|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Crustal deformation on the Chinese mainland during 1998—2004 based on GPS data显示文摘This study focuses on resolving moderate amounts of crustal motion at the continental scale based on a large volume of global positioning system(GPS) data during 1998e2014. A state-of-the-art GPS processing strategy was used to resolve position time series and velocities from carrier beat phases for all available data. Position time series were closely analyzed to estimate linear constant, coseismic displacements, postseismic motions, and other parameters. We present coseismic offsets inferred from the GPS data for the 2010 Yushu and 2014 Yutian earthquakes, and also illustrate transient postseismic motions following the 2001 Kokoxili, 2008 Wenchuan, and 2011 Tohoku-Oki earthquakes. Since not all GPS position time series dominated by postseismic motions can be modeled and corrected reasonably, we present contemporary horizontal velocities from 2009 to 2014 for campaign stations and from 1998 to 2014 for continuous stations, irrespective of postseismic deformations. Our study concludes that we need to accumulate observations over a greater duration and apply accurate postseismic modeling to correct for transient displacement in order to resolve reasonable interseismic velocity. | Zhao Bin Huang Yong Zhang Caihong Wang Wei Tan Kai Du Rinlin | 2015 | Geodesy and Geodynamics2015，6，1： | 50 |
| 2 | Effects of Blade Number on Characteristics of Centrifugal Pumps显示文摘The blade number of impeller is an important design parameter of pumps,which affects the characteristics of pump heavily.At present,the investigation focuses mostly on the performance characteristics of axis flow pumps,the influence of blade number on inner flow filed and characteristics of centrifugal pump has not been understood completely.Therefore,the methods of numerical simulation and experimental verification are used to investigate the effects of blade number on flow field and characteristics of a centrifugal pump.The model pump has a design specific speed of 92.7 and an impeller with 5 blades.The blade number is varied to 4,6,7 with the casing and other geometric parameters keep constant.The inner flow fields and characteristics of the centrifugal pumps with different blade number are simulated and predicted in non-cavitation and cavitation conditions by using commercial code FLUENT.The impellers with different blade number are made by using rapid prototyping,and their characteristics are tested in an open loop.The comparison between prediction values and experimental results indicates that the prediction results are satisfied.The maximum discrepancy of prediction results for head,efficiency and required net positive suction head are 4.83%,3.9% and 0.36 m,respectively.The flow analysis displays that blade number change has an important effect on the area of low pressure region behind the blade inlet and jet-wake structure in impellers.With the increase of blade number,the head of the model pumps increases too,the variable regulation of efficiency and cavitation characteristics are complicated,but there are optimum values of blade number for each one.The research results are helpful for hydraulic design of centrifugal pump. | LIU Houlin WANG Yong YUAN Shouqi TAN Minggao WANG Kai | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 28 |
| 3 | Ibrolipim increases ABCA1/G1 expression by the LXRα signaling pathway in THP-1 macrophage- derived foam cells显示文摘 | Si-guo CHEN Ji XIAO Xie-hong LIU Mei-mei LIU Zhong-cheng MO Kai YIN Guo-jun ZHAO Jin JIANG Li-bao CUI Chun-zhi TAN Wei-dong YIN Chao-ke TANG | 2010 | Acta Pharmacologica Sinica2010，31，10： | 18 |
| 4 | Three-dimensional reconstruction of digitized human liver: based on Chinese Visible Human显示文摘与作比较的背景二维(2D ) 成像,两个在诊断和治疗,三维(3D ) 成像在临床的药有许多优点。3D 重建使目标更容易识别并且比 2D 成像更好揭示机关的体积和形状。A 3D 数字化肝的可见模型被造为肝的操作计划并且为在腹部的横向的节从中国可见人的数据集被选择的 computer.Methods 上认识到肝的精确模拟提供解剖结构。并且 Amira 软件被选择分割并且重建肝的结构。肝被重建在与表面和精确地分割的体积显示 reconstruction.Results 三尺寸肝的主要结构的图象被完成。重建的结构能单身地被显示,在小组或总体上并且能连续地在不同速度在 3D 空间被旋转。结论重建的肝是现实主义的,它表明自然形状和肝结构的准确位置。它为自动化分割提供一个精确模型算法的学习和看肝的一个数字化的解剖模式。 | CHEN Gang LI Xue-cheng WU Guo-qing ZHANG Shao-xiang XIONG Xiao-feng TAN Li-wen YANG Ri-gao LI Kai YANG Shi-zhong DONG Jia-hong | 2010 | Chinese Medical Journal2010，，2： | 18 |
| 5 | Numerical Research on Performance Prediction for Centrifugal Pumps显示文摘Performance prediction for centrifugal pumps is now mainly based on numerical calculation and most of the studies merely focus on one model. Therefore, the research results are not representative. To make an improvement of numerical calculation method and performance prediction for centrifugal pumps, performance of six centrifugal pump models at design flow rate and off design flow rates, whose specific speed are different, were simulated by using commercial code FLUENT. The standard k-ε turbulence model and SIMPLEC algorithm were chosen in FLUENT. The simulation was steady and moving reference frame was used to consider the impeller-volute interaction. Also, how to dispose the gap between impeller and volute was presented and the effect of grid number was considered. The characteristic prediction model for centrifugal pumps is established according to the simulation results. The head and efficiency of the six models at different flow rates are predicted and the prediction results are compared with the experiment results in detail. The comparison indicates that the precision of head and efficiency prediction are all less than 5%. The flow analysis indicates that flow change has an important effect on the location and area of low pressure region behind the blade inlet and the direction of velocity at impeller inlet. The study shows that using FLUENT simulation results to predict performance of centrifugal pumps is feasible and accurate. The method can be applied in engineering practice. | TAN Minggao YUAN Shouqi LIU Houlin WANG Yong WANG Kai | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 15 |
| 6 | Spectral analysis of bowel sounds in intestinal obstruction using an electronic stethoscope显示文摘AIM: To determine the value of bowel sounds analysis using an electronic stethoscope to support a clinical diagnosis of intestinal obstruction. METHODS: Subjects were patients who presented with a diagnosis of possible intestinal obstruction based on symptoms, signs, and radiological findings. A 3MTH Littmann Model 4100 electronic stethoscope was used in this study. With the patients lying supine, six 8-second recordings of bowel sounds were taken from each patient from the lower abdomen. The recordings were analysed for sound duration, soundto-sound interval, dominant frequency, and peak frequency. Clinical and radiological data were reviewed and the patients were classified as having either acute, subacute, or no bowel obstruction. Comparison of bowel sound characteristics was made between these subgroups of patients. In the presence of an obstruction, the site of obstruction was identified and bowel calibre was also measured to correlate with bowel sounds. RESULTS: A total of 71 patients were studied during the period July 2009 to January 2011. Forty patientshad acute bowel obstruction (27 small bowel obstruction and 13 large bowel obstruction), 11 had subacute bowel obstruction (eight in the small bowel and three in large bowel) and 20 had no bowel obstruction (diagnoses of other conditions were made). Twenty-five patients received surgical intervention (35.2%) during the same admission for acute abdominal conditions. A total of 426 recordings were made and 420 recordings were used for analysis. There was no significant difference in sound-to-sound interval, dominant frequency, and peak frequency among patients with acute bowel obstruction, subacute bowel obstruction, and no bowel obstruction. In acute large bowel obstruction, the sound duration was significantly longer (median 0.81 s vs 0.55 s, P = 0.021) and the dominant frequency was significantly higher (median 440 Hz vs 288 Hz, P = 0.003) when compared to acute small bowel obstruction. No significant difference was seen between acute large bowel obstruction and large bowel pseudoobstruction. For patients with small bowel obstruction, the sound-to-sound interval was significantly longer in those who subsequently underwent surgery compared with those treated non-operatively (median 1.29 s vs 0.63 s, P < 0.001). There was no correlation between bowel calibre and bowel sound characteristics in both acute small bowel obstruction and acute large bowel obstruction. CONCLUSION: Auscultation of bowel sounds is nonspecific for diagnosing bowel obstruction. Differences in sound characteristics between large bowel and small bowel obstruction may help determine the likely site of obstruction. | Siok Siong Ching Yih Kai Tan | 2012 | World Journal of Gastroenterology2012，18，33： | 14 |
| 7 | 结直肠癌NOSE术的近期效果及对机体细胞免疫功能影响的研究显示文摘目的探讨腹腔镜结直肠癌标本经自然腔道取出手术(natural orifice specimen extraction,NOSE)的近期效果及对患者细胞免疫功能的影响。方法收集湖北省肿瘤医院2014年9月至2016年3月期间接受腹腔镜结直肠癌根治手术的89例患者的临床病理资料,其中标本经肛门取出的腹腔镜结直肠癌根治术患者31例(NOSE组),传统腹腔镜辅助结直肠癌根治术患者58例(LAP组),比较两组患者手术的近期效果及细胞免疫功能指标变化。结果两组患者术前的各临床指标及细胞免疫功能指标相似,差异均无统计学意义(均P>0.05)。患者手术时间、手术并发症发生率及淋巴结检出数目两组差异均无统计学意义(均P>0.05)。NOSE组术后疼痛评分(2.8±0.9分)显著少于LAP组(3.7±1.2分),(t=3.766,P<0.001)。NOSE组和LAP组患者术后排气时间分别为2.6±0.8 d和3.3±0.8 d,(t=4.427,P<0.001)。NOSE组患者术后住院时间较LAP组短,两组分别为7.8±4.3 d和10.3±5.4 d,(t=2.213,P=0.030)。NOSE组与LAP组患者术后第3天CD4+T细胞与术前相比均有显著下降(均P<0.05),且LAP组术后第3天CD4+T细胞比例更低,两组差异有统计学意义(t=4.017,P=0.002)。术后第3天CD8+T细胞及CD4+/CD8+与术前相比,LAP组下降明显,差异有统计学意义(均P<0.05),而NOSE组下降不明显(均P>0.05)。两组患者术后CRP水平均显著升高(均P<0.05),且LAP组升高更加明显,两组术后第3天、第6天CRP水平差异均有统计学意义,均P<0.05。结论结直肠癌NOSE术与传统腹腔镜辅助手术相比,具有更加优越的微创效果,对患者细胞免疫功能影响更小。 | 胡俊杰 魏少忠 熊治国 杨伯君 Tan Kai | 2016 | 中华结直肠疾病电子杂志2016，5，4： | 11 |
| 8 | RESEARCH OF INNER FLOW IN A DOUBLE BLADES PUMP BASED ON OPENFOAM显示文摘The inner flow analysis of centrifugal pumps has gradually become an important issue for the hydraulic design and performance improvement.Nowadays,CFD simulation toolbox of pump inner flow mainly contains commercial tools and open source tools.There are some defects for commercial CFD software for the numerical simulation of 3-D turbulent internal flow in pump,especially in capturing the flow characteristics under the off-design operating conditions.Additionally,it is difficult for researchers to do further investigation because of the undeclared source.Therefore,an open source software like Open Field Operation and Manipulation (OpenFOAM) is increasingly popular with researchers from all over the world.In this paper,a new computational study was implemented based on the original solver and was used to directly simulate the steady-state inner flow in a double blades pump,with the specific speed is 111.In order to disclose the characteristics deeply,three research schemes were conducted.The ratios () of the flow rate are 0.8,1.0 and 1.2,respectively.The simulation results were verified with the Particle Imaging Velocimetry (PIV) experimental results,and the numerical calculation results agree well with the experimental data.Meanwhile,the phenomena of flow separation under the off-design operating conditions are well captured by OpenFOAM.The results indicate that OpenFOAM possesses obvious strong predominance in computing the internal flow field of pump.The analysis results can also be used as the basis for the further research and the improvement of centrifugal pump. | LIU Hou-lin REN Yun WANG Kai WU Deng-hao RU Wei-min TAN Ming-gao | 2012 | Journal of Hydrodynamics2012，24，2： | 11 |
| 9 | Immunogenicity and safety of a severe acute respiratory syndrome coronavirus 2 inactivated vaccine in healthy adults: randomized, double-blind, and placebo-controlled phase 1 and phase 2 clinical trials显示文摘Background:The significant morbidity and mortality resulted from the infection of a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)call for urgent development of effective and safe vaccines.We report the immunogenicity and safety of an inactivated SARS-CoV-2 vaccine,KCONVAC,in healthy adults.Methods:Phase 1 and phase 2 randomized,double-blind,and placebo-controlled trials of KCONVAC were conducted in healthy Chinese adults aged 18 to 59 years.The participants in the phase 1 trial were randomized to receive two doses,one each on Days 0 and 14,of either KCONVAC(5 or 10 mg/dose)or placebo.The participants in the phase 2 trial were randomized to receive either KCONVAC(at 5 or 10 mg/dose)or placebo on Days 0 and 14(0/14 regimen)or Days 0 and 28(0/28 regimen).In the phase 1 trial,the primary safety endpoint was the proportion of participants experiencing adverse reactions/events within 28 days following the administration of each dose.In the phase 2 trial,the primary immunogenicity endpoints were neutralization antibody seroconversion and titer and anti-receptor-binding domain immunoglobulin G seroconversion at 28 days after the second dose.Results:Inthe phase1 trial,60 participantswere enrolled andreceived at least one dose of 5-mgvaccine(n=24),10-mgvaccine(n=24),or placebo(n=12).In the phase 2 trial,500 participantswere enrolled and received at least one dose of 5-mg vaccine(n=100 for 0/14 or 0/28 regimens),10-mg vaccine(n=100 for each regimen),or placebo(n=50 for each regimen).In the phase 1 trial,13(54%),11(46%),and seven(7/12)participants reported at least one adverse event(AE)after receiving 5-,10-mg vaccine,or placebo,respectively.In the phase 2 trial,16(16%),19(19%),and nine(18%)0/14-regimen participants reported at least oneAEafter receiving 5-,10-mg vaccine,or placebo,respectively.Similar AE incidences were observed in the three 0/28-regimen treatment groups.No AEs with an intensity of grade 3+were reported,expect for one vaccine-unrelated seriousAE(foot fracture)reported in the phase 1 trial.KCONVACinduced significant antibody responses;0/28 regimen showed a higher immune responses than that did 0/14 regimen after receiving two vaccine doses.Conclusions:Both doses of KCONVAC are well tolerated and able to induce robust immune responses in healthy adults.These results support testing 5-mg vaccine in the 0/28 regimen in an upcoming phase 3 efficacy trial.Trial Registration:http://gffzz62a03ee25e6f4a77hffxcwqwvkbnk6ukv.ffgz.tsg.suse.edu.cn/index.aspx(No.ChiCTR2000038804,http://gffzz62a03ee25e6f4a77hffxcwqwvkbnk6ukv.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=62350;No.ChiCTR2000039462,http://gffzz62a03ee25e6f4a77hffxcwqwvkbnk6ukv.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=63353). | Hong-Xing Pan Jian-Kai Liu Bao-Ying Huang Gui-Fan Li Xian-Yun Chang Ya-Fei Liu Wen-Ling Wang Kai Chu Jia-Lei Hu Jing-Xin Li Dan-Dan Zhu Jing-Liang Wu Xiao-Yu Xu Li Zhang Meng Wang Wen-Jie Tan Wei-Jin Huang Feng-Cai Zhu | 2021 | Chinese Medical Journal2021，，11： | 11 |
| 10 | Risk factors of intra-abdominal bacterial infection after liver transplantation in patients with hepatocellular carcinoma显示文摘Objective: To explore the risk factors of intra-abdominal bacterial infection(IAI) after liver transplantation(LT) in patients with hepatocellular carcinoma(HCC). Methods: A series of 82 HCC patients who received LT surgeries in our department between March 2004 and April 2010 was recruited in this study. Then we collected and analyzed the clinical data retrospectively. Statistical analysis system(SPSS) software was adopted to perform statistical analysis. Chi-square test, t-test and Wilcoxon rank sum test were used to analyze the clinical data and compute the significance of the incidences of early-stage IAI after LT for HCC patients. Binary logistic regression was performed to screen out the risk factors, and multiple logistic regression analyses were performed to compute the independent risk factors. Results: A series of 13 patients(13/82, 15.9%) had postoperative IAI. The independent risk factors of postoperative intra-abdominal bacterial infections after LT for HCC patients were preoperative anemia [Hemoglobin(HGB) <90 g/L] and postoperative abdominal hemorrhage(72 hours >400 mL), with the odds ratios at 8.121(95% CI, 1.417 to 46.550, P=0.019) and 5.911(95% CI, 1.112 to 31.432, P=0.037). Conclusions: Postoperative IAI after LT in patients with HCC was a common complication. Preoperative moderate to severe anemia, as well as postoperative intra-abdominal hemorrhage more than 400 mL within the first 72 hours might independently indicate high risk of IAI for these patients. | Kai Nie Rongzheng Ran Weifeng Tan Bin Yi Xiangji Luo Yong Yu Xiaoqing Jiang | 2014 | Chinese Journal of Cancer Research2014，26，3： | 10 |
| 11 | How far is Lignin from being a biomedical material?显示文摘Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant,antibacterial,anti-UV,and good biocompatibility.Natural lignin can be processed through several chemical processes.The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials.Thus,lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery,biosensors,bioimaging,3D printing,tissue engineering,and dietary supplement additive.This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials.Thereafter,we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. | Sigit Sugiarto Yihao Leow Chong Li Tan Guan Wang Dan Kai | 2022 | Bioactive Materials2022，7，2： | 9 |
| 12 | Therapeutic plasma exchange and a double plasma molecular absorption system in the treatment of thyroid storm with severe liver injury: A case report显示文摘BACKGROUND Thyroid storm is resistant to conventional treatments including antithyroid drugs and 131I therapeutic means.Plasma exchange(PE)and double plasma molecular absorption system(DPMAS)can be used as an effective treatment for thyroid storm with severe liver injury.CASE SUMMARY A 52-year-old woman presented with a 10-day history of nausea and vomiting accompanied by yellowing of the skin and mucosa.Further,her free T3(FT3)and FT4 levels were significantly elevated,whereas her thyrotropin level was reduced.After admission,her condition continued to deteriorate,and she presented with continued high fever,vomiting,palpitation,and shortness of breath.After being diagnosed with thyroid storm,the patient was immediately treated with PE combined with DPMAS.Her symptoms improved immediately.After three PE+DPMAS treatments,and she was discharged from the hospital.She was treated with methylprednisolone and methylthimidazole.After six months,the patient spontaneously discontinued methylthimidazole treatment.Her previous clinical manifestations and liver dysfunction reoccurred.The patient was treated with PE+DPMAS two times,and her condition rapidly improved.Liver histopathology indicated immunological liver injury.CONCLUSION Our experience suggests that PE combined with DPMAS can effectively relieve the development of thyroid storm. | You-Wen Tan Li Sun Kai Zhang Li Zhu | 2019 | World Journal of Clinical Cases2019，7，10： | 8 |
| 13 | Experimental investigation of the unsteady flow in a double-blade centrifugal pump impeller显示文摘Particle Image Velocimetry (PIV) technology was used to study the unsteady internal flow in a double-blade centrifugal pump (DBCP) impeller at the design flow rate.Relative velocity distributions and turbulence intensity distributions in the DBCP impeller at six phase conditions were obtained.And mean dimensionless relative velocity,turbulence intensity,mean absolute flow angle,mean relative flow angle,mean dynamic pressure and mean angular momentum distributions at the different radii of impeller were calculated.Results show that from impeller inlet to impeller outlet,turbulence intensities gradually decrease.With the increase of radius r,mean dimensionless relative velocity first decreases and then increases,while variation tendencies of mean absolute flow angle and mean dynamic pressure are the opposite.With the increase of radius r,turbulence intensity and mean relative flow angle first decrease,then increase,and then decrease,while mean angular momentum gradually increases. | LIU HouLin WANG Kai KIM Hyoung-Bum TAN MingGao | 2013 | Science China(Technological Sciences)2013，56，4： | 8 |
| 14 | Horizontal crustal deformation in Chinese Mainland analyzed by CMONOC GPS data from 2009-2013显示文摘In this study,we analyze the regional GPS data of Crustal Movement Observation Network of China( CMONOC) observed from 2009-2013 using the BERNESE GPS software,and then the preliminary results of horizontal velocity field and strain rate field are presented,which could reflect the overall deformation features in the Chinese mainland from 2009-2013.Besides,the velocity error and the probable factors that could influence the estimate of long-term deformation are also discussed. | Wang Wei Wang Dijin Zhao Bin Huang Yong Zhang Caihong Tan Kai Yang Shaomin | 2014 | Geodesy and Geodynamics2014，5，3： | 8 |
| 15 | Additively manufactured biodegradable porous magnesium implants for elimination of implant-related infections:An in vitro and in vivo study显示文摘Magnesium(Mg)alloys that have both antibacterial and osteogenic properties are suitable candidates for orthopedic implants.However,the fabrication of ideal Mg implants suitable for bone repair remains challenging because it requires implants with interconnected pore structures and personalized geometric shapes.In this study,we fabricated a porous 3D-printed Mg-Nd-Zn-Zr(denoted as JDBM)implant with suitable mechanical properties using selective laser melting technology.The 3D-printed JDBM implant exhibited cytocompatibility in MC3T3-E1 and RAW267.4 cells and excellent osteoinductivity in vitro.Furthermore,the implant demonstrated excellent antibacterial ratios of 90.0% and 92.1% for methicillin-resistant S.aureus(MRSA)and Escherichia coli,respectively.The 3D-printed JDBM implant prevented MRSA-induced implant-related infection in a rabbit model and showed good in vivo biocompatibility based on the results of histological evaluation,blood tests,and Mg2+deposition detection.In addition,enhanced inflammatory response and TNF-α secretion were observed at the bone-implant interface of the 3D-printed JDBM implants during the early implantation stage.The high Mg^(2+)environment produced by the degradation of 3D-printed JDBM implants could promote M1 phenotype of macrophages(Tnf,iNOS,Ccl3,Ccl4,Ccl5,Cxcl10,and Cxcl2),and enhance the phagocytic ability of macrophages.The enhanced immunoregulatory effect generated by relatively fast Mg^(2+)release and implant degradation during the early implantation stage is a potential antibacterial mechanism of Mg-based implant.Our findings indicate that 3D-printed porous JDBM implants,having both antibacterial property and osteoinductivity,hold potential for future orthopedic applications. | Kai Xie Nanqing Wang Yu Guo Shuang Zhao Jia Tan Lei Wang Guoyuan Li Junxiang Wu Yangzi Yang Wenyu Xu Juan Chen Wenbo Jiang Penghuai Fu Yongqiang Hao | 2022 | Bioactive Materials2022，7，2： | 8 |
| 16 | An integrated pathway interaction network for the combination of four effective compounds from ShengMai preparations in the treatment of cardiocerebral ischemic diseases显示文摘目的: SMXZF (人参皂甙 Rb1,人参皂甙 Rg1, schizandrin 和 DT-13 的联合) 源于中国传统的药公式 ShengMai 准备) 能够在老鼠减轻服的 ischemia-reperfusion 损害。在这研究,我们使用了网络药理学途径在cardio服的 ischemic diseases.Methods 的处理探索 SMXZF 的机制:在化学预言者之上基于例如化学结构,药理学信息和系统生物学功能的数据分析,一个目标小径相互作用网络被构造在cardio服的局部缺血的处理识别 SMXZF 的潜在的小径和目标。而且,最相关的小径在 TNF-α 被验证;对待的人的脉管的 endothelial EA.hy926 房间和对待 H2O2 的老鼠 PC12 cells.Results : 包括 NF-κ 的三个发信号小径; B 小径,氧化压力小径和 cytokine 网络小径被表明是主要发信号小径。从基因本体论分析的结果根据这些发信号的小径。目标蛋白质被发现与象视觉那样的另外的疾病被联系,肾、新陈代谢的疾病,尽管他们在 cardio 服的 ischemic 疾病上施加了治疗学的行动。而且, SMXZF 不仅 dose-dependently 禁止了 NF-κ 的 phosphorylation; B, p50, p65 和 IKKα /β在 TNF-α对待 EA.hy926 房间,而且在对待 H2O2 的 PC12 cells.Conclusion 调整了 Nrf2/HO-1 小径: NF-κ B 发信号小径,氧化压力小径和 cytokine 网络小径为对 cardio 服的 ischemic 疾病的 SMXZF 的治疗学的行动主要负责。 | Fang LI Yan-ni LV Yi-sha TAN Kai SHEN Ke-feng ZHAI Hong-lin CHEN Jun-ping KOU Bo-yang YU | 2015 | Acta Pharmacologica Sinica2015，36，11： | 7 |
| 17 | A new pyrrole alkaloid from Selaginella moellendorfii Hieron显示文摘One new pyrrole alkaloid,N-(2E)-3-(3,4-dihydrophenyl)prop-N1-(4-aminoburyl)-3-pyrrole formaldehyde (1),was isolated from the whole herbs of Selaginella moellendorfii Hieron.The structure was elucidated by spectroscopic analyses including UV,1R,1D NMR,2D NMR and MS methods.Additionally, compound 1 exhibited potent protective effect against the injury of human umbilical vein endothelial cell(HUVECs) induced by high concentrations of glucose in vitro. | Zhen-Xing Zou Kang-Ping Xu Fu-Shuang Li Hui Zou Min-Zhen Liu Qiong Zhang Kai Yu Lan-Fang Zhao Lei-Hong Tan Gui-Shan Tan | 2013 | Chinese Chemical Letters2013，24，2： | 6 |
| 18 | Study on the Non-Contact FBG Vibration Sensor and Its Application显示文摘一个非接触颤动传感器基于纤维布拉格栅栏 FBG 传感器被介绍了,并且监视旋转的柄的颤动被用来。在纸,我们描述传感器的原则并且使一些成为试验性的分析。分析结果证明传感器的敏感和线性是 1.5 pm/m, 4.11% 分别地 2 mm2.6 公里在测量以内变化。当监视旋转的柄的颤动被用来时,分析旋转的柄的颤动发信号,获得的旋转的批评速度与从旋涡水流传感器获得了那一样。它证实传感器能被用于旋转的柄系统并且为差错监视和旋转机械的诊断的颤动的非接触测量。 | Tianliang LI Yuegang TAN Zude ZHOU Li CAI Sai LIU Zhongting HE Kai ZHENG | 2015 | Photonic Sensors2015，5，2： | 6 |
| 19 | Bioinformatic analysis and functional characterization of the cfem proteins in maize anthracnose fungus Colletotrichum graminicola显示文摘Fungal secreted proteins that contain the Common in Fungal Extracellular Membrane(CFEM)domain are important for pathogenicity.The hemibiotrophic fungus Colletotrichum graminicola causes the serious anthracnose disease of maize.In this study,we identified 24 CgCFEM proteins in the genome of C.graminicola.Phylogenic analysis revealed that these 24 proteins(CgCFEM1–24)can be divided into 2 clades based on the presence of the trans-membrane domain.Sequence alignment analysis indicated that the amino acids of the CFEM domain are highly conserved and contain 8 spaced cysteines,with the exception that CgCFEM1 and CgCFEM24 lack 1 and 2 cysteines,respectively.Ten CgCFEM proteins with a signal peptide and without the trans-membrane domain were considered as candidate effectors and,thus were selected for structural prediction and functional analyses.The CFEM domain in the candidate effectors can form a helical-basket structure homologous to the Csa2 protein in Candida albicans,which is responsible for haem acquisition and pathogenicity.Subcellular localization analysis revealed that these effectors accumulate in the cell membrane,nucleus,and cytosolic bodies.Additionally,5 effectors,CgCFEM6,7,8,9 and 15,can suppress the BAX-induced programmed cell death in Nicotiana benthamiana with or without the signal peptide.These results demonstrate that these 10 CgCFEM candidate effectors with different structures and subcellular localizations in host cells may play important roles during the pathogenic processes on maize plants. | GONG An-dong JING Zhong-ying ZHANG Kai TAN Qing-qun WANG Guo-liang LIU Wen-de | 2020 | Journal of Integrative Agriculture2020，19，2： | 6 |
| 20 | Expanding the scope of application of user innovation theorydA case study of the civil-military integration project in China显示文摘The focus of scholars studying user innovation has been restricted to the interaction between companies and individual users,and how companies can unilaterally exploit values from the value chain between companies and users.We argue that the value chain between the user and manufacturer should be a bilateral value chain in which both the user and manufacturer can conduct their own innovations and provide greater value to the whole value chain.In this paper,using examples from China's civil-military integration project,we took a step forward to apply the user innovation theory in the explanation of inter-sector technological value transfer.The main theoretical contribution of this paper is the expansion of the scope of application of the user innovation theory to inter-sector level research.Studying cases from China's civil-military integration project,we found that the concepts of user and innovator become blurred when we study the phenomenon across time.When we go beyond individual user and manufacturer and shift the focus of our discussion to the level of inter-sector technological value transfer,we will find that it is possible for organizational agents at large to be both users and innovators of technology. | Jhony Choon Yeong Ng Karen Kai Wen Song Qingmei Tan | 2018 | International Journal of Innovation Studies2018，2，1： | 6 |
您所在的机构暂未开通此部分的功能，请联系管理员