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| 1 | Increased proliferation activity measured by immunoreactive Ki67 is associated with survival improvement in rectal/recto sigmoid cancer显示文摘AIM: To assess the expression of Ki67 as prognosticator in rectal/recto sigmoid cancer.METHODS: Samples from 146 patients with rectal and recto sigmoid cancer were studied for expression of Ki67 and its prognostic significance in comparison with clinicopathological predictors of survival. Formalin-fixed, paraffin-embedded tissues from 6 (4.1%) patients with T1, 26 (17.8%) with T2, 94 (64.4%) with T3, and 20 (13.7%) with T4 tumors were studied. Ki67 expression was determined immunohistochemically. Samples were divided according to mean value into high (>40%) and low (≤40%) expression. Areas of extensive proliferation (>50%) were defined as 'hot spot' areas. RESULTS: Hot spot areas were present in samples regardless of histopathological grade. Lower TNM and Dukes stage and higher expression of Ki67 and presence of Ki67 hot spot areas in histopathological samples were associated with better survival, whereas no association was observed with histopathological grade (P = 0.78). In Cox multivariate regression analysis, significant prognostic factors were Dukes stage (P<0.001), presence of lymph node metastases (P = 0.015), age (P = 0.035) andpresence of Ki67 hot spot areas (P = 0.044). CONCLUSION: Proliferative activity as measured by Ki67 in rectal cancer is associated with survival improvement compared with patients with low Ki67. Areas of prognostically significant increased proliferation were found independently of histopathological tumor grade. | Eeva Salminen Salla Palmu Tero Vahlberg Peter J.Roberts Karl-Owe S(o|¨)derstr(o|¨)m | 2005 | World Journal of Gastroenterology2005，11，21： | 15 |
| 2 | 8q24amplification intransitional cell carcinoma of bladder显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 3 | Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme显示文摘 | ZHOU H MIKI R EEVA M | | 0，，08： | 1 |
| 4 | 8q24 amplification intransi- tional cell carcinoma ofbladder 显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl lmmunohistochem Mol Morpho2003，11，1： | 1 |
| 5 | 8q24 amplification in transitional cell carcinoma of bladder显示文摘 | Visapaa H Seligson D Eeva M | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 6 | 8q24 amplification in transitional cell carcinoma of bladder显示文摘 | VISAPAA H SELIGSON D EEVA M | 2003 | Appl Immunohistochem Mol Morphol2003，11，1： | 1 |
| 7 | Regulation of nitric oxide production in osteoarthritic and rheumatoid cartilage Role of endogenous IL‐1 inhibitors显示文摘 | Katriina Vuolteenaho Teemu Moilanen Mari H?m?l?inen Eeva Moilanen | 2003 | Scandinavian Journal of Rheumatology2003，，1： | 1 |
| 8 | Nonsteroidal anti-inflammatory drugs,cyclooxygenase-2 and the bone healing process显示文摘 | Katriina V Teemu M Eeva M | 2007 | Basic and Clin Pharmacology-&Toxicology2007，102，1： | 1 |
| 9 | Computer-assisted, high- performance liquid chromatography with mass spectrometric detec- tion for the analysis of coumarins in Peucedanum palustre and An- gelica archangelica显示文摘 | Eeva M Rauha J P Vuorela P | 2004 | Phytochem Anal2004，15，： | 1 |
| 10 | Reciprocal regulation of SOCS 1and SOCS3 enhances resistance to ionizing radiation in glioblastomamultiforme显示文摘 | Zhou H Miki R Eeva M | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 11 | Calcineurin inhibitors,cyclosporine A and tacrolimus inhibit expression of inducible nitric oxide synthase in colon epithelial and macrophage cell lines显示文摘 | Mari H Aleksi L Eeva M | 2002 | Eur J Pharmacol2002，448，23： | 1 |
| 12 | Both inhibition and enhanced expression of miR‐31 lead to reduced migration and invasion of pancreatic cancer cells显示文摘 | Eeva M.Laurila SaanaSandstr?m Laura M.Rantanen ReijaAutio AnneKallioniemi | 2012 | Genes Chromosom Cancer2012，，6： | 1 |
| 13 | Acid Catalysis by Heteropoly Acids 显示文摘 | Timot'eeva M N | 2003 | Appl Catal A2003，256，12： | 1 |
| 14 | 8q24 amplification intransitional cell carcinoma ofbladder 显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl Immunohistochem MolMorphol2003，11，1： | 1 |
| 15 | Calcineurin inhibitors,cyclosporine A and tacrolimus inhibit expression of inducible nitricoxide synthase in colon epithelial and macrophage cell lines显示文摘 | MARI H ALEKSI L EEVA M | 2002 | Eur J Pharmaeol2002，448，23： | 1 |
| 16 | Serum tartrate-resistant acid phosphatase 5b (TRACP 5b) as a marker of skeletal changes in prostate cancer显示文摘 | Eeva Salminen M Ala-Houhala J Korpela M Varpula S. L. Tiitinen J. M. Halleen H. K V??n?nen | 2005 | Acta Oncologica2005，，7： | 1 |
| 17 | 8q24 amplification in transitional cellcarcinoma of bladder显示文摘 | Visapaa H Seligson D Eeva M | 2003 | Appl Immunohistochem Mol Morphol2003，11，： | 1 |
| 18 | Global burden of disease and injury due to occupational factors 显示文摘 | JAMES L PETRA M EEVA K | 1999 | Epidemiology1999，10，5： | 1 |
| 19 | 8q24 amplification intransitional cell carcinoma of bladder 显示文摘 | Visapaa H Swligson D Eeva M | 2003 | Appl Immunohistochem Mol Morpho2003，11，1： | 1 |
| 20 | Reciprocal regulation of SOCS1 andSOCS3 enhances resistance to ionizing radiation in glioblastoma multi-form显示文摘 | Zhou H Miki R Eeva M | 2007 | Clin Cancer Res2007，13，8： | 1 |
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