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| 1 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 2 | Outcomes of Parent-Child Interaction Therapy : A Comparison of Treatment Completers and Study Dropouts One to Three Years Later 显示文摘 | Boggs Stephen R Eybert Sheila M Edwards Daniel L | 2005 | Child and Family Behavior Therapy2005，26，4： | 1 |
| 3 | Poultry litter and manure contributions to nitrate leaching through the vadose zone显示文摘 | Adams P L Daniel T C Edwards D R | 1994 | Soil Science Society of America Journal1994，58，： | 1 |
| 4 | Axial Magnetic Bearing Development for the BiVACOR Rotary Bi-VAD/TAH 显示文摘 | Nicholas A Greatrex Daniel L Timms Edward W Palmer | 2010 | IEEE Transactions on Biomedical Engineering2010，57，3： | 1 |
| 5 | Poultry litter and manure contributions to nitrate eaching through the vadose zone显示文摘 | Adams P L Daniel T C Edwards D R | 1994 | Soil Science Society of American Journal1994，58，4： | 1 |
| 6 | Poultry Litter and Manure Contributions to Nitrate Leaching Through the Vadose Zone显示文摘 | ADAMS P L DANIEL T C EDWARDS D R | | 0，，4： | 1 |
| 7 | Poultry Litter and Manure Contributions to Nitrate Leaching Through the Vadose Zone 显示文摘 | Adams P L Daniel T C Edwards D R | 1994 | Soil Science Society of America Journal1994，58，4： | 1 |
| 8 | Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice显示文摘 | Christopher L Bradley C G Francine S F Carolyn A W David E O Bernhard J H Zhifeng L Edward O Bruce E T Daniel R S | 2000 | Nature2000，407，： | 1 |
| 9 | Estimating root respiration, microbial respiration in the rhizosphere, and root-free soil respiration in forest soils显示文摘 | Daniel L Kelting James A Burger Gerry S Edwards | 1997 | Soil Biology and Biochemistry1997，，7： | 1 |
| 10 | Estimating root respiration,microbial respiration in the rhizosphere,and root-free soil respiration in forest soils显示文摘 | Daniel L K Burger J A Edwards G S | | 0，，07： | 1 |
| 11 | Bactericial mode of titanium dioxide photocatalysis显示文摘 | Zheng Huang Pin-Ching Maness Daniel M Blake Edward J Wolfrum Sharon L Smolinski William A Jaeoby | 2000 | Journal of Photochemistry and Photobiology A : Chemistry2000，130，： | 1 |
| 12 | 小肠良性肿瘤: 地点 isnt 一切!显示文摘 AIM: To investigate the prognostic significance of the primary site of disease for small bowel carcinoid(SBC) using a population-based analysis.METHODS: The Surveillance,Epidemiology and End Results(SEER) database was queried for histologically confirmed SBC between the years 1988 and 2009.Overall survival(OS) and disease-specific survival(DSS) were analyzed using the Kaplan-Meier method and compared using Log rank testing.Log rank and multivariate Cox regression analyses were used to identify predictors of survival using age,year of diagnosis,race,gender,tumor histology/size/location,tumor-node-metastasis stage,number of lymph nodes(LNs) examined and percent of LNs with metastases.RESULTS: Of the 3763 patients,51.2% were male with a mean age of 62.13 years.Median follow-up was 50 mo.The 10-year OS and DSS for duodenal primaries were significantly better when compared to jejunal and ileal primaries(P = 0.02 and < 0.0001,respectively).On multivariate Cox regression analysis,after adjusting for multiple factors,primary site location was not a significant predictor of survival(P = 0.752 for OS and P = 0.966 DSS) while age,number of primaries,number of LNs examined,T-stage and M-stage were independent predictors of survival.CONCLUSION: This 21-year,population-based study of SBC challenges the concept that location of the primary lesion alone is a significant predictor of survival. | Danielle M Hari Stephanie L Goff Heidi J Reich Anna M Leung Myung-Shin Sim Ji Hey Lee Edward Wolin Farin Amersi | 2013 | World Journal of Gastrointestinal Surgery2013，5，8： | 1 |
| 13 | Cardiovascular complication of cancer therapy显示文摘 | Edward T H Y Ann T T Daniel J L | | 0，，： | 1 |
| 14 | Use of grass filter strips to reduce 17β-estrdiol in runoff from fescue-applied poultry litter显示文摘 | NICHOLS D J DANIEL L C EDWARDS D R | 1998 | Journal of Soil and Water Conservation1998，53，1： | 1 |
| 15 | Poultry litter and manure contributions to nitrate leaching through the vadose zone显示文摘 | Adams P L Daniel T C Edwards D R | 1994 | Soil Science Society of America Journal1994，58，： | 1 |
| 16 | Poultry litter and manure contributions to nitrate leaching through the vadose zone显示文摘 | ADAMS P L DANIEL T C EDWARDS D R | 1994 | Soil Science Society of America Journal1994，58，4： | 1 |
| 17 | Benzospirans Bearing Basic Substitution Ⅱ:Amines Derived from 3',4'-dihydrospiro Cyclohexane-1,1'(2'H)-naphthalen-4-one显示文摘 | DANIEL L D EDWARD E | 1975 | J Org Chem1975，40，26： | 1 |
| 18 | Probability of prostate cancer detection based on results of a multicenter study using the AxSYM free PSA and total PSA assays显示文摘 | Robert L Vessella Paul H Lange Alan W Partin Daniel W Chan Lori J Sokoll Edward A Sasse E.David Crawford | 2000 | Urology2000，，6： | 1 |
| 19 | A tabletop X-ray tomography instrument for nanometer-scale imaging: reconstructions显示文摘We show three-dimensional reconstructions of a region of an integrated circuit from a 130 nm copper process.The reconstructions employ x-ray computed tomography,measured with a new and innovative high-magnification x-ray microscope.The instrument uses a focused electron beam to generate x-rays in a 100 nm spot and energy-resolving x-ray detectors that minimize backgrounds and hold promise for the identification of materials within the sample.The x-ray generation target,a layer of platinum,is fabricated on the circuit wafer itself.A region of interest is imaged from a limited range of angles and without physically removing the region from the larger circuit.The reconstruction is consistent with the circuit's design file. | Zachary H.Levine Bradley K.Alpert Amber L Dagel Joseph W.Fowler Edward S.Jimenez Nathan Nakamura Daniel S.Swetz Paul Szypyt Kyle R.Thompson Joel N.Ulom | 2023 | Microsystems & Nanoengineering2023，9，2： | 0 |
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