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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | A Survey of Models,Analysis Tools and ComPensation Methods for the Control of Machines with Friction显示文摘 | Armstronghelouvry B Dupont P Dewit C C | 1994 | Automatica1994，30，7： | 1 |
| 3 | Photosynthes is of leaf canopies显示文摘 | DEWIT C T | 1965 | Agricultural Research Report1965，，663： | 1 |
| 4 | An overview of brominated flame retardants in the environment显示文摘 | DEWIT C A | 2002 | Chemosphere2002，46，5： | 1 |
| 5 | A Survey of Models, Analysis Tools and Compensation Methods for the Control of Machines with Friction显示文摘 | ARMSTRONG-HELOUVRY B DUPONT P DEWIT C | 1994 | Automatica1994，30，7： | 1 |
| 6 | Light reletions in plant canopies 显示文摘 | IDSO S B DEWIT C T | 1970 | Applied Optics1970，，9： | 1 |
| 7 | Coherence-tuned interrogation of a remote elliptical-core, dual-mode fiber strain sensor 显示文摘 | Bohnert K DeWit G C Nehring J | 1995 | IEEE Journal of Lightwave Technology1995，13，1： | 1 |
| 8 | An Overview of Brominated Flame Retardants in the Environment显示文摘 | Dewit C A | 2002 | Chemosphere2002，46，： | 1 |
| 9 | Friction models and friction compensation 显示文摘 | Olsson H ~strtim K J deWit C C | 1998 | European Journal of Control1998，4，3： | 1 |
| 10 | Revisiting the LuGre friction model 显示文摘 | Astrtim K J deWit C C | 2008 | IEEE Control Systems Magazine2008，81，4： | 1 |
| 11 | On competition显示文摘 | deWit C T | 1960 | Verslagen van Landbouwkundige Onderzoekingen1960，66，： | 1 |
| 12 | Photosynthesis and nitrogen requirements for seed production by various显示文摘 | Sinclair T R Dewit C T | 1975 | Crops Science1975，189，： | 1 |
| 13 | Photosynthesis and nitrogen requirements for seed production by various显示文摘 | Sinclair T R Dewit C T | 1975 | Crops Science1975，189，： | 1 |
| 14 | A new model for control of systems with friction 显示文摘 | Canudas deWit C Olsson H A strom K J | 1995 | IEEE Transactions on Automatic Control1995，40，3： | 1 |
| 15 | Malignant sdwannoma with a rhabdomyoblastic component,a so called triton tumor, A Clinicopathologic study显示文摘 | Dewit L Albus Lutter C E De Jone A S H | 1986 | Cancer1986，58，： | 1 |
| 16 | A survey of models,analysis tools and compensation methods for the control of machines with friction显示文摘 | Armstrong H B Dupont P Canudas DeWit C | 1994 | Automatica1994，30，7： | 1 |
| 17 | Exponential stabilization of mobile robots with nonholonomic constraints 显示文摘 | DeWIT C C SORDALEN O J | 1992 | IEEE Trans on Automatic Control1992，37，11： | 1 |
| 18 | Photosynthate and nitrogen requirement for seed production by various 显示文摘 | Sinclair T R deWit C T | 1975 | Crop sci1975，18，： | 1 |
| 19 | Catalytic dehydrogenation of reducing sugars in alkaline solution at ambient conditions transfer hydrogenation of fructose显示文摘 | Dewit G De Vlieger J J Kock-van Dalen A C | 1978 | Tetrahedron Letters1978，19，15： | 1 |
| 20 | An overview of brominated flame retardants in the environment显示文摘 | DEWIT C | 2002 | Chemosphere2002，46，5： | 1 |
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