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| 1 | Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy显示文摘AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers(m CRCs) addicted to epidermal growth factor receptor(EGFR) signalling.METHODS: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting m CRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of Pub Med, Medline and Web of Science to identify eligible papers until March 21 st, 2016 using these following terms: ‘‘colorectal cancer'', 'predictive biomarkers' ', 'anti-EGFR therapy', 'KRAS', 'NRAS'', 'PIK3CA', 'TP53', 'PTEN', ‘‘EGFR', 'MET', 'HER2', 'epiregulin', 'amphiregulin', 'prognostic biomarkers', 'BRAF', 'miR NA' and 'antibody-dependent cell-mediated cytotoxicity(ADCC) activity'. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and exclusion. RESULTS: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mC RCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAS mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAS-wild type colorectal cancers. So far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mR NA levels of EGFR ligands, of activating mutations in other genes such as NRAS and PIK3 CA. The prognostic value of selected micro RNAs level and ADCC activity is under investigation, while the prognostic impact of BRAF status remains controversial.CONCLUSION: This review focuses on the personalized treatment of m CRC and discusses the potential of new prognostic and predictive biomarkers in selecting patients treated with anti-EGFR therapy. | Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza Cristina Granetto Teresa Fabozzi Emanuela Miraglio Marco C Merlano | 2016 | World Journal of Gastroenterology2016，22，30： | 5 |
| 2 | Relief of pruritus and decrease in plasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergio D Emanuela C Danilo V et a1 | 1992 | N Eng J Med1992，326，1： | 1 |
| 3 | Protective effects of N-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat显示文摘 | Salvatore C Emanuela M laura D | 2001 | FASEB J2001，15，： | 1 |
| 4 | Relif ofpruritus and decrese in plasna hiatanine concentvations during erythropoietin therapy in patients with arenia显示文摘 | Serigo D Emanuela C Danilo V | 1992 | N Engl J Med1992，326，： | 1 |
| 5 | Relief of pruitus and de- crease in piasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergip D Emanuela C DaniloV | 1992 | N Engl J Med1992，326，1： | 1 |
| 6 | Proyecyive effects of N-acetylcysteine on lung injury and red blood cell modification insuced by carrageenan in the rat显示文摘 | Salvatore C Emanuela M Laura D | 2001 | FASEB J2001，15，： | 1 |
| 7 | Protective effects of N- acetycysteine on lung injury and red blood cell modification induced by carrageenan in the rat 显示文摘 | Salvatore C Emanuela M Laura D | 2001 | Paseb J2001，15，7： | 1 |
| 8 | Quantitative PCR of bone marrow BCL2/IgH cells at diagnosis predicts treatment response and long-term outcome in follicular non-Hodgkin lymphoma显示文摘 | Alessandro R Emanuela C Elena O | 2005 | Blood2005，105，9： | 1 |
| 9 | Relief of pruritus anti decrease in plasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergio D Emanuela C Danilo V | 1992 | N Engl J Med1992，326，： | 1 |
| 10 | Relief of pruritus and decrease in plasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergio D Emanuela C Danilo V | 1992 | N Engl J Med1992，326，： | 1 |
| 11 | Relief of pruritus and decrease inplasma histamine concentrations during erythropoietin therapy in patientswith uremia显示文摘 | Sergio D Emanuela C Danilo V | 1992 | JMed1992，326，： | 1 |
| 12 | Relief of Pruritu and Decrease in Plasma Histamine Comcertrations during Ery 2 Thropoietin Therapy in Patients with Uremia显示文摘 | Sergio D Emanuela C Danilo V | 1992 | N Engl J Med1992，326，15： | 1 |
| 13 | 显示文摘 | Licciardi M Emanuela F C Giammona G | 2008 | Macromol Biosci2008，8，10： | 1 |
| 14 | Relief of pruritus and decrease in plasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergio D Emanuela C Danilo V et la | 1992 | N Eng J Med1992，326，1： | 1 |
| 15 | Relief of pruritus and decrease inplasma histamine concentrations during erythropoietin therapy in patientswith uremia 显示文摘 | Sergio D Emanuela C Danilo V | 1992 | J Med1992，326，： | 1 |
| 16 | Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates显示文摘 | Raffaele C Nicoletta V Emanuela B | 1994 | Antivir ResVolume Issue1994，23，1： | 1 |
| 17 | Recruitment of circulating allergen-specific T lymphocytes to the lung on allergen challenge in asthma显示文摘 | Barbara B Giulia C Emanuela | 1997 | J Allergy Clin Immun1997，100，： | 1 |
| 18 | Protective effects of n-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat 显示文摘 | Salvatore C Emanuela M Laura D | 2001 | The FASEB Journal2001，15，： | 1 |
| 19 | Influence of severe plastic deformation on aging of AI-Mg-Si alloys显示文摘 | Emanuela C Paola L | 2005 | Materials Science and Engineering A2005，，： | 1 |
| 20 | Relief of pruritus and decrease in plasma histamine concentrations during erythropoietin therapy in patients with uremia显示文摘 | Sergio D Emanuela C Danilo V | 1992 | N Engl J Med1992，326，15： | 1 |
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