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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 3 | I- conotoxins in vermivorous species of the West Atlantic:peptide sr11a from Conus spurious显示文摘 | AGUILAR M B ESTUARDO L V EDGAR P H | 2007 | Peptides2007，28，1： | 1 |
| 4 | Optimizing the use of detector arrays for measuring intensity correlations of photon pairs显示文摘 | Tasca D S Edgar M P Izdebski F | 2013 | Physical Review A2013，88，13： | 1 |
| 5 | NCBI GEO: mining tens of millions of expression profiles - - database and tools update 显示文摘 | Barrett T Troup DB Wilhite SE Ledoux P Rudnev D Evangelista C Kim IF Soboleva A Tomashevsky M Edgar R | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 6 | 3D computational imaging with single-pixel detectors 显示文摘 | Sun B Edgar M P Bowman R | 2013 | Science2013，340，： | 1 |
| 7 | Conversion of coal fly ashes into fauiasite under soft temper ature and pressure conditions: Influence of additional silica 显示文摘 | Marion G Michel S Philippe C Joel P Edgar M Isabelle S | 2010 | Microporous and Mesoporous Materials2010，127，12： | 1 |
| 8 | Multi-wave-length Compressive Computational Ghost Imaging显示文摘 | WELSH S S EDGAR M P JONATHAN P | 2013 | SPIE2013，8618，86： | 1 |
| 9 | Ph{rsphorylation of the cabin kinase 2 domain of B-50 ( GAP-43 ) in rat cortical growth cones显示文摘 | Edgar MA Pisanelli P DeWit M | 1997 | J Neurohem1997，69，5： | 1 |
| 10 | Simultaneous real time visible and infrared video with single-pixel detectors显示文摘 | Edgar M P Gibson G M Bowman R W | 2015 | Scientific Reports2015，5，： | 1 |
| 11 | Molecular characterization by AFLP of Capsicum germplasm from the Amazon department colombia,characterization by AFLP of Capsicum显示文摘 | SANDRA P T FERNANDO R EDGAR M MYRIAM C D JOE T | 2003 | Genetic Resources and Crop Evolution2003，50，8： | 1 |
| 12 | The biogeochemistry of polychlorinated biphenyls (PCBs) in the Clyde: distribution and source evaluation显示文摘 | Edgar P J Davies I M Hursthouse A S | 1999 | Marine Pollution Bulletin1999，38，6： | 1 |
| 13 | 3D computational imaging with single-pixel detectors 显示文摘 | Sun B Edgar M P Bowman R | 2013 | Science2013，340，6134： | 1 |
| 14 | Salivary α-synuclein and DJ-1:potential biomarkers for Parkinson's disease显示文摘 | Devic I Hwang H Edgar J S Izutsu K Presland R Pan C Goodlett D R Wang Y Armaly J Tumas V Zabetian C P Leverenz J B Shi M Zhang J | | 0，，07： | 1 |
| 15 | The Highly Diastereoselective Synthesis of Oxazolidines Derived from Ketones and Pseudoephedrine or Ephedrine显示文摘 | Buckley B R Page P C B Edgar M | 2005 | Synlett2005，36，6： | 1 |
| 16 | Methyl-jasmonate induced gene ex- pression in wheat delays symptom development by the crown rot pathogen Fusarium pseudograminearum显示文摘 | DESMOND O J EDGAR C I MANERS J M MACLEAN D J SCHENK P M KAZAN K | 2006 | Physiological and Mo- lecular Plant Pathology2006，67，： | 1 |
| 17 | Quantification of dental plaque in the research environment显示文摘 | Pretty I A Edgar W M Smith P W | 2005 | J of Dentistry2005，33，： | 1 |
| 18 | Plasma membrane H^+-ATPase is involved in auxin-mediated cell elongation during wheat embryo development显示文摘 | NICOLE R K JOLANA T P A SONJA F NORBERT H WOLFGANG M EDGAR W VOLKER S GUNTHER N CHRISTIANE F I | 2003 | Plant Physiol2003，131，3： | 1 |
| 19 | Molecular characterization by AFLPs of Capsicum germplasm from the Amazon Department in Colombia,characterization by AFLPs of Capsicum显示文摘 | SANDRA P T FERNANDO R EDGAR M MYRIAM C D JOE T | 2003 | Genetic Resources and Crop Evolution2003，50，： | 1 |
| 20 | D Computational Imaging with Single-Pixel Detectors显示文摘 | SUN B EDGAR M P BOWMAN R | 2013 | Science2013，340，6134： | 1 |
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