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| 1 | Divergent expression of bacterial wall sensing toll-like receptors 2 and 4 in colorectal cancer显示文摘AIM To characterize the expression of toll-like receptors(TLR) 2 and 4 in colorectal cancer(CRC) and in normal colorectal mucosa.METHODS We analysed tissue samples from a prospective series of 118 unselected surgically treated patients with CRC. Sections from formalin fixed, paraffin embedded specimens were analysed for TLR2 and TLR4 expression by immunohistochemistry. Two independent assessors evaluated separately expression at the normal mucosa, at the invasive front and the bulk of the carcinoma, and in the lymph node metastases when present. Expression levels in different locations were compared and their associations with clinicopathological features including TNM-stage and the grade of the tumour and 5-year follow-up observations were analysed.RESULTS Normal colorectal epithelium showed a gradient of expression of both TLR2 and TLR4 with low levels in the crypt bases and high levels in the surface. In CRC, expression of both TLRs was present in all cases and in the major proportion of tumour cells. Compared to normal epithelium, TLR4 expression was significantly weaker but TLR2 expression stronger in carcinoma cells. Weak TLR4 expression in the invasive front was associated with distant metastases and worse cancerspecific survival at 5 years. In tumours of the proximal colon the cancer-specific survival at 5 years was 36.9% better with strong TLR4 expression as compared with those with weak expression(P = 0.044). In contrast, TLR2 expression levels were not associated with prognosis. Tumour cells in the lymph node metastases showed higher TLR4 expression and lower TLR2 expression than cells in primary tumours.CONCLUSION Tumour cells in CRC show downregulation of TLR4 and upregulation of TLR2. Low expression of TLR4 in the invasive front predicts poor prognosis and metastatic disease. | Karoliina Paarnio Sara Vayrynen Kai Klintrup Pasi Ohtonen Markus J Makinen Jyrki Makela Tuomo J Karttunen | 2017 | World Journal of Gastroenterology2017，23，26： | 8 |
| 2 | Crystallographic Analysis of Martensite in 0.2C-2.0Mn-1.5Si-0.6Cr Steel using EBSD显示文摘The crystallography of martensite formed in 0.2C-2.0Mn-1.5Si-0.6Cr steel was studied using the electron backscattered diffraction(EBSD) technique.The results showed that the observed orientation relationship(OR) was closer to that of Nishiyama-Wassermann(N-W) than Kurdjumov-Sachs.The martensite consisted of parallel laths forming morphological packets.Typically,there were three different lath orientations in a morphological packet consisting of three specific N-W OR variants sharing the same {111} austenite plane.A packet of martensite laths with a common {111} austenite plane was termed a crystallographic packet.Generally,the crystallographic packet size corresponded to the morphological packet size,but occasionally the morphological packet was found to consist of two or more crystallographic packets.Therefore,the crystallographic packet size appeared to be finer than the morphological packet size.The relative orientation between the variants in crystallographic packets was found to be near 60 /<110>,which explains the strong peak observed near 60 in the grain boundary misorientation distribution.Martensite also contained a high fraction of boundaries with a misorientation in the range 2.5-8.Typically these boundaries were found to be located inside the martensite laths forming sub-laths. | Pasi P.Suikkanen Cyril Cayron Anthony J.DeArdo L.Pentti Karjalainen | 2011 | Journal of Materials Science & Technology2011，27，10： | 6 |
| 3 | Metallic mineral deposits in the Nordic countries显示文摘 | Paer Weihed Pasi Eilu Rune B. Larsen Henrik Stendal Mikko Tontti | 2008 | Episodes2008，31，1： | 6 |
| 4 | Machine Vision Based Measurement of Dynamic Contact Angles in Microchannel Flows显示文摘When characterizing flows in miniaturized channels, the determination of the dynamic contact angle is important. By measuring the dynamic contact angle, the flow properties of the flowing liquid and the effect of material properties on the flow can be characterized. A machine vision based system to measure the contact angle of front or rear menisci of a moving liquid plug is described in this article. In this research, transparent flow channels fabricated on thermoplastic polymer and sealed with an adhesive tape are used. The transparency of the channels enables image based monitoring and measurement of flow variables, including the dynamic contact angle. It is shown that the dynamic angle can be measured from a liquid flow in a channel using the image based measurement system. An image processing algorithm has been developed in a MATLAB? environment. Im- ages are taken using a CCD camera and the channels are illuminated using a custom made ring light. Two fitting methods, a circle and two parabolas, are experimented and the results are compared in the measurement of the dynamic contact angles. | Valtteri Heiskanen Kalle Marjanen Pasi Kallio | 2008 | Journal of Bionic Engineering2008，5，4： | 5 |
| 5 | CT血管成像斑点征与自发性小脑出血血肿扩大及功能预后的关系显示文摘CT血管成像(CTA)斑点征与自发性幕上脑出血患者的血肿扩大、病死率及功能预后不良有关。但是,尚无相关研究探讨斑点征与自发性小脑出血的关系。为了研究斑点征与自发性小脑出血血肿扩大,90 d病死率及功能预后之间的相关性,研究人员收集了2002至2017年3所教学医院的358例自发性小脑出血患者的相关临床资料(改良Rankin量表评分4~6分定义为功能预后不良)。结果显示,358例自发性小脑出血患者中,有181例(51%)进行了CTA检查。 | 王业青(编译) Singh SD Pasi M Schreuder FHBM | 2021 | 中华医学杂志2021，101，31： | 4 |
| 6 | Faecal microbiota transplantation in patients with Clostridium difficile and significant comorbidities as well as in patients with new indications:A case series显示文摘Fecal microbiota transplantation(FMT) is effective in recurrent Clostridium difficile infection(r CDI). Knowledge of the safety and efficacy of FMT treatment in immune deficient patients is scarce. FMT has been suggested as a potential method for an increasing number of new indications besides r CDI. Among our FMT-treated r CDI patients, we reviewed those with major comorbidities: two human immunodeficiency virus patients, six haemodialysis patients, two kidney transplant patients, two liver transplant patients and a patient with chronic lymphatic leukaemia. We also reviewed those treated with FMT for indications other than r CDI: Salmonella carriage(two patients), trimethylaminuria(two patients), small intestinal bacterial overgrowth(SIBO;one patient), and lymphocytic colitis(one patient), as well as a common variable immunodeficiency patient with chronic norovirus infection and ESBL-producing Escherichia coli(E. coli) carriage. Of the thirteen r CDI patients treated with FMT, eleven cleared the CDI. The observed adverse events were not directly attributable to FMT. Concerning the special indications, both Salmonellas and ESBL-producing E. coli were eradicated. One trimethylaminuria patient and one SIBO-patient reported a reduction of symptoms. Three patients did not experience a benefit from FMT: chronic norovirus, lymphocytic colitis and the other fish malodour syndrome. There were no reported side effects in this group. FMT appeared to be safe and effective for immunocompromised patients with r CDI. FMT showed promise for the eradication of antibiotic-resistant bacteria, but further research is warranted. | Perttu Lahtinen Eero Mattila Veli-Jukka Anttila Jyrki Tillonen Matti Teittinen Pasi Nevalainen Seppo Salminen Reetta Satokari Perttu Arkkila | 2017 | World Journal of Gastroenterology2017，23，39： | 2 |
| 7 | Finite element methods for structural hot spot stress determination—a comparison of procedures显示文摘 | Ilkka Poutiainen Pasi Tanskanen Gary Marquis | 2004 | International Journal of Fatigue2004，，11： | 2 |
| 8 | Humoral Response to Recombinant Hepatitis B Virus Vaccine at Birth: Role of HLA and Beyond显示文摘 | Miryam Martinetti Annalisa De Silvestri Cesare Belloni Annamaria Pasi Carmine Tinelli Angela Pistorio Laura Salvaneschi Giorgio Rondini Maria Antonia Avanzini Mariaclara Cuccia | 2000 | Clinical Immunology2000，，： | 2 |
| 9 | Risk Management: A New Project Management Perspective显示文摘 | Pasis Mselle Jacob Kashiwagi Dean Kashiwagi Aderemi Adeyemi | 2011 | Journal of Civil Engineering and Architecture2011，5，6： | 2 |
| 10 | HIF-1α and VEGF are Associated with Disease Progression in Esophageal Carcinoma显示文摘 | Heikki Takala Juha Saarnio Heikki Wiik Pasi Ohtonen Ylermi Soini | 2011 | Journal of Surgical Research2011，，1： | 2 |
| 11 | Railroad capacity tools and methodologies in the U.S. and Europe显示文摘A growing demand for passenger and freight transportation, combined with limited capital to expand the United States(U.S.) rail infrastructure, is creating pressure for a more efficient use of the current line capacity. This is further exacerbated by the fact that most passenger rail services operate on corridors that are shared with freight traffic. A capacity analysis is one alternative to address the situation and there are various approaches, tools, and methodologies available for application. As the U.S. continues to develop higher speed passenger services with similar characteristics to those in European shared-use lines, understanding the common methods and tools used on both continents grows in relevance. There has not as yet been a detailed investigation as to how each continent approaches capacity analysis, and whether any benefits could be gained from cross-pollination. This paper utilizes more than 50 past capacity studies from the U.S. and Europe to describe the different railroad capacity definitions and approaches, and then categorizes them, based on each approach. The capacity methods are commonly divided into analytical and simulation methods, but this paper also introduces a third, ‘‘combined simulation–analytical'' category. The paper concludes that Europeanrail studies are more unified in terms of capacity, concepts,and techniques, while the U.S. studies represent a greater variation in methods, tools, and objectives. The majority of studies on both continents use either simulation or a combined simulation–analytical approach. However, due to the significant differences between operating philosophy and network characteristics of these two rail systems,European studies tend to use timetable-based simulation tools as opposed to the non-timetable-based tools commonly used in the U.S. rail networks. It was also found that validation of studies against actual operations was not typically completed or was limited to comparisons with a base model. | Hamed Pouryousef Pasi Lautala Thomas White | 2015 | Journal of Modern Transportation2015，23，1： | 2 |
| 12 | Binding of AFBl alters adhesion properties of Laetobaeillus rhamnosis strain GG in a Caeo-model显示文摘 | Pasi kanakanpaa Elina Tuomola Hani EL-nezami | 2000 | Journal of FoodProtection2000，63，3： | 1 |
| 13 | A linguistic modeling of consensus in group decision making based on OWA operators显示文摘 | Bordogna G Fedrizzi M Pasi G | 1997 | IEEE Transactions on Systems Man and Cybernetics1997，27，1： | 1 |
| 14 | Cytokines in depression and heart failure 显示文摘 | Pasie Jagod M D | 2003 | Psychosconm Med2003，65，1： | 1 |
| 15 | An experimental study of the effects of water mist characteristics on pool fire suppression显示文摘 | Meenakshi Gupta Amit Pasi Anjan Ray S.R. Kale | 2013 | Experimental Thermal and Fluid Science2013，，： | 1 |
| 16 | Probiotics:effects on immunity显示文摘 | Yelda Sutas Pasi Kankaanp (aa) Heikki Arvilommi and Seppo Salminen | 2001 | Am J Clin Nutr2001，73，： | 1 |
| 17 | Linguistic Aggregation Operators of Selection Criteria in Fuzzy Information Retrieval 显示文摘 | Bordogna G Pasi G | 1995 | International Journal of Intelligent Systems1995，10，： | 1 |
| 18 | Surface binding of aflatoxin B1 by lactic acid bacteria显示文摘 | CAROLYN A H HANI S E PASI E K | 2001 | Applied and Environmental Microbiology2001，67，7： | 1 |
| 19 | Determination of cytokine responses using a multiplexed fluorescent microsphere immunoassay显示文摘 | Martins T B Pasi B M Pickering J W | 2002 | Am J Clin Pathol2002，118，3： | 1 |
| 20 | Androgen Receptor and Human Therapy Failer of Prostate Cancer显示文摘 | Pasi Koivisoto Meelis Kolmer Tapio Visakerpi etal | 1998 | Am J1998，152，1： | 1 |
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