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| 1 | Daclatasvir plus asunaprevir in treatment-na?ve patients with hepatitis C virus genotype 1b infection显示文摘AIM To assess daclatasvir plus asunaprevir(d UAL) in treatment-na?ve patients from China's Mainland, Russia and South Korea with hepatitis C virus(HCV) genotype 1 b infection. METHODS Patients were randomly assigned(3:1) to receive 24 wk of treatment with d UAL(daclatasvir 60 mg once daily and asunaprevir 100 mg twice daily) beginning on day 1 of the treatment period(immediate treatment arm) or following 12 wk of matching placebo(placebodeferred treatment arm). The primary endpoint was a comparison of sustained virologic response at posttreatment week 12(SVR12) compared with the historical SVR rate for peg-interferon plus ribavirin(70%) among patients in the immediate treatment arm. The first 12 wk of the study were blinded. Safety was assessed in d UAL-treated patients compared with placebo patients during the first 12 wk(doubleblind phase), and during 24 wk of d UAL in both arms combined.RESULTS In total, 207 patients were randomly assigned to immediate(n = 155) or placebo-deferred(n = 52) treatment. Most patients were Asian(86%), female(59%) and aged < 65 years(90%). Among them, 13% had cirrhosis, 32% had IL28 B non-CC genotypes and 53% had baseline HCV RNA levels of ≥ 6 million IU/m L. Among patients in the immediate treatment arm, SVR12 was achieved by 92%(95% confidence interval: 87.2-96.0), which was significantly higher than the historical comparator rate(70%). SVR12 was largely unaffected by cirrhosis(89%), age ≥ 65 years(92%), male sex(90%), baseline HCV RNA ≥ 6 million(89%) or IL28 B non-CC genotypes(96%), although SVR12 was higher among patients without(96%) than among those with(53%) baseline NS5 A resistanceassociated polymorphisms(at L31 or Y93 H). during the double-blind phase, aminotransferase elevations were more common among placebo recipients than among patients receiving d UAL. during 24 wk of d UAL therapy(combined arms), the most common adverse events(≥ 10%) were elevated alanine aminotransferase and upper respiratory tract infection; emergent grade 3-4 laboratory abnormalities were infrequently observed, and all grade 3-4 aminotransferase abnormalities(alanine aminotransferase, n = 9; aspartate transaminase, n = 6) reversed within 8-11 d. Two patients discontinued d UAL treatment; one due to aminotransferase elevations, nausea, and jaundice and the other due to a fatal adverse event unrelated to treatment. There were no treatment-related deaths.CONCLUSION d UAL was well-tolerated during this phase 3 study, and SVR12 with d UAL treatment(92%) exceeded thehistorical SVR rate for peg-interferon plus ribavirin of 70%. | Lai Wei Fu-Sheng Wang Ming-Xiang Zhang Ji-Dong Jia Alexey A Yakovlev Wen Xie Eduard Burnevich Jun-Qi Niu Yong Jin Jung Xiang-Jun Jiang Min Xu Xin-Yue Chen Qing Xie Jun Li Jin-Lin Hou Hong Tang Xiao-guang Dou Yash Gandhi Wen-Hua Hu Fiona McPhee Stephanie Noviello Michelle Treitel Ling Mo Jun Deng | 2018 | World Journal of Gastroenterology2018，24，12： | 17 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Potential energy curves for the X^1Σ_g^+, B^1△_g and B′~1Σ_g^+ states of C_2 using MRCI and approximate CI methods显示文摘The potential energy curves for the X1Σ g+, B1△g and B′1Σ g+ states of C2 have been studied by using MRC and approximate CI methods, and are benchmarked against the calculations of full configuration in teraction (FCI). The results obtained by MRCI method agree with the FCI very well, and even are accu rate enough to compare other approximate methods as benchmark, when the calculations of FCI ar not feasible. The approximate CI methods mentioned in this paper are reliable for treating chemica problems. | LI AnYang1, WANG YuBin2, DOU YuSheng1,3 & WEN ZhenYi1,2 1 Institute of Bio-information, Chongqing University of Post and Telecommunication, Chongqing 400065, China 2 Institute of Modern Physics, Northwest University, Xi’an 710069, China 3 Department of Physical Sciences, Nicholls State University, PO Box 2022, Thibodaux, LA 70310, U. S. A | 2007 | Science China Chemistry2007，50，5： | 2 |
| 4 | Genotypic analysis of multidrug-resistant Mycobacterium tuberculosis isolates from Mon-terrey,Mexico显示文摘 | Ramaswamy SV Dou SJ Rendon A | 2004 | J Med Microbiol2004，53，2： | 1 |
| 5 | Phosphorus characteristics of dairy feces affected by diets 显示文摘 | Dou Z Knowlton Katharin F Kohn Richard A | 2002 | Journal of Environmental Quality2002，31，： | 1 |
| 6 | Protective effect of naringenin against experimental colitis via suppression of Toll-like receptor 4/NF-κB signaling显示文摘 | Dou W Zhang JJ Sun A | 2013 | Br J Nutr2013，110，4： | 1 |
| 7 | Two-dimensionalgraphene nanoribbons 显示文摘 | Yang X Y Dou X Rouhanipour A | 2008 | J Am Chem Soc2008，130，13： | 1 |
| 8 | Development of Al added high-Cr ODS steels for fuel cladding of next generation nuclear systems显示文摘 | Kimura A Kasada R Iwata N Kishimoto H Zhang C H Isselin J Dou P Lee J H Muthukumar N Okuda T Inoue M Ukai S Ohnuki S Fujisawa T Abe F | | 0，，1： | 1 |
| 9 | Genotypic analysis of multidrug resistant Mycobacterium tuberculosis isolates from Monterrey, Mexico 显示文摘 | Ramaswamy SV Dou SJ Rendon A | 2004 | Med Microbiol2004，53，： | 1 |
| 10 | 1 Effects o f iodine supp lementa tion du ring pregnancy on child growth anddevelopm ent at schoo 1 age显示文摘 | OcDonne 11 KJ Rakem anMA Dou ZH et a | 2002 | Dev M ed Child Neuro2002，44，2： | 1 |
| 11 | Protective effect of narin- genin against experimental colitis via suppression of Toll- like receptor 4/NF-kB signalling显示文摘 | Dou W Zhang JJ Sun A | 2013 | Br J Nutr2013，110，： | 1 |
| 12 | Preparation and application of zeolite beta with super-low SiO2/Al2O3 ratio显示文摘 | KANG S DOU T LI Q DUAN A ZHENG Y PAN H | 2008 | J Porous Materials2008，15，2： | 1 |
| 13 | Management of acute bleeding from a peptic ulcer显示文摘 | GRALNEK I M BARKUN A N BAR- DOU M | 2008 | N Engl J Med2008，359，9： | 1 |
| 14 | Phosphorus characteristics of dairy feces affected by diets显示文摘 | Dou Z Katharin F K Richari A K | 2002 | Journal of Environmental Quality2002，31，： | 1 |
| 15 | Management of agro-pastoral dams in Benin: stakeholders, institutions andrehabilitation research显示文摘 | Kpera G N Aarts N Sai'dou A | 2012 | NJAS-Wageningen Journal of LifeScience2012，6063，： | 1 |
| 16 | Does Source Matter? ExaminingSource Effects in Online Product Reviews 显示文摘 | Dou X Walden J A Lee S | 2012 | Computers in Hu-man Behavior2012，28，5： | 1 |
| 17 | Effect of type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with pul- monary tuberculosis:a potential role in the emergence of muhidrug- resistance显示文摘 | Chang JT Dou HY Yen CL et a/ | 2011 | J Fonn Med Assoc2011，110，6： | 1 |
| 18 | Photolithography-free polymer optical waveguide arrays for optical backplane bus显示文摘 | Dou X Y Wang A X Lin X H | 2011 | Optics Express2011，19，14： | 1 |
| 19 | Ultrafast switching of an electrochromic device based on layered double hydroxide/Prussian blue multilayered films显示文摘 | LIU X X ZHOU A DOU Y | 2015 | Nanoscale2015，7，17： | 1 |
| 20 | Power and life extension of battery-ultracapacitor hybrids显示文摘 | DOU GAL R A LIU S WHITE R E | | 0，，01： | 1 |
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