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| 1 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 4 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 5 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 6 | Converting ceria polyhedral nanoparticles into single-crystal nanospheres 显示文摘 | Feng X D Sayle D C Wang Z L Paras M S Santora B Sutorik A C Sayle T X T Yang Y Ding Y Wang X D Her Y S | 2006 | Science2006，312，5779： | 1 |
| 7 | Wind-blown origin of the Pliocene red clay formation in the central Loess Plateau 显示文摘 | Ding Z L Sun J M Liu T S Zhu R X Yang S L Guo B | 1998 | Earth and Planetary Science Letters1998，161，： | 1 |
| 8 | Phase regression approach for estimating the parameters of a noisy multi-frequency signal显示文摘 | ZHU L M DING H DING K | 2004 | IEE Proceedings-Vision Image & Signal Processing2004，151，5： | 1 |
| 9 | DNMT3A mutations in acute myeloid leukemia显示文摘 | Ley T J Ding L Walter M J | 2010 | New England Journal of Medicine2010，363，25： | 1 |
| 10 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 11 | Demethylation of microRNA -142 induced by demethylation agents plays a suppressive role in osteosarcoma cells 显示文摘 | Ding M Hu J Ni L | 2015 | Oncol Lett2015，9，5： | 1 |
| 12 | Morphology and water vapor permeability of temperature-sensitive polyu- rethanes显示文摘 | Ding X M Hu J L Tao X M | 2008 | Journal of Applied Polymer Science2008，107，： | 1 |
| 13 | Investigation of mixing/segregation of mixture particles in gas-solid fluidized beds 显示文摘 | LU H L ZHAO Y H DING J M DIMITRI G LI W | 2007 | Chemical Engineering Science2007，62，12： | 1 |
| 14 | Effect of a short CAG (glu tamine) repeat on human androgen receptor function显示文摘 | Ding D Xu L Menon M | 2004 | Prostate2004，58，1： | 1 |
| 15 | Volume image registration by template matching显示文摘 | Ding L Goshtasby A Satter M | 2001 | Image and Vision Computing2001，19，： | 1 |
| 16 | Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginylbeta-hydroxylase expression显示文摘 | Carter J J Tong M Silbermann E Lahousse S A Ding F F Longato L Roper N Wands J R | | 0，，03： | 1 |
| 17 | Spectroscopic studies on the interaction of γ,-cyclodextrin-daunorubicin inclusion complex with herring sperm DNA显示文摘 | XU D L WANG X M DING L S | | 0，，： | 1 |
| 18 | The effect of biofeedback training on patients with functional constipation显示文摘 | Ding M Lin Z Lin L | | 0，，： | 1 |
| 19 | A Full-Discretization Method for Prediction of Milling Stability显示文摘 | Ding Y Zhu L M Zhang X J | 2010 | International Journal of Machine Tools & Manufacture2010，50，5： | 1 |
| 20 | The Influence of Alumina Dopant on the Structural Transformation of Sol-gel-derived Nanocrystalline Titania Powders显示文摘 | Ding X Z Liu L Ma X M | 1994 | Journal of Materials Science Letters1994，13，6： | 1 |
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