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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | Patterns of genomic and phenomic diversity in wine and table grapes显示文摘Grapes are one of the most economically and culturally important crops worldwide,and they have been bred for both winemaking and fresh consumption.Here we evaluate patterns of diversity across 33 phenotypes collected over a 17-year period from 580 table and wine grape accessions that belong to one of the world’s largest grape gene banks,the grape germplasm collection of the United States Department of Agriculture.We find that phenological events throughout the growing season are correlated,and quantify the marked difference in size between table and wine grapes.By pairing publicly available historical phenotype data with genome-wide polymorphism data,we identify large effect loci controlling traits that have been targeted during domestication and breeding,including hermaphroditism,lighter skin pigmentation and muscat aroma.Breeding for larger berries in table grapes was traditionally concentrated in geographic regions where Islam predominates and alcohol was prohibited,whereas wine grapes retained the ancestral smaller size that is more desirable for winemaking in predominantly Christian regions.We uncover a novel locus with a suggestive association with berry size that harbors a signature of positive selection for larger berries.Our results suggest that religious rules concerning alcohol consumption have had a marked impact on patterns of phenomic and genomic diversity in grapes. | ZoëMigicovsky Jason Sawler Kyle M Gardner Mallikarjuna K Aradhya Bernard H Prins Heidi R Schwaninger Carlos D Bustamante Edward S Buckler Gan-Yuan Zhong Patrick J Brown Sean Myles | 2017 | Horticulture Research2017，4，1： | 3 |
| 5 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 6 | The Surgical Treatment and Outcome of Nonmetastatic Extremity Osteosarcoma with Pathological Fractures显示文摘 | Zhi-Ping Deng Yi Ding Ajay Puri Edward H M Wang Ashish Gulia Claire Durban Xiao-Hui Niu | 2015 | Chinese Medical Journal2015，，19： | 2 |
| 7 | Studies to determine whether an interaction exists among boron,calcium and cholecalciferol on the skeletal development of broiler chicks显示文摘 | Eliot M A Edwards H M | 1992 | Poultry Science1992，71，4： | 1 |
| 8 | Changes in Diabetes Self-Care Behaviors Make a Difference in Glycemic Control:The Diabetes Stages of Change(Disc)Study显示文摘 | Jones H Edwards L Vallis T M | | 0，，3： | 1 |
| 9 | A decade of raman spectroscopy in art and archaeology 显示文摘 | VANDENABEELE P EDWARDS H G M MOENS L | 2007 | Chemical Reviews2007，107，： | 1 |
| 10 | Foreign language aptitude and intelligence显示文摘 | Wesche M Edwards H & Wells W | 1982 | Applied Psycholinguistics1982，，3： | 1 |
| 11 | Optinization modeling of water quality in an uncertain environment显示文摘 | Donald H B Edward A M | 1985 | Water Resource Research1985，21，7： | 1 |
| 12 | Sea floor bioaheration of sulfide minerals: results from in situ incubation studies显示文摘 | Edwards K J Mccollom T M Konishi H | 2003 | Geoehimica et Cosmochimica Aeta2003，67，28： | 1 |
| 13 | The diffraction of a planar detonation wave at an abrupt area change 显示文摘 | Edwards D H Thomas G O Nettleton M A | 1979 | Journal of Fluid Mechanics1979，95，： | 1 |
| 14 | High resolution characterization of the asian monsoon between 146 0013 and 99 0013 years B P from Dongge Cave, China and global correlation of events surrounding Termination Ⅱ 显示文摘 | Kelly M J Edwards L R Cheng H | 2006 | Palaeogeography Palaeeclimatology Palaeoecology 20062006，236，： | 1 |
| 15 | Image segmentation from scale and rotation invariant texture features from the double dyadic dual-tree complex wavelet transform显示文摘 | Edward H S L Pickering M R Frater M R | | 0，，01： | 1 |
| 16 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 17 | Instabilities in Detonation Waves Near the Limits of Propagation 显示文摘 | Edwards D H Morgan J M | 1977 | Journal of Physics D: Applied Physics1977，10，17： | 1 |
| 18 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 19 | Water absorption and states of water in smicrystalline poly (vinyl alcohol ) films 显示文摘 | Hodge R M Edward G H Simon G P | 1996 | Polymer1996，37，： | 1 |
| 20 | Shock Diffraction in Channels with 90° Bends 显示文摘 | Edwards D H Fearnley P Nettleton M A | 1983 | Fluid Mech1983，132，： | 1 |
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