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| 1 | Analysis of the phosphatidylinosit ol 3'-kinase signaling pathway in glioblastoma patients in vivo显示文摘Deregulated signaling through the p hosphatidylinositol 3-kinase(PI3K)pathway is common in many types of can cer,including glioblastoma.Dissecting the molecular events associated with activation of this pathway in glioblastoma p atients in vivo presents an important challenge that has implic ations for the development and clini cal testing of PI3K pathway inhibito rs.Using an immunohistochemical analysis appl ied to a tissue microarray,we performed hierarchical clustering and mul tidimensional scaling,as well as univariate and multivariate analyses,to dissect the PI3K pathway in v ivo.We demonstrate that loss of the t umor suppressor protein PTEN,which antagonizes PI3K pathwa y activation,is highly correlated w ith activation of the main PI3K effec tor Akt in vivo.We also show that Akt activation is signific antly correlated with phosphorylation of mammalian target of rapamycin(mTOR),the family of forkhead transcription factors(FOXO1,FOXO3a,and FOXO4),and S6,which are thought to promote its effects.Expression of the mutan t epidermal growth factor receptor vIII is also tightly correlated with phosphorylation of these effectors,d emonstrating an additional route to PI3K pathway activation in glioblastomas in vivo.These results provide the first dissection of the PI3K path way in glioblastoma in vivo and suggest an approach to stratifying patients for targeted kinase inhi bitor | Choe G Horvath S Cloughesy TF Crosby K Seligson D Palotie A Inge L Smith BL Sawyers CL Mischel PS | 2003 | 癌症2003，22，7： | 41 |
| 2 | Pin tract infection with contemporary external fixation: how much of a problem? 显示文摘 | Parameswaran AD Craig SR Seligson D | 2003 | Orthop Trauma2003，17，7： | 1 |
| 3 | Dynamic external fixation for distal radius fracture显示文摘 | Dienst M Wozasek GE Seligson D | 1997 | Clin Orthop Relat Res1997，，338： | 1 |
| 4 | Pin tract infection with contemporary external fixation:how much of a problem? 显示文摘 | Parameswaran AD Roberts CS Seligson D | 2003 | J Orthop Trauma2003，17，7： | 1 |
| 5 | Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma 显示文摘 | Kim H L Seligson D Liu X | 2005 | J Urol2005，173，5： | 1 |
| 6 | Dynamic external fixation for distal radius fractures 显示文摘 | Wozasek GE Seligson D | 1997 | Clin Orthop1997，338，11： | 1 |
| 7 | Absent CD44v6 expression is an independent predictor of poor urothelial bladder cancer outcome显示文摘 | Klatte T Seligson D B Rao J Y | 2010 | J Urol2010，183，6： | 1 |
| 8 | Dynamic external fixation for distal radius fractures 显示文摘 | Dienst M Wozasek GE Seligson D | 1997 | Clin Orthop Relat Res1997，338，： | 1 |
| 9 | Dynamic external fixation for distal radius fractures显示文摘 | Dienst M Wozasek GE Seligson D | | 0，，338： | 1 |
| 10 | The use of circular fine wire frames for the treatment of displaced intra-articular calcaneal fractures显示文摘 | Mauffrey C Klutts P Seligson D | 2009 | J Orthop Traumatol2009，10，1： | 1 |
| 11 | Dynamic external fixation for distal radius fracture显示文摘 | Dienst M Wozasek GE Seligson D | 1997 | J Clin Orthop1997，338，： | 1 |
| 12 | Dynamic externalfixation for distalradius fractures显示文摘 | Dienst M Wazasek GE Seligson D | 1997 | Clin Orthop1997，，338： | 1 |
| 13 | Dynamic external fixation fordistal radius fractures显示文摘 | Dienst M Woz^ek GE Seligson D | 1997 | Clin Orthop Relat Res1997，，338： | 1 |
| 14 | Absorbable fasteners for the fixation of ankle fractures显示文摘 | George K Becker D Seligson D | 1999 | J Ky Med Assoc1999，97，3： | 1 |
| 15 | Dynamic external fixation for distal radius fracture显示文摘 | Dienst M Wozasek G E Seligson D | 1997 | Chin Orthop Relat Res1997，338，： | 1 |
| 16 | Dynamic external fixation for diatal radius fracture显示文摘 | Dienst M Wozasek GE Seligson D | 1997 | Clin Orthop Relat Res1997，，338： | 1 |
| 17 | Dynamic external fixation for distal radius fracture显示文摘 | Dienst M Wozases GE Seligson D | | 0，，： | 1 |
| 18 | Early and late repair of lateral ligaments of the ankle显示文摘 | Gould N Seligson D Gassman J | | 0，，： | 1 |
| 19 | Dynamic external fixation for distal radius fractures显示文摘 | DIENST M WOZASEK GE SELIGSON D | 1997 | Clin Orthop1997，338，： | 1 |
| 20 | Using protein expressions to predict survival in clear cell renal carcinomar显示文摘 | Kim HL Seligson D Xueli L | 2004 | Cli Can Res2004，10，11： | 1 |
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