|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | Update in management of mesenteric ischemia显示文摘肠系膜局部缺血混乱被剥夺一或几个腹的机关遇见新陈代谢的要求足够的呼吸的一个发行量不足事件猛抛。尽管 mes 伤寒局部缺血不经常发生,死亡率从 60% ~ 100% ,依靠阻塞的消息提供者。成功的结果依赖于怀疑和迅速的管理的一个高索引。我们简短考察病理生理学和演讲各种各样是化学家实体并且在诊断和治疗考察当前的现状。尽管有在诊断和治疗的进展,迅速的诊断和支持的照顾为成功的结果仍然保持批评。新成像技术,血管内治疗和新兴的研究可以改进我们的途径到这个致命的条件。 | Robert W Chang John B Chang Walter E Longo | 2006 | World Journal of Gastroenterology2006，12，20： | 38 |
| 3 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 4 | 血管周围脂肪组织中的Bmal1通过血管紧张素原转录调控管理静息期血压显示文摘血管周围脂肪组织(perivascular adipose tissue,PVAT)围绕血管,构成了在生理条件下保持血管张力所需的脉管系统的独特的功能整体层。然而,关于PVAT与血压调节之间的关系的资料很少,包括其对昼夜血压变化的潜在作用。 | Chang L Xiong W Zhao X Fan Y Guo Y Garcia-Barrio M Zhang J Jiang Z Lin JD Chen YE 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，2： | 23 |
| 5 | Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels显示文摘 | Fu H Li W Lao Y Luo J Lee NT Kan KK Tsang HW Tsim KW Pang Y Li Z Chang DC Li M Han Y | 2006 | 中国生物学文摘2006，20，10： | 10 |
| 6 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 7 | 胃肠道恶性神经外胚层肿瘤:19例临床病理、免疫组化和分子分析显示文摘胃肠道恶性神经外胚层肿瘤临床非常罕见,目前对其具体发病机制尚不清楚。该文旨在分析胃肠道恶性神经外胚层肿瘤的临床病理特征、治疗及预后。该文收集19例胃肠道恶性神经外胚层肿瘤患者,平均肿瘤直径为4.2 cm。肿瘤最常见的原发部位为小肠(57.9%),其次为胃(15.8%)、结肠(10.5%)、回盲部(5.3%)、食管下端(5.3%)和肛管(5.3%)。 | Chang B Yu L Guo W W 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，1： | 5 |
| 8 | 婴幼儿血管瘤的位置是消退后体积后遗症的预测因子显示文摘尽管婴幼儿血管瘤(IH)能够自行消退,但有些血管瘤的体积后遗症比其他的更多。确定这种后遗症的预测因子将为IH病变提供治疗参考,并有助于获得有利的疗效。本研究旨在探讨IH消退后剩余的体积残留与其位置之间的相关性,并确定其他潜在的结果预测因子。回顾2008-2011年治疗的所有IH患者,通过比较随访照片和最大尺寸病变的照片,获得消退后的体积残留程度和后遗症的量化指标。发现对于初次就诊的儿童,面部周围区域的病变比面部中央(P<0.0001)和胸部区域(P=0.0002)的病变消退更加显著。初次就诊年龄和病变类型一致时,面部周围病变的美学评分显著高于面部中央区域(P<0.0001)、胸部(P<0.0001)和躯干/四肢(P=0.0226)。本研究表明,初次就诊时的病变部位和年龄是造成体积后遗症和复发后病变美学的因素。本研究的结果为指导治疗决策提供了参考。 | 赵泽亮 Chang SJ Yu W Gu Y | 2019 | 中国口腔颌面外科杂志2019，17，3： | 4 |
| 9 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 10 | Projection of the Zhujiang(Pearl) River Delta's potential submerged area due to sea level rise during the 21st century based on CMIP5 simulations显示文摘Projections of potential submerged area due to sea level rise are helpful for improving understanding of the influence of ongoing global warming on coastal areas. The Ensemble Empirical Mode Decomposition method is used to adaptively decompose the sea level time series in order to extract the secular trend component. Then the linear relationship between the global mean sea level(GMSL) change and the Zhujiang(Pearl) River Delta(PRD)sea level change is calculated: an increase of 1.0 m in the GMSL corresponds to a 1.3 m(uncertainty interval from1.25 to 1.46 m) increase in the PRD. Based on this relationship and the GMSL rise projected by the Coupled Model Intercomparison Project Phase 5 under three greenhouse gas emission scenarios(representative concentration pathways, or RCPs, from low to high emission scenarios RCP2.6, RCP4.5, and RCP8.5), the PRD sea level is calculated and projected for the period 2006–2100. By around the year 2050, the PRD sea level will rise 0.29(0.21 to 0.40) m under RCP2.6, 0.31(0.22 to 0.42) m under RCP4.5, and 0.34(0.25 to 0.46) m under RCP8.5, respectively.By 2100, it will rise 0.59(0.36 to 0.88) m, 0.71(0.47 to 1.02) m, and 1.0(0.68 to 1.41) m, respectively. In addition,considering the extreme value of relative sea level due to land subsidence(i.e., 0.20 m) and that obtained from intermonthly variability(i.e., 0.33 m), the PRD sea level will rise 1.94 m by the year 2100 under the RCP8.5scenario with the upper uncertainty level(i.e., 1.41 m). Accordingly, the potential submerged area is 8.57×103 km2 for the PRD, about 1.3 times its present area. | XIA Jiangjiang YAN Zhongwei ZHOU Wen FONG Soi Kun LEONG Ka Cheng TANG Iu Man CHANG S W LEONG W K JIN Shaofei | 2015 | Acta Oceanologica Sinica2015，34，9： | 3 |
| 11 | Attitudes towards acceptance of an innovative home-based and remote sensing rehabilitation protocol among cardiovascular patients in Shantou, China显示文摘BackgroundCardiac 康复(CR ) 协议有对多样化作为基于医院或基于中心的 CR 的一种选择包括本垒的心脏的电视康复(HBCTR ) 。采用本垒的心脏的电视康复的使用,向如此的电子健康技术的接受估计心脏病患者态度是必要的,特别在如此的技术的知识的中国, deficient.MethodsInterviews 在 Shantou 大学医学院的首先隶属于的医院里被进行, Shantou,中国。在经皮的冠的 interventional (一种总线标准) 以后外科,病人们完成了 survey.ResultsAmong 150 个病人,仅仅, 13% 曾经听说了 HBCTR。在我们的 HBCTR 节目的介绍以后, 60% 病人愿意参予节目。从我们问询表数据的 multivariate 分析,变老(或:0.92, 95% CI:0.86-0.98;P = 0.007 ) ,普通家庭月刊收入(或:0.13, 95% CI:0.05-0.34;P <0.001 ) ,教育水平(或:0.24, 95% CI:0.10-0.59;P = 0.002 ) 并且 physical 锻练时间(或:0.19, 95% CI:0.06-0.56;P = 0.003 ) 是为 HBCTR 的接受的独立预言者。从为参予的原因,病人们选择了:提高的安全和独立(28.3%) ,自我监视器的能力物理条件日报(25.4%) ,并且有自动并且紧急情况警戒(23.1%) 。推理因为拒绝:太拖累的操作(34.3%) 和不必要的协议(19.4%).ConclusionsMost 病人关于 HBCTR 缺乏知识,但是在他们了解了节目以后,自愿参与。几个个人和生活方式因素影响了他们节目的接受。这些显示两个都,技术的改进和节目的更好的理解将提高活跃参予。 | Jia-Ying FANG Ji-Linm LI Zhong-Han LI Duan-Min XU Chang CHEN Bin XIE Helen CHEN William W AU | 2016 | Journal of Geriatric Cardiology2016，13，4： | 3 |
| 12 | Corrosion resistance of tannic acid,d-limonene and nano-ZrO_(2)modified epoxy coatings in acid corrosion environments显示文摘The protection of rusted carbon steel in acid corrosion environments is of great significance for equipment to keep safe operation.In this work,we presented a method to protect the rusted steel by ru st conversion treatment and epoxy coating.Tannic acid was selected as rust conversion agent.Tannic acid,D-limonene and nano-ZrO_(2)were used to improve the corrosion resistance of epoxy coatings.The Raman spectra,Xray diffraction and 3 D confocal images were used to characterize the rust conversion reaction.Ad hesion test showed that the loss of wet adhesion of the optimal coating was relatively low due to the addition of tannic acid,limonene and nano-ZrO(2).The corrosion resistance of five different coatings was investigated by scanning electron microscopy(SEM)and electrochemical analysis.Results show that after 264 h acid immersion,the low frequency resistance of the optimal coating consisting of rust conversion treatment and additives is 10^(7)Ωcm^(2),three orders magnitude higher than that of the pristine coating.Moreover,SEM indicates that the optimal coating possesses a smooth surface and an unbroken interface between substrate and coating.Accordingly,the corrosion-resistant mechanism of the hybrid coating is proposed. | Junwei Chang Zhenyu W ang En-hou Han Xinlei Liang Gang Wang Zuyao Yi Na Li | 2021 | Journal of Materials Science & Technology2021，，6： | 3 |
| 13 | A microcontact and wear model for chemical mechanical polishing of silicon wafer 显示文摘 | Zhao Y W Chang L | 2002 | Wear2002，252，： | 2 |
| 14 | Message oriented discrete event simulation 显示文摘 | Chang W Jones L R | 1994 | Simulation1994，63，2： | 2 |
| 15 | The acute effects of exercise on prolactin and growth hormone secretion: Comparison between sedentary women and women runners with normal and abnormal menstrual cycles 显示文摘 | CHANG F E DODDS W G SULLIVAN M | 1986 | Clin Endocrinol Metab1986，62，： | 2 |
| 16 | Oxidation behavior of diamond-like carbon films 显示文摘 | Wang D Y Chang C L Ho W Y | 1999 | Surface and Coatings Technology1999，120，： | 2 |
| 17 | An examination of herd behavior in equity markets: An international perspective显示文摘 | Eric C Chang Joseph W Cheng Ajay Khorana | 2000 | Journal of Banking and Finance2000，，10： | 2 |
| 18 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 19 | Load forecasting using support vector Machines: a study on EUNITE competition 2001 显示文摘 | Chen B J Chang M W Lin C J | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 20 | Faminial risk of hepatocelluarear cinoma among chronic hepatitis B carriers and their relatives显示文摘 | Yu M W Chang H C LiawYF | 2000 | J Natl Cancer Inst2000，92，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员