|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparative evaluation of microscopy,OptiMAL® and 18S rRNA gene based multiplex PCR for detection of Plasmodium falciparum & Plasmodium vivax from field isolates of Bikaner,India显示文摘Objective:To evaluate microscopy,OptiMAL? and multiplex PCR for the identification of Plasmodium falciparum(P.falciparum) and Plasmodium vivax(P.vivax) from the field isolates of Bikaner,Rajasthan(Northwest India).Methods:In this study,a multiplex PCR(P.falciparum and P.vivax) was further developed with the incorporation of Plasmodium malariae(P.malariae) specific primer and also a positive control.The performance of microscopy,plasmodium lactate dehydrogenase(pLDH) based malaria rapid diagnostic test OptiMAL? and 18S rRNA gene based multiplex PCR for the diagnosis of P.falciparum and P.vivax was compared.Results:The three species multiplex PCR if.falciparum,P.vivax and P.malariae) with an inbuilt positive control was developed and evaluated.In comparison with multiplex PCR,which showed the sensitivity and specificity of 99.36%(95%CI,98.11%-100.00%) and 100.00%(95%CI,100.00%-100.00%),the sensitivity and specificity of microscopy was 90.44%(95%CI,88.849-95.04%) and 99.22%(95% CI,97.71%-100.00%),and OptiMAL? was 93.58%(95%CI,89.75%-97.42%) and 97.69%(95%CI, 95.10%-100.00%).The efficiencies were 99.65%,95.10%and 95.45%for multiplex PCK.microscopy and OptiMAL?.respectively.Conclusions:Our results raise concerns over the overall sensitivities of microscopy and OptiMAL?,when compared to the multiplex PCR and thus stress the need for new molecular interventions in the accurate detection of the malarial parasites.This further highlights the fact that further developments are needed to improve the performance of rapid diagnostic tests at field level. | Deepak Pakalapati Shilpi Garg Sheetal Middha Abhishek Kochar Amit Kumar Subudhi Boopathi Pon Arunachalam Sanjay Kumar Kochar Vishal Saxena Pareek RP Jyoti Acharya Dhanpat Kumar Kochar Ashis Das | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，5： | 3 |
| 2 | Urbanization and Its Im- pact on Groundwater: A Remote Sensing and GIS-based Assess- ment Approach显示文摘 | Mahesh K J Deepak K Garg P K | 2009 | Environmentalist2009，29，1： | 1 |
| 3 | Jejunal Gallstone Ileus: An Unusual Site of Gallstone Impaction显示文摘 | Mandeep Kumar Garg Ram Prakash Galwa Deepak Goyal N. Khandelwal | 2009 | Journal of Gastrointestinal Surgery2009，，4： | 1 |
| 4 | Monitoring and modeling of urban sprawl using remote sensing and GIS techniques显示文摘 | MAHESH K J GARG P K DEEPAK K | | 0，，01： | 1 |
| 5 | Random Web surfer PageRank algorithm显示文摘 | Navadiya Hareshkumar Deepak Garg | 2012 | International Journal of Computer Aplications2012，35，11： | 1 |
| 6 | Spectrum of heart disease associated with murine and human GATA4 mutation显示文摘 | Satish K. Rajagopal Qing Ma Dita Obler Jie Shen Ani Manichaikul Aoy Tomita-Mitchell Kari Boardman Christine Briggs Vidu Garg Deepak Srivastava Elizabeth Goldmuntz Karl W. Broman D. Woodrow Benson Leslie B. Smoot William T. Pu | 2007 | Journal of Molecular and Cellular Cardiology2007，，： | 1 |
| 7 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Naveen Garg Satendra Tewari Aditya Kapoor Deepak Kumar Gupta Nakul Sinha | 2000 | International Journal of Cardiology2000，，1： | 1 |
| 8 | Optimization studies of blend composition and ageing parameters for making LDPE/HDPE/LLDPE films by response surface methodology显示文摘 | Deepak Srivastava R Garg P Kumar | 2000 | Macromolecular Materials and Engineering2000，283，1： | 1 |
| 9 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Naveen Garg Satendra Tewari Aditya Kapoor Deepak Kumar Gupta Nakul Sinha | 2000 | International Journal of Cardiology2000，，1： | 1 |
| 10 | Analgesic, anti-inflammatory, antipyretic and toxicological evaluation of some newer 3-methyl pyrazolone derivatives显示文摘 | G. Mariappan B.P. Saha L. Sutharson Ankit Singh S. Garg L. Pandey Deepak Kumar | 2011 | Saudi Pharmaceutical Journal2011，，2： | 1 |
| 11 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) 2014显示文摘 | Shiv Kumar Sarin Chandan Kumar Kedarisetty Zaigham Abbas Deepak Amarapurkar Chhagan Bihari Albert C. Chan Yogesh Kumar Chawla A. Kadir Dokmeci Hitendra Garg Hasmik Ghazinyan Saeed Hamid Dong Joon Kim Piyawat Komolmit Suman Lata Guan Huei Lee Laurentius A. | 2014 | Hepatology International2014，，4： | 1 |
| 12 | Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems显示文摘 | Vivek K. Pawar Shaswat Kansal Garima Garg Rajendra Awasthi Deepak Singodia Giriraj T. Kulkarni | 2011 | Drug Delivery2011，，2： | 1 |
| 13 | Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease显示文摘The mammalian target of rapamycin(mTOR)is a protein kinase that controls cellular metabolism,catabolism,immune responses,autophagy,survival,proliferation,and migration,to maintain cellular homeostasis.The mTOR signaling cascade consists of two distinct multi-subunit complexes named mTOR complex 1/2(mTORC1/2).mTOR catalyzes the phosphorylation of several critical proteins like AKT,protein kinase C,insulin growth factor receptor(IGF-1R),4E binding protein 1(4E-BP1),ribosomal protein S6 kinase(S6K),transcription factor EB(TFEB),sterol-responsive element-binding proteins(SREBPs),Lipin-1,and Unc-51-like autophagy-activating kinases.mTOR signaling plays a central role in regulating translation,lipid synthesis,nucleotide synthesis,biogenesis of lysosomes,nutrient sensing,and growth factor signaling.The emerging pieces of evidence have revealed that the constitutive activation of the mTOR pathway due to mutations/amplification/deletion in either mTOR and its complexes(mTORC1 and mTORC2)or upstream targets is responsible for aging,neurological diseases,and human malignancies.Here,we provide the detailed structure of mTOR,its complexes,and the comprehensive role of upstream regulators,as well as downstream effectors of mTOR signaling cascades in the metabolism,biogenesis of biomolecules,immune responses,and autophagy.Additionally,we summarize the potential of long noncoding RNAs(lncRNAs)as an important modulator of mTOR signaling.Importantly,we have highlighted the potential of mTOR signaling in aging,neurological disorders,human cancers,cancer stem cells,and drug resistance.Here,we discuss the developments for the therapeutic targeting of mTOR signaling with improved anticancer efficacy for the benefit of cancer patients in clinics. | Vivek Panwar Aishwarya Singh Manini Bhatt Rajiv K.Tonk Shavkatjon Azizov Agha Saquib Raza Shinjinee Sengupta Deepak Kumar Manoj Garg | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 14 | Publish/subscribe based information dissemination over VANET utilizing DHT显示文摘一个车辆的特定的网络(VANET ) 能作为以一种异步、自治的方式交流的动人的车辆的一个网络被设想。在 VANET 应用程序的有效、可伸缩的信息传播由于在网络拓扑学引起无法预言的变化的车辆的运动是主要挑战。publish/ 订阅通讯范例及时提供去耦,在传达实体之间的空间,和同步,和礼品本身作为为 VANET 的信息传播的一个漂亮解决方案喜欢环境。在这份报纸,我们为利用的信息传播建议我们的途径出版 / 订阅并且分布式的哈希值桌子(DHT ) 基于覆盖网络。在我们的途径,我们假定由静止信息车站和动人的车辆组成的混合 VANET。这些信息车站在城市的每主要交叉被安装,车辆能起出版商,订户,或经纪人取决于上下文的作用。信息车站形式 DHT 为相关出版物和订阅作为约会点在自己和行为之中基于经纪人覆盖。进一步,信息车站也在定位订阅了信息项目的车辆帮助。我们与对方一起关于信息车站和他们的物理连接的数字考虑这混合 VANET 的不同可能的推广。我们执行收到的 2011 年 8 月 22 日;接受 2012 年 1 月 21 日电子邮件:tulika_mishra@rediffmail.com 模拟将在这些不同推广情形估计我们的途径的表演并且在城市、半城市的区域讨论他们的适用性。 | Tulika PANDEY Deepak GARG Manoj Madhav GORE | 2012 | Frontiers of Computer Science2012，6，6： | 0 |
| 15 | Unusual presentation of extramedullary blast crisis in chronic myeloid leukemia:A case report显示文摘BACKGROUND Extramedullary blast crisis in chronic myeloid leukemia(CML)is an uncommon occurrence of leukemic blast infiltration in regions other than the bone marrow.Malignant infiltration of the serosal membranes should be considered in cases where CML presents with ascites or pleural effusion.CASE SUMMARY A 23-year-old female with CML presented with progressively worsening ascites and pleural effusion despite first-line tyrosine kinase inhibitor treatment.Her blood work indicated leukocytosis with myelocyte bulge and 2%blasts.Analysis of the patient’s bone marrow confirmed the chronic phase of CML.Abdominal ultrasound revealed hepatosplenomegaly with ascites.The fluid investigation of both ascites and pleural effusion revealed a predominance of neutrophils with exudate.However,no acid-fast bacilli or growth was observed after culturing.Although hydroxyurea reduced cell counts,there was no observed effect on ascites or pleural effusion.Repeat investigation of the ascitic and pleural fluid revealed a polymorphous myeloid cell population consisting of myelocytes,metamyelocytes,band forms,neutrophils and a few myeloblasts.Extramedullary blast crisis was suspected,and mutation analysis was performed.We switched the patient to dasatinib.The patient’s symptoms were relieved,and ascites and pleural effusion diminished.CONCLUSION Serosal membrane involvement in CML is extremely rare.In this case,the patient responded well to dasatinib treatment. | Rashmi Mishra Sandeep Garg Praveen Bharti Deepak Ranjan Malla Ishan Rohatgi Sachin Gautam | 2023 | World Journal of Hematology2023，10，4： | 0 |
| 16 | Design of Energy Efficient WSN Using a Noble SMOWA Algorithm显示文摘In this paper,the establishment of efficientWireless Sensor Network(WSN)networks has been projected to minimize the consumption of energy using a new Self-adaptive Multi-Objective Weighted Approach(SMOWA)algorithm for solving a multi-objective problem.The Different WSN nodes deployment policies have been proposed and applied in this paper to design an efficientWireless Sensor Network to minimize energy consumption.After that,the cluster head for each cluster has been selected with the help of the duty cycle.After configuring the WSN networks,the SMOWA algorithms have been developed to obtain the minimum energy consumption for the networks.Energy minimization,as well as the amount of day-saving,has been calculated for the differentWSNswhich has been configured through different deployment policies.The major finding of the research paper is to improve the durability of Wireless Sensor Network(i)applying different deployment strategies:(Random,S pattern and nautilus shell pattern),and(ii)using a new Meta-heuristic algorithm(SMOWA Algorithm).In this research,the lifetime of WSN has been increased to a significant level.To choose the best result set from all the obtained results set some constraints such as“equivalent distribution”,“number of repetitions”,“maximum amount energy storage by a node”has been set to an allowable range. | Avishek Banerjee Deepak Garg Victor Das Laxminarayan Sahoo Ira Nath Vijayakumar Varadarajan Ketan Kotecha | 2022 | Computers, Materials & Continua2022，，8： | 0 |
| 17 | Real-world five-year outcomes of FlexyRap®cobalt-chromium rapamycin-eluting stents with biodegradable polymer in patients with de-novo coronary artery disease显示文摘BACKGROUND The use of biodegradable polymer drug-eluting stents(BP-DES)has been proven to minimize restenosis and stent thrombosis.The current post-marketing monitoring was observed at the 5-year clinical outcomes of individuals who had been treated with FlexyRap®DES in the real world.AIM To assess the safety and effectiveness of FlexyRap®DES at the 5-year follow-up in real-world settings.METHODS Findings from a retrospective,multi-center,observational,post-market clinical follow-up study of patients treated with FlexyRap®DES for de novo coronary artery disease(CAD)were reported.During the 12-mo follow-up,the primary endpoint was target lesion failure,which was defined as the composite of cardiovascular death, target vessel myocardial infarction(TV-MI), and clinically driven target lesion revascularization.RESULTS The data of 500 patients received with FlexyRap®DES was obtained at the completion of the surveillance timeline of 5-year.After the implantation of FlexyRap®DES,the device success rate was 100%.Adverse events that led to major bleeding,permanent disability,or death were not experienced in the patients.The major adverse cardiac event rate at 12-mo,3-year,and 5-year follow-up was 1(0.2%),0(0%),and 1(0.2%)respectively with 0(0%)cardiovascular death,2(0.4%)TV-MI,and 0(0%)TLR compositely.Furthermore,late stent thrombosis was found in 2(0.4%)patients at the follow-up of 12-mo,very late stent thrombosis was observed in 2 patients(0.4%)at 3-year follow-up.CONCLUSION FlexyRap®DES was proved to be safe and efficacious in real-world patients with de novo CAD,indicating a lowered rate of cardiac events and stent thrombosis at 5-year follow-up. | Nitish Garg Raman Chawla Vivek Tandon Deepak Garg Nilesh Parshottam Preeti Vani Malte Neuss | 2023 | World Journal of Cardiology2023，15，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员