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| 1 | Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts显示文摘The reclamation and disinfection of waters impacted by human activities(e.g., wastewater effluent discharges) are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts(N-DBPs). Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-DBPs. Individual toxicity assays have been performed on many DBPs, but few studies have been conducted with complex mixtures such as wastewater effluents. In this work, we compared the cytotoxicity and genotoxicity of wastewater effluent organic matter(Ef OM) before and after chloramination. The toxicity of chloraminated Ef OM was significantly higher than the toxicity of raw Ef OM, and the more hydrophobic fraction(HPO)isolated on XAD-8 resin was more toxic than the fraction isolated on XAD-4 resin.More DBPs were also isolated on the XAD-8 resin. N-DBPs(i.e., haloacetonitriles or haloacetamides) were responsible for the majority of the cytotoxicity estimated from DBP concentrations measured in the XAD-8 and XAD-4 fractions(99.4% and 78.5%, respectively).Measured DBPs accounted for minor proportions of total brominated and chlorinated products, which means that many unknown halogenated compounds were formed and can be responsible for a significant part of the toxicity. Other non-halogenated byproducts(e.g.,nitrosamines) may contribute to the toxicity of chloraminated effluents as well. | Julien Le Roux Michael J.Plewa Elizabeth D.Wagner Maolida Nihemaiti Azra Dad Jean-Philippe Croué | 2017 | Journal of Environmental Sciences2017，29，8： | 8 |
| 2 | 双嘧达莫负荷超声心动图探测冠状动脉狭窄的病理生理基础显示文摘目的 探讨双嘧达莫负荷超声评价冠状动脉狭窄的病理生理基础。方法 双嘧达莫负荷超声评价慢性冠脉狭窄犬的室壁增厚率 (%WT) ,放射性微球定量心肌血流量 (MBF)。结果 负荷状态 ,MBF储备 <2的心肌节段 %WT减小 ;2≤MBF储备 <3的节段 %WT无明显变化 ;而MBF储备≥ 3的节段 %WT反而增加。 | 宾建平 Elizabeth Le Robert A Pelberg 刘伊丽 查道刚 Sanjiv Kaul | 2001 | 中国医学影像技术2001，17，2： | 3 |
| 3 | Rapid and flexible segmentation of electron microscopy data using few-shot machine learning显示文摘Automatic segmentation of key microstructural features in atomic-scale electron microscope images is critical to improved understanding of structure–property relationships in many important materials and chemical systems.However,the present paradigm involves time-intensive manual analysis that is inherently biased,error-prone,and unable to accommodate the large volumes of data produced by modern instrumentation.While more automated approaches have been proposed,many are not robust to a high variety of data,and do not generalize well to diverse microstructural features and material systems.Here,we present a flexible,semi-supervised few-shot machine learning approach for segmentation of scanning transmission electron microscopy images of three oxide material systems:(1)epitaxial heterostructures of SrTiO_(3)/Ge,(2)La_(0.8)Sr_(0.2)FeO_(3) thin films,and(3)MoO_(3) nanoparticles.We demonstrate that the few-shot learning method is more robust against noise,more reconfigurable,and requires less data than conventional image analysis methods.This approach can enable rapid image classification and microstructural feature mapping needed for emerging high-throughput characterization and autonomous microscope platforms. | Sarah Akers Elizabeth Kautz Andrea Trevino-Gavito Matthew Olszta Bethany E.Matthews Le Wang Yingge Du Steven R.Spurgeon | 2021 | npj Computational Materials2021，，1： | 3 |
| 4 | Cell:癌基因“遗传平衡”或会影响患者对癌症疗法的反应显示文摘进行癌症疗法的选择越来越需要确定肿瘤细胞中是否含有一些特殊突变的癌基因会驱动癌细胞异常生长。并且确定是否癌细胞会对特殊药物耐受或敏感.近日来自加州大学旧金山分校的研究人员就通过研究发现。以常见的癌基因KRAs突变为例。患者对疗法的反应往往会随着肿瘤的不断进化而发生改变。相关研究刊登于国际杂志Cell上。 | Michael R. Burgess Eugene Hwang Rana Mroue Craig M. Bielski Anica M. Wandler Benjamin J. Huang Ari J. Firestone Amy Young Jennifer A. Lacap Lisa Crocker Saurabh Asthana Elizabeth M. Davis Jin Xu Keiko Akagi Michelle M. Le Beau Qing Li Benjamin Haley David Stokoe Deepak Sampath Barry S. Taylor Marie Evangelista Kevin Shannon | 2017 | 现代生物医学进展2017，17，18： | 2 |
| 5 | Quantification of renal blood flow with contrast-enhanced ultrasound显示文摘 | Kevin Wei Elizabeth Le Jian-Ping Bin Matthew Coggins Jerrel Thorpe Sanjiv Kaul | 2001 | Journal of the American College of Cardiology2001，，： | 2 |
| 6 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 7 | In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate显示文摘 | Ervin Pejo Joseph F. Cotten Elizabeth W. Kelly Ri Le Ge Gregory D. Cuny Joydev K. Laha Jifeng Liu Xiang Jie Lin Douglas E. Raines | 2012 | Anesthesia & Analgesia2012，，： | 2 |
| 8 | 多巴酚丁胺和腺苷对心肌血流速度和容积的影响及其评价冠脉狭窄的意义显示文摘目的 评价多巴酚丁胺和腺苷对冠脉微循环的直接效应。方法 建立 8条一支冠脉 (左前降支或左回旋支 )轻中度狭窄的犬模型 ,直接冠脉内输注多巴酚丁胺和腺苷。采用经外周静脉微泡连续输注法 ,在谐波和递增性间断超声发射下进行心肌声学造影 (MCE) ,测定微泡速度 (MV)和心肌血流容积 (MBV )。以放射性微球测定心肌血流量 (MBF)。结果 在正常冠脉供血区中 ,虽然两种药物引起MBF明显增加 [静息时 ( 1.1± 0 .4)ml/(min·g) ;输注多巴酚丁胺和腺苷时分别为 ( 3 .7± 1.2 )ml/(min·g)和 ( 4 .7± 1.0 )ml/(min·g) ] ,而MBV仅轻微增加 (分别为 13 % ,17% ) ,但是MV增加的程度与MBF相一致 (静息时 5 .0± 0 .9;多巴酚丁胺和腺苷分别为12 .3± 4.1,13 .8± 4.1)。在狭窄冠脉供血区中 ,虽然两种药物引起了一定程度的MBF增加 (P <0 .0 5 ) ,但MBV较静息状态降低 (P <0 .0 5 ) ;然而MV明显高于静息状态 (P <0 .0 5 ) ,两种药物间比较无差异。两种药物负荷时的MV比值 (狭窄 /正常 )与MBF比值之间有良好的线性相关 (P <0 .0 0 5 ,r分别为 0 .85和 0 .68)。结论 冠脉内直接输注多巴酚丁胺和腺苷时 ,两种药物对狭窄和正常冠脉供血区微循环的影响相似。因此 ,两种药物可在冠脉狭窄的评价中交互使用。 | 宾建平 Kevin Wei Elizabeth Le Matthew Coggins 刘伊丽 Sanjiv Kaul | 2000 | 中华超声影像学杂志2000，9，4： | 2 |
| 9 | Cloud service selection: State-of-the-art and future research directions显示文摘 | Le Sun Hai Dong Farookh Khadeer Hussain Omar Khadeer Hussain Elizabeth Chang | 2014 | Journal of Network and Computer Applications2014，，： | 1 |
| 10 | Analysis of fiducials implanted during EUS for patients with localized rectal cancer receiving high-dose rate endorectal brachytherapy显示文摘 | Shalini Moningi Amanda J. Walker Ashkan A. Malayeri Lauren M. Rosati Susan Gearhart Jonathan Efron Elizabeth Wick Nilofer Azad Elwood P. Armour Yi Le Joseph M. Herman Eun Ji Shin | 2014 | Gastrointestinal Endoscopy2014，，： | 1 |
| 11 | Amphipathic helices from aromatic amino acid oligomcrs ASAP显示文摘 | Elizabeth R Gillies Christel Dolain Jean-Michel Le' ger | 2006 | J Org Chem2006，71，： | 1 |
| 12 | Viability and stability of biological control Agents on cotton and snap bean seeds显示文摘 | Monica LE Elizabeth ADJ William EBJ | 2001 | Pest Manag Sci2001，57，： | 1 |
| 13 | Perfusion Versus Function: The Ischemic Cascade in Demand Ischemia: Implications of Single-Vessel Versus Multivessel Stenosis显示文摘 | Howard Leong-Poi Se-Joong Rim D. Elizabeth Le Nick G. Fisher Kevin Wei Sanjiv Kaul | 2002 | Circulation: Journal of the American Heart Association2002，，： | 1 |
| 14 | Viability and stability of biological control agents on cotton and snap bean seeds显示文摘 | Plant-Microbe Interactions Monica LE Elizabeth ADJ William EBJ | 2001 | Pest Management Science2001，57，69： | 1 |
| 15 | Detection of Noncritical Coronary Stenosis at Rest Without Recourse to Exercise or Pharmacological Stress显示文摘 | Kevin Wei Elizabeth Le Ananda R. Jayaweera Jian-Ping Bin N. Craig Goodman Sanjiv Kaul | 2002 | Circulation: Journal of the American Heart Association2002，，2： | 1 |
| 16 | 心肌对比超声评价多巴酚丁胺对冠状动脉微循环的直接效应:与腺苷对比显示文摘目的评价多巴酚丁胺对正常和狭窄冠状动脉微循环的直接效应,并与腺苷对比。方法实验应用9条健康杂种犬,制备左前降支静息无血流限制性狭窄。在静息状态和左冠状动脉主干内连续输注多巴酚丁胺(2mg·kg^-1·min^-1)和腺苷(5mg·kg^-1·min^-1)时,进行间断谐波心肌对比成像评估心肌血流容积(A)和心肌血流速度(b),并同步应用放射性标记微球测定心肌血流量(MBF),计算心率血压乘积和心肌血管阻力(MVR)。结果两种药物引起正常和狭窄冠状动脉供血区MBF明显增加和MVR明显降低(P<0.05)。在正常冠状动脉供血区,腺苷对A无明显影响,MVR的降低完全是阻力血管的扩张所致(99%),MBF增加主要是由于b的加快(△β/△A=13.6);多巴酚丁胺可引起部分A增加(28%),使总MVR降低中的32%来自这种毛细血管征募,但MBF增加主要还是由于b的加快(△β/△A=5.9)。在狭窄冠状动脉供血区,两种药物引起MBF增加的程度相同,MBF增加均完全是由于b的加快;多巴酚丁胺和腺苷引起毛细血管的关闭分别导致14%和15%心肌毛细血管阻力的增加。结论经冠状动脉内直接给药物时,多巴酚丁胺对冠状动脉微循环的直接效应与腺苷对冠状动脉微循环的直接效应非常相近,MBF增加主要由于心肌血流速度的增快所致。 | 宾建平 D. Elizabeth Le 杨帆 查道刚 刘伊丽 Sanjiv Kaul | 2008 | 南方医科大学学报2008，28，3： | 1 |
| 17 | Re-visiting the competence/performance debate in the acquisition of the counting principles显示文摘 | Mathieu Le Corre Gretchen Van de Walle Elizabeth M. Brannon Susan Carey | 2005 | Cognitive Psychology2005，，2： | 1 |
| 18 | Re-visiting the competence/performance debate in the acquisition of the counting principles显示文摘 | Mathieu Le Corre Gretchen Van de Walle Elizabeth M. Brannon Susan Carey | 2005 | Cognitive Psychology2005，，2： | 1 |
| 19 | A key role for PTP1B in dendritic cell maturation, migration, and T cell activation显示文摘Dendritic cells(DC)are the major antigen-presenting cells bridging innate and adaptive immunity,a function they perform by converting quiescent DC to active,mature DC with the capacity to activate naı¨ve T cells.They do this by migrating from the tissues to the T cell area of the secondary lymphoid tissues.Here,wedemonstrate thatmyeloid cell-specific genetic deletion of PTP1B(LysM PTP1B)leads to defects in lipopolysaccharide-driven bone marrow-derivedDC(BMDC)activation associated with increased levels of phosphorylated Stat3.We showthatmyeloid cell-specific PTP1Bdeletion also causes decreased migratory capacity of epidermal DC,aswell as reduced CCR7 expression and chemotaxis to CCL19 by BMDC.PTP1B deficiency in BMDC also impairs their migration in vivo.Further,immature LysM PTP1B BMDC display fewer podosomes,increased levels of phosphorylated Src at tyrosine 527,and loss of Src localization to podosome puncta.In co-culture with T cells,LysM PTP1B BMDC establish fewer and shorter contacts than control BMDC.Finally,LysMPTP1BBMDCfail to present antigen to T cells as efficiently as controlBMDC.These data provide first evidence for a key regulatory role for PTP1B in mediating a central DC function of initiating adaptive immune responses in response to innate immune cell activation. | Cristina Martin-Granados Alan R.Prescott Samantha Le Sommer Izabela P.Klaska Tian Yu Elizabeth Muckersie Claudiu V.Giuraniuc Louise Grant Mirela Delibegovic John V.Forrester | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 20 | Comparison of the effects of anticonvulsant drugs with diverse mechanisms of action in the formalin test in rats显示文摘 | Harlan ES Elizabeth LE Steven C | 2005 | Neuropharmacology2005，48，： | 1 |
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