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| 1 | Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8^(+ ) T lymphocytes in human non-small cell lung cancer显示文摘T-cell tolerance is an important mechanism for tumor escape,but the molecular pathways involved in T-cell tolerance remain poorly understood.It remains unknown whether the inhibitory immunoreceptor programmed death-1(PD-1)plays a role in conditions of human non-small cell lung cancer(NSCLC).In this study,we detected PD-1 expression on CD81 T cells from healthy control peripheral blood mononuclear cells(PBMCs)and the PBMCs of NSCLC patients as well as NSCLC tissues.Results showed that tumor-infiltrating CD81 T cells had increased PD-1 expression and impaired immune function,including reducing cytokine production capability and impairing capacity to proliferate.Blockade of the PD-1/PD-L1 pathway by the PD-L1-specific antibody partially restored cytokine production and cell proliferation.These data provide direct evidence that the PD-1/PD-L1 pathway is involved in CD81 T-cell dysfunction in NSCLC patients.Moreover,blocking this pathway provides a potential therapy target in lung cancer. | Yan Zhang Shengdong Huang Dejun Gong Yanghua Qin Qian Shen | 2010 | Cellular & Molecular Immunology2010，7，5： | 48 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | SNP-based linkage mapping for validation of adult plant stripe rust resistance QTL in common wheat cultivar Chakwal 86显示文摘Wheat crops in China are constantly challenged by stripe rust. Deployment of cultivars with diverse resistances is the best strategy to control the disease. A recombinant inbred line(RIL) population derived from a cross between the resistant cultivar Chakwal 86 and susceptible landrace Mingxian 169 was studied in multiple environments to examine the underlying genetics and to identify quantitative trait loci(QTL) for stripe rust resistance.One hundred and twenty-eight RILs were genotyped with wheat 35 K SNP array and a genome-wide linkage map with 1480 polymorphic SNP markers, or bins, was constructed.Two major QTL on chromosomes 1BL and 3BS, and one minor QTL on 6BS had significant effects in reducing stripe rust severity. The QTL were validated using composite interval mapping(CIM) and inclusive composite interval mapping(ICIM). These methods explained59.0%–74.1% of the phenotype variation in disease response. The QTL on chromosome 1 BL was confirmed to be Yr29/Lr46 and the one on 3BS was the resistance allele identified in CIMMYT germplasm but was not Yr30/Sr2. The QTL on 6BS probably corresponded to previously known QTL. RILs with combined QTL were more resistant than those with single or no QTL. Kompetitive allele-specific PCR(KASP) assays for the QTL with largest effect QTL on chromosome 3BS were performed on a subset of RILs and 150 unrelated wheat lines. The QTL on 3BS with its linked KASP markers can be used in marker-assisted selection to improve stripe rust resistance in breeding programs. | Qingdong Zeng Jianhui Wu Shuo Huang Fengping Yuan Shengjie Liu Qilin Wang Jingmei Mu Shizhou Yu Li Chen Dejun Han Zhensheng Kang | 2019 | The Crop Journal2019，7，2： | 2 |
| 4 | Tracking topological entity changes in 3D collaborative modeling systems显示文摘One of the key problems in collaborative geometric modeling systems is topological entity correspondence when topological structure of geometry models on collaborative sites changes.In this article,we propose a solution for tracking topological entity alterations in 3D collaborative modeling environment.We firstly make a thorough analysis and detailed categorization on the alteration properties and causations for each type of topological entity,namely topological face and topological edge.Based on collaborative topological entity naming mechanism,a data structure called TEST (Topological Entity Structure Tree) is introduced to track the changing history and current state of each topological entity,to embody the relationship among topological entities.Rules and algorithms are presented for identification of topological entities referenced by operations for correct execution and model consistency.The algorithm has been verified within the prototype we have implemented with ACIS. | Cheng Yuan He Fazhi Huang Zhiyong Cai Xiantao Zhang Dejun | 2012 | Computer Aided Drafting,Design and Manufacturing2012，22，1： | 2 |
| 5 | Spectroscopic studies of interfacial structures of CeO 2 –TiO 2 mixed oxides显示文摘 | Jun Fang Xinzhen Bi Dejun Si Zhiquan Jiang Weixin Huang | 2007 | Applied Surface Science2007，，22： | 2 |
| 6 | Direct electrochemistry of catalase at amine-functionalized graphene/gold nanoparticlescomposite film for hydrogen peroxide sensor显示文摘 | HUANG Kejing NIU Dejun LIU Xue | 2011 | Electrochimica Acta2011，56，7： | 1 |
| 7 | On-farm evaluation of an in-season nitrogen management strategy based on soil N min test显示文摘 | Zhenling Cui Fusuo Zhang Xinping Chen Yuxin Miao Junliang Li Liwei Shi Jiufei Xu Youliang Ye Chunsheng Liu Zhiping Yang Qiang zhang Shaomin Huang Dejun Bao | 2007 | Field Crops Research2007，，1： | 1 |
| 8 | Long-term toxicity effects of cadmium and lead on Bufo raddei Tadpoles 显示文摘 | Yingmei Z Dejun Huang Dongqin Z | 2007 | Bull Environ Contam Toxicol2007，79，： | 1 |
| 9 | Long- term toxicity effects of cadmium and lead on Bufo raddei tadpoles 显示文摘 | ZHANG Yingmei HUANG Dejun ZHAO Dongqin | 2007 | Bull Environ Contain Toxicol2007，79，2： | 1 |
| 10 | Global DNA hypomethylation, rather than reactive oxygen species (ROS), a potential facilitator of cadmium-stimulated K562 cell proliferation显示文摘 | Dejun Huang Yingmei Zhang Yongmei Qi Che Chen Weihong Ji | 2008 | Toxicology Letters2008，，1： | 1 |
| 11 | An error - model study of a new type of coordinate - measuring machine based on the parallel- link mechanism 显示文摘 | Dejun Liu Rensheng Che Qingchen Huang | 2000 | Measurement Science and Technology2000，，11： | 1 |
| 12 | Spectroscopic studies of interfacial structures of Ce02-TiO2mixed oxides 显示文摘 | Jun Fang Xinzhen Bi Dejun Si Zhiquan Jiang Weixin Huang | 2007 | Applied Surface Science2007，253，22： | 1 |
| 13 | Cadmium induced MTs synthesis via oxidative stress in yeast 显示文摘 | Liu Jianghai Zhang Yingraei Huang Dejun | 2005 | Saccharomyces Cerevisiae Molecular and Cellular Biochemistry2005，280，： | 1 |
| 14 | A measuring model study of a new coordinate-measuring machine based on the parallel kinematic mechanism 显示文摘 | LIU Dejun HUANG Qingcheng CHE Rensheng etal | 1999 | Measurement Science &Technology1999，10，11： | 1 |
| 15 | On-farm evaluation of an in-season nitrogen management strategy based on soil N min test显示文摘 | Zhenling Cui Fusuo Zhang Xinping Chen Yuxin Miao Junliang Li Liwei Shi Jiufei Xu Youliang Ye Chunsheng Liu Zhiping Yang Qiang zhang Shaomin Huang Dejun Bao | 2007 | Field Crops Research2007，，1： | 1 |
| 16 | High-index faceted platinum nanocrystals supportedon carbon black as highly efficient catalysts for ethanolelectrooxidation 显示文摘 | ZHOU Zhiyou HUANG Zhizhong CHEN Dejun etal | 2010 | Angewandte Chemie InternationalEdition2010，49，： | 1 |
| 17 | Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1a显示文摘Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic targets.Various RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes. | Zhou Yang Yingjun Quan Yusheng Chen Yijun Huang Renhong Huang Weiping Yu Dejun Wu Min Ye Zhijun Min Bo Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 18 | An Error-model Study of a New Coordinate-measuring Machaine Based on the Parallel-link Mechanism显示文摘 | Liu Dejun Che Rensheng Huang Qingcheng | 2000 | Measurement Science and Technology2000，11，12： | 1 |
| 19 | Heterosis and polymorphisms of gene expression in an elite rice hybrid as revealed by a microarray analysis of 9198 unique ESTs显示文摘 | Yi Huang Lida Zhang Jianwei Zhang Dejun Yuan Caiguo Xu Xianghua Li Daoxiu Zhou Shiping Wang Qifa Zhang | 2006 | Plant Molecular Biology (-)2006，，4： | 1 |
| 20 | A new type of optical FBG-based scour monitoring sensor 显示文摘 | Huang Liqing Wang Dejun Zhou Zhi | 2007 | Pacific Science Review2007，9，1： | 1 |
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