigenetic modifications are tissue-specific and reflect the dynamic process of cancer progression.Therefore,cfDNA-based epigenetic assays are emerging to be a highly sensitive,minimally invasive tool for cancer diagnosis and prognosis with great potential in future precise care of cancer patients.The major obstacle for applying epigenetic analysis of cfDNA,however,has been the lack of enabling techniques with high sensitivity and technical robustness.In this review,we summarized the advances in epigenome-wide profiling of 5-hydroxymethyl-cytosine(5hmC)in cfDNA,focusing on the detection approaches and potential role as biomarkers in different cancer types. | Chang Zeng Emily Kunce Stroup Zhou Zhang Brian C-HChiu Wei Zhang | 2019 | Cancer Communications2019，39，1： | 7 |
| 3 | Recent progress in the genetics of diabetic microvascular complications显示文摘Diabetic complications including diabetic nephropathy,retinopathy,and neuropathy are as major causes of morbidity and mortality in diabetes individuals worldwide and current therapies are still unsatisfactory.One of the reasons for failure to develop effective treatment is the lack of fundamental understanding for underlying mechanisms.Genetic studies are powerful tools to dissect disease mechanism.The heritability(h2) was estimated to be 0.3-0.44 for diabetic nephropathy and 0.25-0.50 for diabetic retinopathy respectively.Previous linkage studies for diabetic nephropathy have identified overlapped linkage regions in 1q43-44,3q21-23,3q26,10p12-15,18q22-23,19q13,22q11-12.3 in multiple ethnic groups.Genome-wide association studies(GWAS) of diabetic nephropathy have been conducted in several populations.However,most of the identified risk loci could not be replicated by independent studies with a few exceptions including those in ELMO1,FRMD3,CARS,MYO16/IRS2,and APOL3-MYH9 genes.Functional studies of these genes revealed the involvement of cytoskeleton reorganization(especially non-muscle type myosin),phagocytosis of apoptotic cells,fibroblast migration,insulin signaling,and epithelial clonal expansion in the pathogenesis of diabetic nephropathy.Linkage analyses of diabetic retinopathy overlapped only in 1q36 region and current results from GWAS for diabetic retinopathy are inconsistent.Conclusive results from genetic studies for diabetic neuropathy are lacking.For now,small sample sizes,confounding by population stratification,different phenotype definitions between studies,ethnic-specific associations,the influence of environmental factors,and the possible contribution of rare variants may explain the inconsistencies between studies. | Yi-Cheng Chang Emily Yun-Chia Chang Lee-Ming Chuang | 2015 | World Journal of Diabetes2015，6，5： | 7 |
| 4 | Physiological levels of ATP negatively regulate proteasome function显示文摘由 ubiquitin-proteasome 系统的细胞内部的蛋白质降级是 ATP 依赖者,和最佳的 ATP 集中激活 proteasome 在 vitro 的功能是 ~ 100 渭 M。细胞内部的 ATP 层次在在这个范围以内的水平通常在低 millimolar 范围,而是 ATP 被显示在 vitro 禁止 proteasome peptidase 活动。这里,我们报导支持在生理的层次的细胞内部的 ATP 双向地调整的一个假设的新证据 26S proteasome 在房间的解朊的功能。首先,我们证实 ATP 在 vitro 在 26S proteasome 上施加了双向规定,与最佳的 ATP 集中(在 50 和 100 渭 M 之间) 刺激 proteasome 像糜蛋白酶的活动。第二,我们发现操作细胞内部的 ATP 层次也在有教养的房间在 proteasome 特定的蛋白质底层的层次导致了双向变化。最后,测量增加提高的细胞内部的 ATP,当减少的细胞内部的 ATP 稀释了导致房间死亡的 proteasome 抑制的能力时。这些数据强烈建议在生理的集中范围以内的内长的 ATP 能在 proteasome 活动施加否定影响,允许房间到很快,在应力下面的 ATP 减小上的 upregulate proteasome 活动调节。 | Hongbiao Huang Xiaoyan Zhang Shujue Li Ningning Liu Wen Elan Emily McDowell Ping Zhou Canguo Zhao Haiping Guo Change Zhang Changshan Yang Guangmei Wen Xiaoxian Dong Li Lu Ningfang Ma Weihua Dong Q Ping Dou Xuejun Wang Jinbao Liu | 2010 | Cell Research2010，20，12： | 4 |
| 5 | Transfers from Older Parents to Their Adult Children in Taiwan and the Philippines显示文摘 | Emily M. Agree Ann E. Biddlecom Ming-Cheng Chang Aurora E. Perez | 2002 | Journal of Cross - Cultural Gerontology2002，，4： | 1 |
| 6 | Risk of Thromboembolism Following Acute Intracerebral Hemorrhage显示文摘 | Joshua N. Goldstein Louis E. Fazen Lauren Wendell Yuchiao Chang Natalia S. Rost Ryan Snider Kristin Schwab Rishi Chanderraj Christopher Kabrhel Catherine Kinnecom Emilie FitzMaurice Eric E. Smith Steven M. Greenberg Jonathan Rosand | 2009 | Neurocritical Care2009，，1： | 1 |
| 7 | Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)显示文摘 | Jessica R. Chang Euna Koo Elvira Agrón Joelle Hallak Traci Clemons Dimitri Azar Robert D. Sperduto Frederick L. Ferris Emily Y. Chew | 2011 | Ophthalmology2011，，11： | 1 |
| 8 | A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma显示文摘 | Andrew H. Ko Noelle LoConte Margaret A. Tempero Evan J. Walker R. Kate Kelley Stephanie Lewis Wei-Chou Chang Emily Kantoff Michael W. Vannier Daniel V. Catenacci Alan P. Venook Hedy L. Kindler | 2016 | Pancreas2016，，3： | 1 |
| 9 | Prediction of Functional Outcome in Patients With Primary Intracerebral Hemorrhage: The FUNC Score显示文摘 | Natalia S. Rost Eric E. Smith Yuchiao Chang Ryan W. Snider Rishi Chanderraj Kristin Schwab Emily FitzMaurice Lauren Wendell Joshua N. Goldstein Steven M. Greenberg Jonathan Rosand | 2008 | Stroke2008，，8： | 1 |
| 10 | Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy显示文摘 | Jia Xiao Rui Guo Man-Lung Fung Emily C. Liong Raymond Chuen Chung Chang Yick-Pang Ching George L. Tipoe Yueh-Sheng Chen | 2013 | <journal-title>Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 11 | Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice显示文摘 | Chang Tiffany Krisman Kimberly Theobald Emily Harding Xu Jin Akutagawa Jon Lauchle Jennifer O Kogan Scott Braun Benjamin S Shannon Kevin | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 12 | Subterfuge and Manipulation: Type III Effector Proteins of Phytopathogenic Bacteria显示文摘 | Sarah R. Grant Emily J. Fisher Jeff H. Chang Beth M. Mole Jeffery L. Dangl | 2006 | Annual Review of Microbiology2006，，： | 1 |
| 13 | Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice显示文摘 | Jenna C Carroll Emily R Rosario Lilly Chang | 2007 | J Neurosci2007，27，13： | 1 |
| 14 | Small-scale forest carbon projects: Adapting CDM to low-income communities显示文摘 | Emily Boyd Mafia Gutierrez Manyu Chang | 2007 | Global Environmental Change2007，17，2： | 1 |
| 15 | Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta显示文摘Osteogenesis imperfecta(OI) comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B(ACVR2B) in a mouse model of type Ⅲ OI(oim). Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system. | Douglas J DiGirolamo Vandana Singhal Xiaoli Chang Se-Jin Lee Emily L Germain-Lee | 2015 | Bone Research2015，3，1： | 1 |
| 16 | Deep brain stimulation induces BOLD activation in motor and non-motor networks: An fMRI comparison study of STN and EN/GPi DBS in large animals显示文摘 | Hoon-Ki Min Sun-Chul Hwang Michael P. Marsh Inyong Kim Emily Knight Bryan Striemer Joel P. Felmlee Kirk M. Welker Charles D. Blaha Su-Youne Chang Kevin E. Bennet Kendall H. Lee | 2012 | Neuroimage2012，，3： | 1 |
| 17 | Modulating the frequency and bias of stochastic switching to control phenotypic variation 显示文摘 | Hung Michelle Chang Emily Hussein R | 2014 | Nat Commun2014，5，： | 1 |
| 18 | Small-scale Forest Carbon Proiects: Adapting CDM to Low-income Communities 显示文摘 | Emily Boyd Maria Gutierrez Manyu Chang | 2007 | Global Environmental Change2007，17，2： | 1 |
| 19 | Instability of gold oxide Au 2 O 3显示文摘 | Hungchun Tsai Emily Hu Kuoguang Perng Minkar Chen Jung-Chun Wu Yee-Shyi Chang | 2003 | Surface Science2003，，1： | 1 |
| 20 | Ten-Year Incidence Rates of Age-Related Cataract in the Age-Related Eye Disease Study (AREDS): AREDS Report No. 33显示文摘 | Euna Koo Jessica R. Chang Elvira Agrón Traci E. Clemons Robert D. Sperduto Frederick L. Ferris Emily Y. Chew | 2013 | Ophthalmic Epidemiology2013，，2： | 1 |
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