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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Pathogen avimlence and plant resistance: a key role for recognition显示文摘 | DeWit P | 1997 | Trends in Plant Science1997，2，12： | 1 |
| 3 | Modified range-Doppler processing for FMCW synthetic apertureradar显示文摘 | DeWit J J M Meta A and Hoogeboom P | 2006 | IEEE Geoscience and Remote Sensing Letters2006，3，1： | 1 |
| 4 | A Survey of Models,Analysis Tools and ComPensation Methods for the Control of Machines with Friction显示文摘 | Armstronghelouvry B Dupont P Dewit C C | 1994 | Automatica1994，30，7： | 1 |
| 5 | Indentification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulvum as β-1,3-glucanse and chitinase显示文摘 | Joosten M H Dewit P J | 1989 | Plant Physiol1989，89，： | 1 |
| 6 | Target volumes in radiotherapy for high-grade malig- nant glioma of the brain 显示文摘 | JANSEN E P M DEWIT L G H VAN HERK M | 2000 | Radiotherapy and Oncolo- gy2000，56，2： | 1 |
| 7 | A Survey of Models, Analysis Tools and Compensation Methods for the Control of Machines with Friction显示文摘 | ARMSTRONG-HELOUVRY B DUPONT P DEWIT C | 1994 | Automatica1994，30，7： | 1 |
| 8 | Breath hydrogen concentration and plasma glucose,insulin and free fatty acid levels after lactose,milk,fresh or heated yogurt ingestion by healthy young adults with or without lactose malabsorption显示文摘 | DEWIT O POCHART P DESJEUX J F | 1988 | Nutr1988，4，： | 1 |
| 9 | Identification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulyam as β-1,3-glucanse and chitinase显示文摘 | Joostem M H Dewit P J | 1989 | Plant Physio11989，89，3： | 1 |
| 10 | Identification of several pathogenesis-related proteins in tomato leaves inoculated with Cladosporium fulvum as 1,3-b-glucanases and chitinases显示文摘 | Dewit P J G M | 1989 | Plant Physiol1989，89，： | 1 |
| 11 | EIS measurements on artificial blisters in organic coatings显示文摘 | VANDER W D H VANWESTING E P M DEWIT J H W | | 0，，： | 1 |
| 12 | The vasoactive intestinal peptide analogue RO25-1553 inhibits the production of TNF and IL-12 by LPS-activated monocytes显示文摘 | Dewit D Gourlet P Amraoui Z | 1998 | Immunol Lett1998，60，1： | 1 |
| 13 | An excess of dietary iodine accelerates the development of a thyroid-associated lymphoid tissue in autoimmune prone BB rats显示文摘 | Moow P DeWit HJ Drexhege HA | 1993 | Clin Immunol Immunopath1993，69，： | 1 |
| 14 | An excess of dietary iodine accelerates the development of a thyroid associated lymphoid tissue in autoimmue prone BB rats显示文摘 | Mooij P Dewit HJ Drexhage HA | 1993 | Clin Immunol Immunopathol1993，69，： | 1 |
| 15 | A new solide state process for chemical modification of PET for crystallization rate enhangcement 显示文摘 | Agarwal U S Dewit G Lemstra P J | 2002 | Polymer2002，43，21： | 1 |
| 16 | A survey of models,analysis tools and compensation methods for the control of machines with friction显示文摘 | Armstrong H B Dupont P Canudas DeWit C | 1994 | Automatica1994，30，7： | 1 |
| 17 | Cladosporium fulvum overcomes Cf-2-mediated resistance by producing truncated AVR2elicitor proteins显示文摘 | LUDERER R TAKKEN F L W DEWIT P J G M | 2002 | Molecular microbiology2002，45，3： | 1 |
| 18 | Ph{rsphorylation of the cabin kinase 2 domain of B-50 ( GAP-43 ) in rat cortical growth cones显示文摘 | Edgar MA Pisanelli P DeWit M | 1997 | J Neurohem1997，69，5： | 1 |
| 19 | A survey of models, analysis tools and compensation methods for the control of machines with friction 显示文摘 | ARMSTRONG B DUPONT P DEWIT C | 1994 | Automatica1994，30，7： | 1 |
| 20 | A survey of models, analysis tools and compensation methods for the control of machines with friction显示文摘 | Armstrong-Helouvry B Dupont P Canudas deWit C | 1994 | Automatica1994，30，7： | 1 |
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