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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Effects of sheet flow rate and slope gradient on sediment load显示文摘 | Elham S Majid M | 2014 | Arabian Journal of Geosciences2014，7，1： | 1 |
| 3 | Synthesis of new microbial pesticide metal complexes derived from cou- marin-imine ligand 显示文摘 | Amel F E Elham S A Huda M A | 2014 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2014，128，： | 1 |
| 4 | Orthodontic treatment need and demand in 12-14-year-old north Jordanian school children显示文摘 | Elham S J Abu Alhaija Kazem S | 2004 | Eur J Orthod2004，26，3： | 1 |
| 5 | Nano-level de- termination of copper with atomic absorption spec- trometry after pre-concentration on N, N-(4-methyl-1, 2-phenylene ) diquinoline-2-carboxamide-naphthalene 显示文摘 | BEHZAD R ELHAM S SORAIA M | 2009 | Journal of Hazardous Materials2009，168，23： | 1 |
| 6 | Alkali treated Foumanat tea waste as an efficient adsorbent form ethylene blue adsorption from aqueous solution显示文摘 | Azadeh E P Elham S Moslem B | 2014 | Water Resources and Industry2014，6，： | 1 |
| 7 | Microfihration of oily wastewater using PP hydrophobic membrane 显示文摘 | Elham G Mohtada S Mohammadi T | 2006 | Desalination2006，200，13： | 1 |
| 8 | Synthesis, crystal structure and catalytic activity of a new Mo Schiff base complex with Mo histidine immobilized on A1-MCM-41 for oxidation of sulfides 显示文摘 | ELHAM Z FAEZEH F JIM S | 2014 | lnorganiea Chimica Acta2014，414，： | 1 |
| 9 | Silica supported Fe(HSO4)3as an efficient,heterogeneous and recyclable catalystfor synthesis ofβ-enaminones andβ-enamino esters显示文摘 | HOSSEIN E SEYED M ELHAM S | 2012 | Journal of Molecular Catalysis A:Chemical2012，363，： | 1 |
| 10 | Effect of heating,UVirradiation and pH on stability o f the anthocyanin copig-ment complex显示文摘 | Parisa S Reza H Elham G | 2007 | Pakistan Journal of Biological Sci-ences2007，10，2： | 1 |
| 11 | Interleukin-6gene polymorphism in Iranian patients with systemic lupus erythematosus显示文摘 | ESMAEIL M G ESKANDAR K S ELHAM A | 2011 | Clin Rheuma-tol2011，30，： | 1 |
| 12 | A simple and efficient multi -residue method based on QuEChERS for pesticides deter- mination in palm oil by liquid chromatography time - of - flightmass spectrometry 显示文摘 | Elham S Nor KA Keivan N | 2012 | Journal of Environmental Mo- nitoring and Assessment2012，184，9： | 1 |
| 13 | Modeling and short cir- cuit detection of 18650 Li-ion cells under mechanical a buse conditions显示文摘 | Elham S John C Tomasz W | 2012 | Jouranl of Power Sources2012，220，： | 1 |
| 14 | Effects of harmonic sources on customer loads 显示文摘 | ELHAM B M LYNNA S SRINIVAS V | | Electric Power System Research 199 40，29，1： | 1 |
| 15 | Droplet impact dynamics on a spherical particle显示文摘 | SUBHASISH M MAYUR J S ELHAM D | 2013 | Chemical Engineering Science2013，，100： | 1 |
| 16 | Low temperature followed by matrix solid-phase dispersion-sonieatiou procedure for the determination of muhiclass pesticides in palmoil using LC-TOF- MS显示文摘 | Elham S NorKartini B Radzi M | 2011 | Journal of Hazardous Materials2011，186，23： | 1 |
| 17 | Shotgun proteomic analysis of long-distance drought signaling in rice roots显示文摘 | Mehdi M Neda S Elham S | 2011 | Journal of Proteome Research2011，11，1： | 1 |
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