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| 1 | Correlation of E-selectin gene polymorphisms with risk of ischemic stroke A meta-analysis显示文摘OBJECTIVE: To investigate the association of E-selectin S128R polymorphisms with ischemic stroke. DATA SOURCES: A computer-based online search was conducted in PubMed, Elsevier, Ovid Database, the China National Knowledge Infrastructure, and Wanfang Database between January 1998 and December 2010. STUDY SELECTION: Case-controlled studies addressing the association of the E-selectin polymorphism and ischemic stroke were included in this review. The genotype distribution complied with the Hardy-Weinberg genetic equilibrium. The included reports were evaluated by two authors for strict quality screening. Meta-analysis software, REVMAN 5.1, was used to investigate heterogeneity, pooled odds ratio (OR) and 95% confidence interval (CI) in individual studies. MAIN OUTCOME MEASURES: Genotype and allele distributions at the E-selectin S128R site. RESULTS: Six case-controlled studies were included after screening and application of inclusion and exclusion criteria. There was no heterogeneity in the genotype and allele frequencies, and no publication bias was found. Meta-analysis of the pooled data showed that the OR value of the (AC+CC)/AA genotype was 1.93 (95% CI: 1.55-2.41, Z = 5.80, P < 0.000 01), and the OR for the C/A allele was 1.80 (95% CI: 1.47-2.22, Z = 5.59, P < 0.000 01) in the ischemic stroke group, compared with control group. Results of pooled data in Chinese subjects showed that the OR value of (AC+CC)/AA was 2.36 (95% CI: 1.68-3.31, Z = 4.99, P < 0.000 01), and the OR value of the C/A allele was 2.25 (95% CI: 1.63-3.12, Z = 4.89, P < 0.000 01). CONCLUSION: Polymorphism of E-selectin S128R was significantly associated with susceptibility to ischemic stroke; the AC and CC genotypes as well as the C allele may be factors associated with susceptibility to ischemic stroke. | Qingli Sun Yu Fu Aping Sun Yanhong Shou Mei Zheng Xiaogang Li Dongsheng Fan | 2011 | Neural Regeneration Research2011，6，22： | 46 |
| 2 | Dek35 Encodes a PPR Protein that Affects cis-Splicing of Mitochondrial nad4 Intron 1 and Seed Development in Maize显示文摘 | Xinze Chen Fan Feng Weiwei Qi Liming xu Dongsheng Yao Qun Wang Rentao Song | 2017 | Molecular Plant2017，10，3： | 24 |
| 3 | Underground pressure characteristics analysis in back-gully mining of shallow coal seam under a bedrock gully slope显示文摘我们在一个基岩溪谷斜坡下面在浅煤缝接在背溪谷采矿期间学习了地下的压力和它的机制,借助于物理模拟,数字建模并且地监视。结果证明地下的压力的紧张与它在 coalface 的相对位置有关。地下的压力是集中的,当 coalface 在溪谷的底部时,支持抵抗到达最大值,而地下的压力是中等的并且当 coalface 传递溪谷时,逐渐地减少。当斜坡在不稳定的、多边的块依赖了的采矿和形式组织的背溪谷期间在一个颠倒的方向旋转了到斜坡剧降时,这些变化的机制被分析,由于滑倒。当块破碎是小的时,多边的块的沉淀是可观的,导致在地下的压力的庞大的变化。随块身体的团的增加,块排水量将被减少与一起一增加在废矿由未破损的岩石和破岩石夹钳效果,导致地下的压力的减少。 | Wang Xufeng Zhang Dongsheng Fan Gangwei Zhang Chengguo | 2011 | Mining Science and Technology2011，21，1： | 16 |
| 4 | Ages of the Laocheng Granitoids and Crustal Growth in the South Qinling Tectonic Domain,Central China:Zircon U-Pb and Lu-Hf Isotopic Constraints显示文摘Laocheng granitoid pluton 位于 Qinling erogenic 带的南方 Qinling 构造领域,南部的 Shaanxi 省,并且由石英闪长岩, granodiorite 和 monzogranite 主要组成。LA-ICP-MS 锆石 U-Pb 与阴极射线发光图象一起,同位素的标明日期表明石英闪长岩和 granodiorite 是从 220 妈的 emplaced 到 216 妈,当 monzogranite 是在 210 妈的 emplaced 时。在原处,锆石 Hf 同位素的分析证明从 8.1 的石英闪长岩和到 +1.3 的 granodiorite 范围的 Hf (t)价值,和单个阶段的 Hf 从 809 妈为年龄建模到 1171 妈,当 monzogranite 的 Hf (t)价值是 14.5 到 +16.7 和单个阶段的 Hf 时,从 189 妈为年龄建模到 1424 妈。这些 Hf 同位素的特征表明石英闪长岩, granodiorite 和 monzogranite 从混合从弄空的披风和更低的大陆的部分融化导出的岩浆被形成外壳的材料,并且在 Neoproterozoic ( 800 妈)和 Indosinian ( 210 妈)期间有大陆人外壳生长的二个阶段分别地,时代在 Qinling orogrnic 的南方 Qinling 构造领域系上带子,华中。 | YANG Pengtao LIU Shuwen LI Qiugen ZHANG Fan WANG Zongqi WANG Dongsheng WANG Ruiting YAN Quanren YAN Zhen | 2011 | Acta Geologica Sinica(English Edition)2011，85，4： | 15 |
| 5 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 6 | Characteristics and stability of slope movement response to underground mining of shallow coal seams away from gullies显示文摘Underground pressure is abnormal during mining of shallow coal seams under gullies. We studied gully slope movements, subject to underground mining, with physical simulation and theoretical analysis. The rules disclose that the slope rock slides horizontally in response to mining in the direction of gullies and rotates reversely with the appearance of a polygon block in mining away from gullies. We focused our attention on the case of mining away from a gully. We built a mechanical model in terms of a polygon block hinged structure and investigated the variation of horizontal thrust and shear force at the hinged point in relation to the rotation angle under different fragmentations. The Sliding-Rotation instability conditions of the polygon block hinged structure are presented based on the analyses of sliding instability and rotation instability. These results can serve as a theoretical guide for roof control during mining away from gullies in a coalfield defined by gullies. | Zhang Dongsheng Fan Gangwei Wang Xufeng | 2012 | International Journal of Mining Science and Technology2012，22，1： | 8 |
| 7 | Applicable conditions for a classification system of aquifer-protective mining in hallow coal seams显示文摘Based on the conclusions of domestic and foreign research, we have analyzed the collapse-fall characteristics of overlying strata and the mechanism of aquifer-protective mining in shallow coal seam working faces at the Shendong Mine. We have selected the height of the water-conducting fracture zone in overlying strata as a composite index and established the applicable conditions of aquifer-protective mining in shallow coal seams with a multi-factor synthetic-index classification method. From our calculations and analyses of variance, we used factors such as the overlying strata strength, mining disturbing factors and rock integrity as related factors of the composite index. We have classified the applicable conditions of aquifer-protective mining in shallow coal seams into seven types by comparing the result of the height of water-conducting fractured zones of long-wall and short-wall working faces with the thickness of the bedrock, the thickness of the weathered zone and the size of safety coal-rock pillars. As a result, we propose the preliminary classification system of aquifer-protective mining in shallow coal seams. It can provide a theoretical guidance for safe applications of aquifer-protective mining technology in shallow coal seams under similar conditions. | Liu Yude Zhang Dongsheng Fan Gangwei Yah Shoufeng | 2011 | Mining Science and Technology2011，21，3： | 4 |
| 8 | Optimized pre-treatment of high strength food waste digestate by high content aluminum-nanocluster based magnetic coagulation显示文摘Coagulation-based pre-treatment efficiency of high strength digestate of food waste(HSDFW) anaerobic digestion is negated by organic ligand-catalyzed decomposition of coagulants. In this study, an efficient HSDFW pre-treatment method, magnetic seeds(MS) coagulation, was employed by using highly stable Keggin Al_(30) nanocluster(PAC_(30)), MS and polyacrylamide(PAM), and its operation was optimized by evaluating the performance of removing turbidity, total suspended solids(TSS), chemical oxygen demand(COD), and total phosphorous(TP) phosphate. Results showed that at the optimum dosage of 4.82 g/L, PAC_(30) demonstrated excellent removals as high as 98.93% ± 0.1% of turbidity, 98.04% ± 0.1% of TSS, 58.28% ± 0.3% of total COD, 99.98% ± 0.01% of TP and 99.50% ± 0.01% of dissolved phosphate, respectively. Apparent molecular weight(AMW) and three-dimensional excitation-emission matrix(3 D-EEM) fluorescence spectroscopy analyses demonstrated more efficient removal of dissolved organic matter(DOM), particularly non-biodegradable and hydrophobic components by PAC_(30) than commercial coagulant. The sedimentation was much improved from 40 min by coagulation/flocculation to about 5 min settling by MS coagulation. The PAC_(30) based magnetic coagulation(MC) presents theoretical guidance on a cost-effective and much less footprint pre-treatment alternative for high strength wastewater. | Tharindu Ritigala Hailu Demissie Yanlin Chen Jiaxi Zheng Libing Zheng Jinxing Zhu Hua Fan Jiao Li Dongsheng Wang Sujithra KWeragoda Rohan Weerasooriya Yuansong Wei | 2021 | Journal of Environmental Sciences2021，33，6： | 4 |
| 9 | Thermal deformation behavior and microstructure of nuclear austenitic stainless steel显示文摘Gleeble-1500D thermal simulation tester was employed in the hot-compression investigation of as-cast nuclear 304 austenitic stainless steel under conditions: deformation temperature 950―1200℃; deformations 30% and 50%; deformation rates 0.01 and 0.1 s?1. The results show that the flow stress decreases with temperature rise under the same strain rate and deformation, that the flow stress increases with deformation under the same temperature and strain rate, and that the flow stress increases with strain rate under the same temperature condition, i.e., work hardening becomes distinct. Materials exhibit better strength-toughness when the strain rate is 0.01 s-1, the deformation is 50%, and the temperature is 1050℃. | LIU Jie FAN GuangWei HAN PeiDe LIU JianSheng GE DongSheng QIAO GuanJun | 2009 | Science China(Technological Sciences)2009，52，8： | 4 |
| 10 | Scientific literature addressing brain glioma in the Web of Science A 10-year bibliometric analysis显示文摘Brain glioma is a hot topic in recent years; however, brain glioma remains poorly understood. A bibliometric analysis based on the Science Citation Index (SCI) published by the Institute of Scientific Information (ISI) was performed to identify the global research and to improve the understanding of research trends in the brain glioma field from 2001 to 2010. During 2001 to 2010, there were 8 413 papers addressing brain glioma added to the SCI, and this trend is increasing annually. Of these reports, 6 945 papers are written in English. Journals published in the United States had the most papers, including ten core source titles. The Journal of Neuro-Oncology published the most articles followed by Cancer Research. Furthermore, the University of California, San Francisco, is the most productive institution for publishing articles in the brain glioma field. Finally, this study highlights the topics in brain glioma research that are being published around the world. | Zaihua Xu Tao Tang Dongsheng Pan Di Fan Zhenquan Song Hongli Xue | 2011 | Neural Regeneration Research2011，6，32： | 3 |
| 11 | Diagnosis and clinical manifestations of subacute combined degeneration of the spinal cord: Analysis of 21 cases显示文摘BACKGROUND: Subacute combined degeneration of the spinal cord is caused by vitamin B12 deficiency and is a kind of degenerative disease owing the characteristics of nervous system diseases. In addition, different patients have variously clinical manifestations and various prognoses after vitamin B12 therapy. OBJECTIVE: To investigate and analyze diagnosis, clinical manifestations and prognosis of subacute combined degeneration of the spinal cord. DESIGN: Case analysis. SETTING: Department of Neurology, the Third Hospital of Peking University. PARTICIPANTS: A total of 21 subacute combined degeneration of the spinal cord patients including 14 males and 7 females aged from 33 to 82 years were selected from Department of Neurology, the Third Hospital of Peking University from January 1999 to December 2005. Duration from onset to final diagnosis lasted for 1.5–108 months. All patients had typically clinical manifestations; meanwhile, level of serum vitamin B12 was decreased and/or vitamin B12 therapy was effective. All patients provided the confirmed consent. METHODS: Clinical data of 21 subacute combined degeneration of the spinal cord patients were retrospectively analyzed, while general data and clinical characteristics were recorded at the same time. Levels of blood routine, serum vitamin B12 and homocysteine were measured at the phase of hospitalization. Normal value of serum vitamin B12 was 187–1 059 ng/L and normal value of serum homocysteine was 5– 15 μmol/L. All patients received neuroelectrophysiological examination and 15 patients received MRI examinations of spinal cord. After final diagnosis, patients were given vitamin B12 therapy. And follow-up was performed to investigate the prognosis. MAIN OUTCOME MEASURES: ① Levels of blood routine, serum vitamin B12 and homocysteine; ② results of neuroelectrophysiological examination; ③ results of MRI examination of spinal cord; ④ prognosis. RESULTS: Clinical data of 21 patients and follow-up data of 20 patients were involved in the final analysis and 1 patient was lost because of living in the other province. ① Clinical manifestations: All 21 patients had typically clinical manifestations. The original symptoms included numbness of lower and/or upper limbs (5 cases), unstable gait (3 cases), limb asthenia (4 cases), limb numbness combined with light asthenia (5 cases), limb numbness combined with unskillful activity (3 cases), and limb numbness combined with unstable gait (1 case). ② Experimental results: Eight subacute combined degeneration of the spinal cord patients accompanied with mild-severe anemia and mean corpuscular volume of 13 patients were increased. Among 13 subacute combined degeneration of the spinal cord patients not administrating vitamin B12 before hospitalization, the levels of serum vitamin B12 of 2 patients were not measured but those of other patients were decreased. After vitamin B12 therapy,the levels of serum vitamin B12 of 8 patients were normal or increased. In addition, the levels of serum homocysteine of 6 patients were not measured but those of 7 patients were increased. While, the levels of homocysteine of 5 following-up patients were normal. The levels of serum vitamin B12 of 8 patients who received with vitamin B12 therapy before hospitalization were normal or increased. Among them,the levels of homocysteine were not measured in 4 patients, those of 3 patients were increased, and that of 1 patient was normal. ③ Results of neuroelectrophysiological examination: Among all patients, 95% (20/21) patients had abnormal sensory-evoked potential, 89% (8/9) patients had abnormal motor evoked potential, 67% (10/15) patients had abnormal nerve conduction, 13% (2/15) patients had neurogenic muscle injury showed by electromyography (EMG), 70% (7/10) patients had abnormal brain-stem auditory evoked potential, and 40% (4/10) patients had abnormal visual evokedpotential. ④ Results of MRI examination of spinal cord: MRI examination demonstrated that 40% (6/15) patients had spinal cord lesion, but spinal cord lesion disappeared in 2 patients during follow up. In addition, clinical manifestations of patients were improved after standard vitamin B12 therapy. CONCLUSION: Nervous system lesion caused by vitamin B12 deficiency is not only involved in spinal cord, also in peripheral nerve, optic nerve, auditory pathway, etc. Diagnosis of the lesion depends on clinical characteristics and level of serum vitamin B12. Especially, neuroelectrophysiological examination, measurement of homocysteine and MRI examination of spinal cord are beneficial for diagnosis and evaluation of therapeutic effects. | Yanhong Shou Caifeng Li Dongsheng Fan Yang Shen Jun Zhang Weizhong Xiao Shuqing Zhao Jinsheng Liu Wei Sui | 2007 | Neural Regeneration Research2007，2，2： | 3 |
| 12 | Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling显示文摘The link of hedgehog (Hh) signaling activation to human cancer and synthesis of a variety of Hh signaling inhibitors raise great expectation that inhibiting Hh signaling may be effective in human cancer treatment. Cyclopamine (Cyc), an alkaloid from the Veratrum plant, is a specific natural product inhibitor of the Hh pathway that acts by targeting smoothened (SMO) protein. However, its poor solubility, acid sensitivity, and weak potency relative to other Hh antagonists prevent the clinical development of Cyc as a therapeutic agent. Here, we report properties of cyclopamine tartrate salt (CycT) and its activities in Hh signaling-mediated cancer in vitro and in vivo. Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT had a higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC50 = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). We also tested the antitumor effectiveness of these Hh inhibitors using two mouse models of basal cell carcinomas (K14cre:Ptch1neo/neo and K14cre:SmoM2YFP). After topical application of CycT or Cyc daily for 21 days, we found that all CycT-treated mice had tumor shrinkage and decreased expression of Hh target genes. Taken together, we found that CycT is an effective inhibitor of Hh signaling-mediated carcinogenesis. | Qipeng Fan Dongsheng Gu Miao He Hailan Liu Tao Sheng Guorui Xie Ching-xin Li Xiaoli Zhang Brandon Wainwright Arash Garrossian Massoud Garrossian Dale Gardner Jingwu Xie | 2011 | Chinese Journal of Cancer2011，30，7： | 3 |
| 13 | Adenosine monophosphate-activated protein kinase activation enhances embryonic neural stem cell apoptosis in a mouse model of amyotrophic lateral sclerosis显示文摘Alterations in embryonic neural stem cells play crucial roles in the pathogenesis of amyotrophic lateral sclerosis. We hypothesized that embryonic neural stem cells from SOD1G93 A individuals might be more susceptible to oxidative injury, resulting in a propensity for neurodegeneration at later stages. In this study, embryonic neural stem cells obtained from human superoxide dismutase 1 mutant(SOD1G93A) and wild-type(SOD1WT) mouse models were exposed to H2O2. We assayed cell viability with mitochondrial succinic dehydrogenase colorimetric reagent, and measured cell apoptosis by flow cytometry. Moreover, we evaluated the expression of the adenosine monophosphate-activated protein kinase(AMPK) α-subunit, paired box 3(Pax3) protein, and p53 in western blot analyses. Compared with SOD1 WT cells, SOD1G93 A embryonic neural stem cells were more likely to undergo H2O2-induced apoptosis. Phosphorylation of AMPKα in SOD1G93 A cells was higher than that in SOD1 WT cells. Pax3 expression was inversely correlated with the phosphorylation levels of AMPKα. p53 protein levels were also correlated with AMPKαphosphorylation levels. Compound C, an inhibitor of AMPKα, attenuated the effects of H2O2. These results suggest that embryonic neural stem cells from SOD1G93 A mice are more susceptible to apoptosis in the presence of oxidative stress compared with those from wild-type controls, and the effects are mainly mediated by Pax3 and p53 in the AMPKα pathway. | Yanling Sui Zichun Zhao Rong Liu Bin Cai Dongsheng Fan | 2014 | Neural Regeneration Research2014，9，19： | 3 |
| 14 | Suitable layout of gate roads related to slice mining in an ultra-thick unstable coal seam显示文摘We determined a suitable gate road layout in slice mining in an ultra-thick unstable coal seam,using theoretical analysis and numerical calculations.Based on plasticity theory in terms of limiting equilibrium,the width of chain pillar in the upper slice was calculated to be 18 m.The stress distribution in the chain pillar after the upper slice was mined out was described with numerical simulation.The extent of the effect of stress on the upper chain pillar on the lower solid coal was obtained on the basis of an elastic solution of a distributed force loaded on a half-plane.Three layout designs for lower gate roads were proposed and a stability factor was introduced to analyze the stability of the lower pillar with numerical calculation.Gate road translation was determined as the most suitable layout method,which maximizes the extraction rate on the basis of the pillar stability. | Fan Gangwei Zhang Dongsheng Zhou Lei | 2011 | Mining Science and Technology2011，21，4： | 2 |
| 15 | Enhanced Answer Selection in CQA Using Multi-Dimensional Features Combination显示文摘Community Question Answering(CQA) in web forums, as a classic forum for user communication,provides a large number of high-quality useful answers in comparison with traditional question answering.Development of methods to get good, honest answers according to user questions is a challenging task in natural language processing. Many answers are not associated with the actual problem or shift the subjects,and this usually occurs in relatively long answers. In this paper, we enhance answer selection in CQA using multidimensional feature combination and similarity order. We make full use of the information in answers to questions to determine the similarity between questions and answers, and use the text-based description of the answer to determine whether it is a reasonable one. Our work includes two subtasks:(a) classifying answers as good, bad, or potentially associated with a question, and(b) answering YES/NO based on a list of all answers to a question. The experimental results show that our approach is significantly more efficient than the baseline model, and its overall ranking is relatively high in comparison with that of other models. | Hongjie Fan Zhiyi Ma Hongqiang Li Dongsheng Wang Junfei Liu | 2019 | Tsinghua Science and Technology2019，24，3： | 2 |
| 16 | Dynamic evolution characteristics of mining-induced fractures in overlying strata detected by radon显示文摘<正>For environment protection in mining areas in northwest China,we developed a CTSRM(comprehensive test system by radon measurement) to measure radon radioactivity and detect dynamic evolution characteristics of mining-induced fractures in overlying strata.It was used to simulate the relationship between the dynamic evolution characteristics and radon concentrations of 33201~# coalface at Bulianta coal mine in Inner Mongolia,and feasibility of the method was validate. | ZHANG Wei ZHANG Dongsheng MA Liqiang WANG Xufeng FAN Gangwei | 2011 | Nuclear Science and Techniques2011，22，6： | 2 |
| 17 | Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium显示文摘 | Dongsheng Zhang Guo-Chang Fan Xiaoyang Zhou Tiemin Zhao Zeeshan Pasha Meifeng Xu Yi Zhu Muhammad Ashraf Yigang Wang | 2007 | Journal of Molecular and Cellular Cardiology2007，，2： | 1 |
| 18 | Brassinosteroid and gibberellin coordinate rice seed germination and embryo growth by regulating glutelin mobilization显示文摘Seed germination is the beginning of a new lifecycle,and involves many complex physiological and biochemical reactions including seed reserve mobilization in the endosperm and nutrient transport and reuse in the embryo.Although glutelin is a dominant storage protein in rice,its contribution to seed germination and its regulatory mechanisms are mostly unknown.Gibberellin (GA) and brassinosteroid (BR),two major growth-promoting phytohormones,also play positive roles in controlling seed germination.However,how GA and BR interact and coordinate seed germination and facilitate glutelin mobilization remains unclear.In the present study,biochemical and physiological analyses of seed germination indicated that both GA and BR promote seed germination and post-germination growth.Exogenous application of GA restored germination defects caused by BR deficiency or insensitivity.Proteomic and q RT-PCR results showed that the expression of several glutelin proteins and their encoding genes was induced by BR and GA in the embryo.Expression assays suggested that the increased accumulation of glutelin protein in the embryo was due to the accelerated degradation of glutelin by a cysteine proteinase (REP-1) in the endosperm.The breakdown of glutelin in the endosperm showed a strict positive correspondence with the length of the shoot.The GluA2 mutation led to reduced degradation rate of glutelin and defects in seed germination,and the promotion effect of GA on seed germination was weakened in the glua2mutant.In vitro culture assay of rice embryos showed that glutelin mobilization functioned downstream of the GA and BR pathways to promote shoot elongation.These findings suggest a mechanism that mediates crosstalk between BR and GA in co-regulating rice seed germination and embryo growth. | Min Xiong Lingyi Chu Qianfeng Li Jiawen Yu Yihao Yang Peng Zhou Yong Zhou Changquan Zhang Xiaolei Fan Dongsheng Zhao Changjie Yan Qiaoquan Liu | 2021 | The Crop Journal2021，9，5： | 1 |
| 19 | LRIG1 combined with cisplatin enhances bladder cancer lesions via anovel pathway显示文摘 | Fan Li Weimin Yang Dongsheng Guo Zhiquan Hu Hua Xu Zhangqun Ye | 2011 | Oncology Reports2011，，6： | 1 |
| 20 | Anti-inflammatory, antiviral and quantitative study of quercetin-3-O- β -D-glucuronide in Polygonum perfoliatum L.显示文摘 | Dongsheng Fan Xin Zhou Chao Zhao Huaguo Chen Yang Zhao Xiaojian Gong | 2011 | Fitoterapia2011，，6： | 1 |
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