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| 1 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 2 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 3 | Cytokines in Mycoplasma pneumoniae infections显示文摘 | Jun Yang W.Craig Hooper Donald J Phillips Deborah F Talkington | 2003 | Cytokine and Growth Factor Reviews2003，，2： | 2 |
| 4 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 5 | P53 and RPA are sequestered in viral replication centers in the nuclei of cells infected with human cytomegalovirus 显示文摘 | Elizabech A F Deborah H S | 1998 | J Virol1998，72，3： | 1 |
| 6 | Correlation between Ash-Fusion Temperatures and Ternary Equilibrium Phase Diagrams 显示文摘 | Huggins F E Deborah A Kosamck | 1981 | Fuel1981，60，7： | 1 |
| 7 | No Significant Association of 14 Candidate Genes With Schizophrenia in a Large European Ancestry Sample: Implications for Psychiatric Genetics显示文摘 | Sanders Alan R Duan Jubao Levinson Douglas F Shi Jianxin He Deli Hou Cuiping Burrell Gregory J Rice John P Nertney Deborah A Olincy Ann Rozic Pablo Vinogradov Sophia Buccola Nancy G Mowry Bryan J Freedman Robert Amin Farooq Black Donald W | 2008 | The American Journal of Psychiatry2008，，4： | 1 |
| 8 | Mental health during pregnancy : A study comparing asian, caucasian and native hawaiian women 显示文摘 | DEBORAH G LESLIE M LEIGHANN F | 2007 | Maternal and Child Health Journal2007，11，3： | 1 |
| 9 | Real-time reverse transeription-polymerase chain reaction assays for the detection and differentiation of North American swine influenza viruses 显示文摘 | Jurgen A R Kelly M L Deborah F C | 2004 | J Vet Diagn Invest2004，16，： | 1 |
| 10 | Collaborative efforts of nursing students and surgical technology students in the simulation laboratory显示文摘 | Richard F Deborah H | 2010 | Teaching and Learning in Nursing2010，5，2： | 1 |
| 11 | Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen gene显示文摘 | Xu J F Deborah A David A | 2002 | Cancer Epidemiology Biomarkers & Prevention2002，11，6： | 1 |
| 12 | Genetic analysis of pathogenic and nonpathogenic Fusarium oxysporum from tomato plants显示文摘 | Bao J R Deborah R F O'Neill N R | 2002 | Can J Botany2002，80，3： | 1 |
| 13 | 显示文摘 | David M P Lawrence F D Deborah G C | 2004 | J Am Chem Soc2004，126，14： | 1 |
| 14 | The impact of complications on outcomes after resection for esophageal and gastroesophageal junction carcinoma显示文摘 | Nabil P Rizk Peter B Bach Deborah Schrag Manjit S Bains Alan D Turnbull Martin Karpeh Murray F Brennan Valerie W Rusch | 2004 | Journal of the American College of Surgeons2004，，1： | 1 |
| 15 | Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement显示文摘 | David Moher Deborah J Cook Susan Eastwood Ingram Olkin Drummond Rennie Donna F Stroup | 1999 | The Lancet1999，，9193： | 1 |
| 16 | Fabrication of nanoparticle micro-arrays patterned using direct write laser photoreduction 显示文摘 | Deborah L Scott F | 2008 | Applied Surface Science2008，255，5： | 1 |
| 17 | Generation and characterization of cDNA clones from Sarcoptes scabiei varhominis for an expressed sequence tag library:iden- tification of homologues of house dust mite allergens 显示文摘 | Katja F Deborah C H Pearly H | 2003 | Am J Trop Med Hyg2003，68，1： | 1 |
| 18 | Dissolution and Regeneration of Bombyx moil Silk Fibroin Using Ionic Liquids 显示文摘 | Phillips David M Drummy Lawrence F Conrady Deborah G | 2004 | J Am Chem Soc2004，126，14： | 1 |
| 19 | Rapid identification oflaboratory contamination with Mycobacterium tuberculosis usingvariable number tandem repeat analysis显示文摘 | Deborah M Rachael E Richard F | 2001 | J Clin Microbiol2001，39，1： | 1 |
| 20 | Local linear regression for estimating time series data显示文摘 | Quinton J Nottingham Deborah F Cook | 2001 | Computational Statistics & Data Analysis2001，37，： | 1 |
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