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| 1 | Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation显示文摘Mesenchymal stem cell(MSC)-based treatments have shown promise for improving tendon healing and repair.MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK,actin and myosin(two other components of the pathway) using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds. | Edward Maharam Miguel Yaport Nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun | 2015 | Bone Research2015，3，3： | 4 |
| 2 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 3 | Factors Predicting Progression to Severe COVID-19: A Competing Risk Survival Analysis of 1753 Patients in Community Isolation in Wuhan, China显示文摘Most studies of coronavirus disease 2019(COVID-19)progression have focused on the transfer of patients within secondary or tertiary care hospitals from regular wards to intensive care units.Little is known about the risk factors predicting the progression to severe COVID-19 among patients in community iso-lation,who are either asymptomatic or suffer from only mild to moderate symptoms.Using a multivari-able competing risk survival analysis,we identify several important predictors of progression to severe COVID-19—rather than to recovery—among patients in the largest community isolation center in Wuhan,China from 6 February 2020(when the center opened)to 9 March 2020(when it closed).All patients in community isolation in Wuhan were either asymptomatic or suffered from mild to moderate COVID-19 symptoms.We performed competing risk survival analysis on time-to-event data from a cohort study of all COVID-19 patients(n=1753)in the isolation center.The potential predictors we inves-tigated were the routine patient data collected upon admission to the isolation center:age,sex,respira-tory symptoms,gastrointestinal symptoms,general symptoms,and computed tomography(CT)scan signs.The main outcomes were time to severe COVID-19 or recovery.The factors predicting progression to severe COVID-19 were:male sex(hazard ratio(HR)=1.29,95%confidence interval(CI)1.04–1.58,p=0.018),young and old age,dyspnea(HR=1.58,95%CI 1.24–2.01,p<0.001),and CT signs of ground-glass opacity(HR=1.39,95%CI 1.04–1.86,p=0.024)and infiltrating shadows(HR=1.84,95%CI 1.22–2.78,p=0.004).The risk of progression was found to be lower among patients with nausea or vomiting(HR=0.53,95%CI 0.30–0.96,p=0.036)and headaches(HR=0.54,95%CI 0.29–0.99,p=0.046).Our results suggest that several factors that can be easily measured even in resource-poor set-tings(dyspnea,sex,and age)can be used to identify mild COVID-19 patients who are at increased risk of disease progression.Looking for CT signs of ground-glass opacity and infiltrating shadows may be an affordable option to support triage decisions in resource-rich settings.Common and unspecific symptoms(headaches,nausea,and vomiting)are likely to have led to the identification and subsequent community isolation of COVID-19 patients who were relatively unlikely to deteriorate.Future public health and clinical guidelines should build on this evidence to improve the screening,triage,and monitoring of COVID-19 patients who are asymtomatic or suffer from mild to moderate symptoms. | Simiao Chen Hui Sun Mei Heng Xunliang Tong Pascal Geldsetzer Zhuoran Wang Peixin Wu Juntao Yang Yu Hu Chen Wang Till Bärnighausen | 2022 | Engineering2022，8，6： | 1 |
| 4 | Dopaminergic trophism after intrastriatal injection of lentivirus-transferred GDNF in Parkinson rat model显示文摘 | Sun B Hui GZ Guo LH | 2003 | Shengwuhuaxue Yushengwuwulixuebao(Shanghai)2003，35，10： | 1 |
| 5 | 显示文摘 | Sun Y Wang B Hui C | 2006 | J Macromol Sci Phys2006，45，： | 1 |
| 6 | Synthesis and characterization of magnetic polymer microspheres显示文摘 | SUN Y WANG B HUI C | 2006 | J Macromol Sci Phys2006，45，： | 1 |
| 7 | Chronic cocaine-induced H3 acetylation and transcriptional activation of Ca MKⅡalpha in the nucleus accumbens is critical for motivation for drug reinforcement显示文摘 | Wang L Lv Z Hu Z Sheng J Hui B Sun J | 2010 | Neuropsychopharmacology2010，35，4： | 1 |
| 8 | Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis显示文摘 | Zhang Weili Sun Kai Yang Ying Zhang Hongye Hu Frank B Hui Rutai | 2009 | Clinical Chemistry2009，，： | 1 |
| 9 | Dopaminergic trophism after intrastriatal injection of lentivirus-transferred GDNF in Parkinson rat model显示文摘 | Hui GZ Guo LH | 2003 | Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao2003，35，： | 1 |
| 10 | Detection of optical neuronal signals in the visual cortex using continuous wave near infrared spectroscopy显示文摘 | Sun B Lei Z Hui G | 2014 | Neuroimage2014，87，2： | 1 |
| 11 | Differential requirement s for VirB1 and VirB2 during Brueella abortus infection显示文摘 | Andreas B Den Hartigh Yao- Hui Sun | 2004 | Infect Immun2004，72，9： | 1 |
| 12 | Dopaminergic Trophism after Intrastriatal Injection of Lentivirus-transferred GDNF in Parkinson Rat Model显示文摘 | Sun B Hui GZ Guo LH | 2003 | Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao2003，35，10： | 1 |
| 13 | A Cross-cultural Examination of the Noise-sensitivity Scale-short Form:Measurement Invariance Testing between the US and Chinese Samples显示文摘Unwanted sound that is unpleasant or disruptive to hear,often interpreted as noise,is a widespread environmental pollutant.Similar to other environmental pollutants,this noise incurs a variety of costs to society.Numerous negative health impacts are linked to increases in noise exposure, such as increased cardiovascular risk[1]and sleep disturbance[2].Research suggests that noise impacts cognitive processes[3],mood states[4],and recreational experiences[5].Collectively,this body of research demonstrates that noise interferes with human health and well-being. | Zachary D Miller HUANG Jun Wu Heather Costigan LUO Jing DENG Hui Juan XU Xiao Qing B Derrick Taff SUN Cheng YANG Xi WANG Zhong Lei LIN Dan QU Shu Wen PAN Bing LI Guang Ming Peter Newman | 2018 | Biomedical and Environmental Sciences2018，31，11： | 0 |
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