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| 1 | Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation显示文摘Severe pandemic influenza A(H1N1)2009 virus(pH1N1)infection causes significant morbidity and mortality.We and other groups have reported that immunopathological damage induced by excessive pulmonary inflammation plays a critical role in the pathogenesis of severe pneumonia and provides novel strategies for the treatment of severe influenza infection[1–3].The complement system plays critical roles in both innate and adaptive immunity by activating the classical,alternative and lectin pathways[4]. | Xu Wu Linlin Bao Ziqi Hu Duoduo Yao Fengdi Li Hui Li Xiaoxue Xu Yunqing An Xi Wang Bin Cao Xulong Zhang | 2021 | Cellular & Molecular Immunology2021，18，9： | 6 |
| 2 | Effect of Chinese tuina massage therapy on resting state brain functional network of patients with chronic neck pain显示文摘Objective:Cervical disease,a type of chronic pain,can greatly impact quality of life.Traditional Chinese tuina,a form of therapeutic massage and manipulation,has been shown to be effective in relieving pain and other symptoms in patients with chronic neck pain.This study applied functional magnetic resonance imaging (fMRI) to explore the features of the resting state network of patients with chronic neck pain caused by cervical radiculopathy,and how tuina affects the causality between intrinsic brain networks.Methods:Using Granger causality analysis,effective connectivity of brain networks of 10 patients with chronic neck pain was compared with 10 healthy control subjects.Resting state fMRI data were using magnetic resonance scanning.Cervical spondylosis symptom scores were evaluated before and after 4 weeks of tuina therapy.Independent component analysis was applied to extract the specific networks related to sensation,execution,and cognition,including sensorimotor network (SMN),visual network (VN),auditory network (AN),anterior and posterior default mode network (aDMN,pDMN),left frontoparietal network and right frontoparietal network.Results:Compared with the control group,data from the treatment group revealed two major findings:before tuina therapy,SMN had a profound influence on aDMN and AN greatly affected pDMN;however,after 4 weeks of tuina therapy,aDMN and SMN showed reversed causality.Conclusion:Chronic neck pain caused by cervical radiculopathy may influence the DMN,which plays an important role in emotion,cognition,and memory,by stimulating the sensory afferent network.Tuina not only significantly relieves pain and discomfort,but also reverses the causality between aDMN and SMN. | Hua Zhang Hong Chen Hao Wang Duoduo Li Baolin Jia Zhongjian Tan Bin Zheng Zhiwen Weng | 2015 | Journal of Traditional Chinese Medical Sciences2015，2，1： | 3 |
| 3 | Optimal exercise intensity and volume to impact rats with Traditional Chinese Medicine phlegm-dampness constitution显示文摘Objective:We aim to investigate the effects of different exercise intensities and volumes on Phlegm-dampness constitution(PDC).Methods:The rats were fed with high-fat food and lived in 75%–85%humidity for 6 weeks to establish the model of PDC.Then PDC rats were screened and intervened by varying exercise intensities for 8 weeks.Weight,constitution scores,blood and liver tissues were collected to detect the concentration of serum total cholesterol(Tch),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),homocysteine(Hcy),blood glucose(GLU),alanine transaminase(ALT)and percentage of lipid droplet area in liver tissue(PLDA).Results:The weight,Tch,TG,HDL-C,LDL-C,Hcy,GLU,and ALT of rats in moderate-intensity exercise group returned to normal.The rats with high-intensity or low-intensity exercise did not recover as well as moderate-intensity.Conclusion:Different exercise intensities and volumes have different effects on PDC,moderate-intensity exercise over an 8-week intervention is most appropriate. | Zhangmeng Xu Yong Chen Duoduo Yu Donghong Feng Chenjian Tang Tao Li Jing Zhou Yaming Yu | 2021 | Sports Medicine and Health Science2021，3，1： | 1 |
| 4 | Getting Their Voices heard:Three Cases of Public Participation in Environmental Protection in China显示文摘 | Li Wanxin Liu Jieyan Li Duoduo | 2012 | Journal of Environmental Management2012，98，15： | 1 |
| 5 | Development and application of molecular markers for TSW(thousand-seed weight)related gene BnaGRF7.C02 in Brassica napus显示文摘Brassica napus L(rapeseed)is one of the most important oil crops with large cultivated area in China.Seed size and seed weight play crucial roles for yield and harvest.In this study,a type of 15 bp-deletion in BnaGRF7.CO2 coding region was identified through sequence alignment of BnaGRF7.C02 in 42 rapeseed varieties,and associ-ation analysis indicated that the 15 bp-deletion was related to the rapeseed Thousand-Seed Weight(TSW)phenotype.Furthermore,we developed two InDel markers to identify this 15 bp InDel.The tissue-specific expression patterns showed that BnaGRF7.C02 prominently expressed in the late stage of seed development.These findings may assist in InDel markers-based breeding efforts to select higher TWS varieties and improve the crop yield of B.nqpus. | Jing Zhao Chanyu Jin Rui Geng Yixuan Xue Minqiang Tang Keming Zhu Yulong Li Duoduo Wang Shengyi Liu Xiaoli Tan | 2021 | Oil Crop Science2021，6，3： | 0 |
| 6 | New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine显示文摘Over the past thirty years,the importance of chemokines and their seven-transmembrane G protein-coupled receptors(GPCRs)has been increasingly recognized.Chemokine interactions with receptors trigger signaling pathway activity to form a network fundamental to diverse immune processes,including host homeostasis and responses to disease.Genetic and nongenetic regulation of both the expression and structure of chemokines and receptors conveys chemokine functional heterogeneity.Imbalances and defects in the system contribute to the pathogenesis of a variety of diseases,including cancer,immune and inflammatory diseases,and metabolic and neurological disorders,which render the system a focus of studies aiming to discover therapies and important biomarkers.The integrated view of chemokine biology underpinning divergence and plasticity has provided insights into immune dysfunction in disease states,including,among others,coronavirus disease 2019(COVID-19).In this review,by reporting the latest advances in chemokine biology and results fromanalyses of a plethora of sequencing-based datasets,we outline recent advances in the understanding of the genetic variations and nongenetic heterogeneity of chemokines and receptors and provide an updated view of their contribution to the pathophysiological network,focusing on chemokine-mediated inflammation and cancer.Clarification of the molecular basis of dynamic chemokine-receptor interactions will help advance the understanding of chemokine biology to achieve precision medicine application in the clinic. | Hanli Xu Shuye Lin Ziyun Zhou Duoduo Li Xiting Zhang Muhan Yu Ruoyi Zhao Yiheng Wang Junru Qian Xinyi Li Bohan Li Chuhan Wei Keqiang Chen Teizo Yoshimura Ji Ming Wang Jiaqiang Huang | 2023 | Cellular & Molecular Immunology2023，20，7： | 0 |
| 7 | Trends in the Prevalence of Births with Chromosomal Abnormalities—Haidian District,Beijing Municipality,China,2013–2022显示文摘Summary What is already known about this topic?The primary causes of early miscarriage and stillbirth are chromosomal abnormalities(CAs)whose prevalence has been observed to increase in recent years.What is added by this report?According to data received from a hospital-based birthdefect surveillance system in the Haidian District,Beijing,there was a significant increase in the prevalence of CAs along with most subtypes from 2013 to 2022. | Shuangbo Xia Chao Meng Xiao Cheng Duoduo Wang Yaxian Wu Zhiwen Li Yuan Wei Jufen Liu | 2023 | China CDC weekly2023，5，36： | 0 |
| 8 | Prevalence and Trends of Birth Defects—Five Counties,Shanxi Province,China,2003–2022显示文摘Summary What is already known about this topic?The Shanxi Province,located in northern China,holds the highest prevalence of birth defects(BDs)across the country.Following the implementation of a nationwide folic acid supplementation program in 2009,a significant reduction of 53.89%in the prevalence of neural tube defects(NTDs)was observed in Shanxi from 2012 to 2017. | Duoduo Wang Zhijiao Song Yali Zhang Le Zhang Lei Jin Aiguo Ren Zhiwen Li Jufen Liu | 2023 | China CDC weekly2023，5，36： | 0 |
| 9 | World Book and Copyright Day显示文摘Writerson Reading Chinese President Xi Jinping has repeatedly stressed the importance of reading books so as to enhance the Chinese people's mental development and build a society of reading.On the eve of World Book and Copyright Day on April 23,we invited some prolific writers to share their stories of reading and writing,as well as their thoughts on the development of a national reading culture and the international promotion of Chinese culture.They include Qiu Huadong,Mai Jia,Tan Kai,Li Chaoquan,Xu Zechen and Ye Duoduo. | Qiu Huadong Mai Jia Tan Kai Li Chaoquan Xu Zechen Ye Duoduo | 2023 | China News Release2023，，4： | 0 |
| 10 | Acute ST-elevation myocardial infarction in a patient with polycythemia vera显示文摘To the editor:Little is known about the management of acute myocardial infarction (AMI) in patient with polycythemia vera (PV),especially in those with primary percutaneous coronary intervention (PCI). | Zhang Wei Zhang Yan Liu Yuguo Gokool Indivar Rai Zhang Duoduo Li Pai Kong Jingjing Wang Yanfu Zhou Xuchen | 2014 | Chinese Medical Journal2014，，2： | 0 |
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