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| 1 | Identification and expansion of human colon-cancer-initiating cells显示文摘 | LUCIA R V DARIO G L EMANUELA P | 2007 | Nature2007，445，： | 1 |
| 2 | Low complexity carrier-to-noise ratio estimators for GNSS digital recei- vers显示文摘 | Emanuela F Marco P Letizia L P | 2011 | IEEE Transactions on Aerospace and Electronic Systems2011，47，1： | 1 |
| 3 | Inflammation as a link between obesity and metabolic syndrome 显示文摘 | Emanuela FGM Marco de R Maria Paola L | 2012 | J Nutr Metab2012，2012，47： | 1 |
| 4 | Influence of severe plastic deformation on aging of AI-Mg-Si alloys显示文摘 | Emanuela C Paola L | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 5 | Social Networking and Inequality:the Role of Clustered Networks显示文摘 | Emanuela D A Marco l | 2011 | Cambridge Journal of Regions Economy and Society2011，4，1： | 1 |
| 6 | The A19G polymorphism in the 5'untranslated region of the human obese gene does not affect leptin levels in severely obese patients 显示文摘 | Rossana L Emanuela P Maria EB | 2000 | J Clin Endocrinol Metab2000，85，10： | 1 |
| 7 | Mucinous low-grade adenocarcinoma arising in an intracranial enterogenouscyst: case report 显示文摘 | Marco G Federico G L? Emanuela M | 2008 | Neurosurgery2008，62，4： | 1 |
| 8 | Interleukin-6 impairs the insulin signaling pathway, promoting production of nitric oxide in human umbilical vein endothelial cells 显示文摘 | Francesco A Emanuela L Cristina P | 2007 | Mol Cell Biol2007，27，： | 1 |
| 9 | SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine显示文摘 | Warren S Alexander Robyn Starr Jennifer E Fenner Clare L Scott Emanuela Handman Naomi S Sprigg Jason E Corbin Ann L Cornish Rima Darwiche Catherine M Owczarek Thomas W.H Kay Nicos A Nicola Paul J Hertzog Donald Metcalf Douglas J Hilton | 1999 | Cell1999，，5： | 1 |
| 10 | Home-based versus in- hospital cardiac rehabilitation after cardiac surgery: a nonrandomized controlled study显示文摘 | Simonetta S Emanuela Z Comini L | 2013 | Physical Therapy2013，12，17： | 1 |
| 11 | Social Networking and Ine-quality :The Role of Clustered Networks显示文摘 | Emanuela D A Marco L | 2011 | CambridgeJournal of Regions Economy and Society2011，4，1： | 1 |
| 12 | Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker显示文摘 | Ray Partha Rialon-Guevara Kristy L Veras Emanuela Sullenger Bruce A White Rebekah R | 2012 | EN2012，，5： | 1 |
| 13 | Energetic materials: crystallization, characterization and insensitive plastic bonded explosives显示文摘 | van der Heijden A E D M Creyghton Y L M Emanuela M | 2008 | Propellants Explosives Pyrotechnics2008，33，1： | 1 |
| 14 | 显示文摘 | Stefano M Emanuela L Laura C | 1999 | Pure and Applied Chemistry1999，71，8： | 1 |
| 15 | Role of nitric oxide in angiogenesis and tumor progression in head and neck cancer 显示文摘 | Gallo O Emanuela M Morbidelli L | 1998 | J Natl Cancer Inst1998，90，8： | 1 |
| 16 | Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study显示文摘The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation properties.Herein,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of CIGB-814.We found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide oligomers.Subsequently,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics. | Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa Maria Del Carmen Domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso Mariano Venanzi | 2022 | ChemPhysMater2022，1，1： | 0 |
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