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| 1 | Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation显示文摘AIM: To investigate coping mechanisms, constipation symptoms and anorectal physiology in 80 constipated subjects and 18 controls.METHODS: Constipation was diagnosed by Rome Ⅱ criteria.Coping ability and anxiety/depression were assessed by validated questionnaires. Transit time and balloon distension test were performed.RESULTS: 34.5% patients were classified as slow transit type of constipation. The total colonic transit time (56 h vs 10 h, P<0.0001) and rectal sensation including urge sensation (79 mL vs 63 mL, P = 0.019) and maximum tolerable volume (110 mL vs95 mL, P = 0.03) differed in patients and controls. Constipated subjects had significantly higher anxiety and depression scores and lower SF-36 scores in all categories. They also demonstrated higher scores of'monitoring' coping strategy (14+6 vs9+3, P = 0.001),which correlated with the rectal distension sensation (P = 0.005), urge sensation (P=0.002), and maximum tolerable volume (P = 0.035). The less use of blunting strategy predicted slow transit constipation in both univariate (P = 0.01) and multivariate analysis (P = 0.03).CONCLUSION: Defective or ineffective use of coping strategies may be an important etiology in functional constipation and subsequently reflected in abnormal anorectal physiology. | Annie OO Chan Cecilia Cheng Wai Mo Hui Wayne HC Hu Nina YH Wong KF Lam Wai Man Wong Kam Chuen Lai Shiu Kum Lam Benjamin CY Wong | 2005 | World Journal of Gastroenterology2005，11，34： | 92 |
| 2 | Enabling Industrial Internet of Things(IIoT) towards an emerging smart energy system显示文摘The increasing penetration of renewable energy on the transmission and distribution power network is driving the adoption of two-way power flow control, data and communications needed to meet the dependency of balancing generation and load. Thus, creating an environment where power and information flow seamlessly in real time to enable reliable and economically viable energy delivery, the advent of Internet of Energy(IoE) as well as the rising of Internet of Things(IoT) based smart systems.The evolution of IT to Io T has shown that an information network can be connected in an autonomous way via routers from operating system(OS) based computers and devices to build a highly intelligent eco-system. Conceptually, we are applying the same methodology to the Io E concept so that Energy Operating System(EOS) based assets and devices can be developed into a distributed energy network via energy gateway and self-organized into a smart energy eco-system.This paper introduces a laboratory based IIo T driven software and controls platform developed on the NICE Nano-grid as part of a NICE smart system Initiative for Shenhua group. The goal of this effort is to develop an open architecture based Industrial Smart Energy Consortium(ISEC) to attract industrial partners, academic universities, module supplies, equipment vendors and related stakeholder to explore and contribute into a test-bed centric open laboratory template and platform for next generation energy-oriented smart industry applications.In the meanwhile, ISEC will play an important role to drive interoperability standards for the mining industry so that the era of un-manned underground mining operation can become the reality as well as increasing safety regulation enforcement. | Ding Zhang Ching Chuen Chan George You Zhou | 2018 | Global Energy Interconnection2018，1，1： | 9 |
| 3 | Whole-system thinking, development control, key barriers and promotion mechanism for EV development显示文摘Electric vehicles(EVs)have received significant attention because of the potential energy savings and emission reductions they enable.However,current studies and demonstrations have focused mainly on specific technologies and equipment types,which cannot in themselves solve the predicaments facing EVs.This study points out that EVs will form a large,complex system that needs to be optimized over different aspects to compete with traditional vehicles.Therefore,wholesystem thinking is needed to support the development control of EVs,with a broader scope than operational control,and the core issue is the interaction between EVs and power grid,including their coordinated development and operational management.For development control of EVs,a target system and a step-wise optimization method are presented,as well as the basic principles for designing the target system.There are two key barriers in EVs’development:the research and mass production of highperformance power batteries,and the formulation of a favorable mechanism to capture benefits and encourage development.To address the problems of EV development,a promotion method that combines franchising with moderate competition is proposed.The concepts and methods developed in this study can facilitate the research and development of EVs. | Chunlin GUO Ching Chuen CHAN | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，2： | 9 |
| 4 | Optimal Investment and Premium Control in a Nonlinear Diffusion Model显示文摘This paper considers the optimal investment and premium control problem in a diffusion approximation to a non-homogeneous compound Poisson process. In the nonlinear diffusion model, it is assumed that there is an unspecified monotone function describing the relationship between the safety loading of premium and the time-varying claim arrival rate. Hence, in addition to the investment control, the premium rate can be served as a control variable in the optimization problem. Specifically, the problem is investigated in two cases:(i) maximizing the expected utility of terminal wealth, and(ii) minimizing the probability of ruin respectively.In both cases, some properties of the value functions are derived, and closed-form expressions for the optimal policies and the value functions are obtained. The results show that the optimal investment policy and the optimal premium control policy are dependent on each other. Most interestingly, as an example, we show that the nonlinear diffusion model reduces to a diffusion model with a quadratic drift coefficient when the function associated with the premium rate and the claim arrival rate takes a special form. This example shows that the model of study represents a class of nonlinear stochastic control risk model. | Ming ZHOU Kam Chuen YUEN Chuan-cun YIN | 2017 | Acta Mathematicae Applicatae Sinica2017，33，4： | 4 |
| 5 | Polo-like kinase 1,a new therapeutic target in hepatocellular carcinoma显示文摘AIM:To investigate the role of polo-like kinase 1 (PLK1) as a therapeutic target for hepatocellular carcinoma (HCC).METHODS:PLK1 gene expression was evaluated in HCC tissue and HCC cell lines.Gene knockdown with short-interfering RNA (siRNA) was used to study PLK1 gene and protein expression using real-time reverse transcription polymerase chain reaction (RT-PCR) and Western blotting,and cell proliferation using 3-(4,5-dim ethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2(4-sulf ophenyl)-2H-tetrazolium (MTS) and bromodeoxyuridine (BrdU) assays.Apoptosis was evaluated using the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay,and caspase-inhibition assay.Huh-7 cells were transplanted into nude mice and co-cultured with PLK1 siRNA or control siRNA,and tumor progression was compared with controls.RESULTS:RT-PCR showed that PLK1 was overexpressed 12-fold in tumor samples compared with controls,and also was overexpressed in Huh-7 cells.siRNA against PLK1 showed a reduction in PLK1 gene and protein expression of up to 96% in Huh-7 cells,and a reduction in cell proliferation by 68% and 92% in MTS and BrdU cell proliferation assays,respectively.There was a 3-fold increase in apoptosis events,and TUNEL staining and caspase-3 assays suggested that this was caspase-independent.The pan-caspase inhibitor Z-VAD-FMK was unable to rescue the apoptotic cells.Immnofluorescence co-localized endonuclease-G to fragmented chromosomes,implicating it in apoptosis.Huh-7 cells transplanted subcutaneously into nude mice showed tumor regression in siPLK1-treated mice,but not in controls.CONCLUSION:Knockdown of PLK1 overexpression in HCC was shown to be a potential therapeutic target,leading to apoptosis through the endonuclease-G pathway. | Wei Chuen Mok Shanthi Wasser Theresa Tan Seng Gee Lim | 2012 | World Journal of Gastroenterology2012，18，27： | 4 |
| 6 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 7 | Early-onset primary torsional dystonia in a 4-generation Chinese family with a mutation in the DYT1 gene显示文摘Primary torsion dystonia (PTD) is a clinically and genetically heterogeneous movement disorder. At least thirteen different types of dystonia can be distinguished on a genetic basis.1 The DYT1 gene was first mapped by Ozelius et al in 1989.2 (Kramer et) al3 linked the same locus to PTD in 12 Ashkenazi Jewish families in 1990. Most patients with early-onset generalized PTD were caused by the same three base pair (GAG) deletion in the DYT1 gene on chromosome 9q34.1,4,5 The product of the gene is a protein called torsinA.5 (Although the) function of this protein is as yet uncertain, it is widely distributed throughout the brain with high levels in the substantia nigra compacta dopamine neurones. | YEUNG Wai Lan LAM Ching Wan CHENG Wai Tsoi SIN Ngai Chuen WONG Wing Kin WONG Chun Nei TSE Ka Ming FOK Tai Fai | 2005 | Chinese Medical Journal2005，，10： | 2 |
| 8 | Asymptotic Results for Tail Probabilities of Sums of Dependent and Heavy-Tailed Random Variables显示文摘Let X1, X2, ··· be a sequence of dependent and heavy-tailed random variables with distributions F1, F2, ··· on (?∞, ∞), and let τ be a nonnegative integer-valued ran-dom variable independent of the sequence {Xk, k ≥ 1}. In this framework, the asymptotic behavior of the tail probabilities of the quantities Sn = n k=1 X k and S(n) = max1 ≤k≤n Sk for n > 1, and their randomized versions Sτ and S(τ) are studied. Some applications to the risk theory are presented. | Kam Chuen YUEN Chuancun YIN | 2012 | Chinese Annals of Mathematics,Series B2012，33，4： | 2 |
| 9 | Alternative Approach to the Optimality of the Threshold Strategy for Spectrally Negative Lvy Processes显示文摘Consider the optimal dividend problem for an insurance company whose uncontrolled surplus precess evolves as a spectrally negative Lvy process. We assume that dividends are paid to the shareholders according to admissible strategies whose dividend rate is bounded by a constant. The objective is to find a dividend policy so as to maximize the expected discounted value of dividends which are paid to the shareholders until the company is ruined. In this paper, we show that a threshold strategy(also called refraction strategy)forms an optimal strategy under the condition that the Lvy measure has a completely monotone density. | Ying SHEN Chuan-cun YIN Kam Chuen YUEN | 2013 | Acta Mathematicae Applicatae Sinica2013，29，4： | 2 |
| 10 | Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?显示文摘AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.
METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.
RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients thanH.pylori-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.
CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection. | Harry Hua-Xinag Xia Shiu Kum Lam Wai Man Wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing Wong Suet Yi Leung Siu Tsan Yuen Nicholas A.Wright Benjamin Chun-Yu Wong | 2003 | World Journal of Gastroenterology2003，9，6： | 2 |
| 11 | Fuzzy Logical in Control System:Fuzzy Logical Controller Part I 显示文摘 | Chuen Chzen Lee | 1990 | IEEE Trans on System Man Cybernetics1990，20，2： | 1 |
| 12 | Gender differences in the trend of colorectal cancer incidence in Singapore, 1968–2002显示文摘 | Inge M. C. M. Kok Chia Siong Wong Kee Seng Chia Xueling Sim Chuen Seng Tan Lambertus A. Kiemeney Helena M. Verkooijen | 2008 | International Journal of Colorectal Disease2008，，5： | 1 |
| 13 | Size-controlled Hydroxyapatite Nanoparticles as Self-organize Organic-inorganic Composite Materials显示文摘 | Viorel M R Chuen H N Max W | 2005 | Biomaterials2005，26，26： | 1 |
| 14 | Clinical applications of thyroid ultrasonography显示文摘 | Jen-Der Lin M D Chuen Hsueh M D Feng-Hsuan Liu M D | 2006 | The Endocrinologist2006，16，31： | 1 |
| 15 | Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 16 cases in Taiwan显示文摘 | Shih-Ming Jung Pei-Yeh Chang Chih-Cheng Luo Chen-Sheng Huang Jin-Yao Lai Chuen Hsueh | 2005 | Pediatric Surgery International2005，，10： | 1 |
| 16 | A look-ahead synthesis technique with backtracking for switching activity reduction in low power high-level synthesis显示文摘 | Xing Xianwu Ching Chuen Jong | 2007 | Microelectronics Journal2007，38，45： | 1 |
| 17 | Recovery of isopropyl alcohol fromwaste solvent of a semiconductor plant显示文摘 | Lin S H Wang Chuen S | 2004 | Hazardous Materi-als2004，106，23： | 1 |
| 18 | Full X–Ku band microwave absorption by Fe(Mn)/Mn 7 C 3 /C core/shell/shell structured nanocapsules显示文摘 | Xianguo Liu Siu Wing Or S.L. Ho Chi Chuen Cheung Chung Ming Leung Zheng Han Dianyu Geng Zhidong Zhang | 2011 | Journal of Alloys and Compounds2011，，37： | 1 |
| 19 | fuzzy logic in control systems: fuzzy logic controller- part Ⅰ 显示文摘 | CHUEN CHIEN LEE | 1990 | IEEE trans on system man and cybernetics1990，20，2： | 1 |
| 20 | High precision z3Th2Th and zUsU measurements using energy filtered ICP magnetic sector multiple collector mass spectrometry显示文摘 | Xiaozhong Luo Mark Rehkamper Der'-Chuen Lee | 1997 | International Journal of Mass Spectrometry and Ion Processes1997，171，： | 1 |
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