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| 1 | AFP level and histologic differentiation predict the survival of patients with liver transplantation for hepatocellular carcinoma显示文摘BACKGROUND: In liver transplantation or resection for hepatocellular carcinoma (HCC), patient selection depends on morphological features. In patients with HCC, we performed a clinicopathological analysis of risk factors that affected survival after liver transplantation. METHODS: In 389 liver transplantations performed from 2004 to 2010, 102 were for HCC patients. Data were collected retrospectively from the Organ Transplantation Center Database. Variables were as follows: age, gender, preoperative alpha-fetoprotein (AFP) levels, Child-Pugh and MELD scores, prognostic staging criteria (Milan and UCSF), etiology, number of tumors, the largest tumor size, total tumor size, multifocality, intrahepatic portal vein tumor thrombosis, bilobarity, and histological differentiation. RESULTS: One hundred and two patients were evaluated. The 5-year overall survival rate was 56.5%. According to the UCSF criteria, 63% of the patients were within and 37% were beyond UCSF (P=0.03). Ten patients were excluded (one with fibrolamellary HCC and 9 because of early postoperative death without HCC recurrence), and 92 patients were assessed. The mean age of the patients was 56.5±6.9 years. Sixty-two patients underwent living donor liver transplantations. The mean follow-up time was 29.4±22.6 months. Fifteen patients (16.3%) died in the follow-up period due to HCC recurrence. Univariate analysis showed that AFP level, intrahepatic portal vein tumor thrombosis, histologic differentiation and UCSF criteria were significant factors related to survival and tumor recurrence. The 5-year estimated overall survival rate was 62.2% in allpatients. According to the UCSF criteria, and the 5-year overall survival rate was 66.7% within and 52.7% beyond the criteria (P=0.04). Multivariate analysis showed that AFP level and poor differentiation were independent factors. CONCLUSIONS: For proper patient selection in liver trans- plantation for HCC, prognostic criteria related to tumor biology (especially AFP level and histological differentiation) should be considered. Poor differentiation and higher AFP levels are indicators of poor prognosis after liver transplantation. | Onur Yaprak Murat Akyildiz Murat Dayangac Baha Tolga Demirbas Necdet Guler Gulen Bulbul Dogusoy Yildiray Yuzer Yaman Tokat | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 15 |
| 2 | Glasgow coma scale and APACHE-II scores affect the liver transplantation outcomes in patients with acute liver failure显示文摘BACKGROUND:The timing and selection of patients for liver transplantation in acute liver failure are great challenges.This study aimed to investigate the effect of Glasgow coma scale(GCS)and APACHE-II scores on liver transplantation outcomes in patients with acute liver failure.METHOD:A total of 25 patients with acute liver failure were retrospectively analyzed according to age,etiology,time to transplantation,coma scores,complications and mortality.RESULTS:Eighteen patients received transplants from live donors and 7 had cadaveric whole liver transplants.The mean duration of follow-up after liver transplantation was 39.86±40.23 months.Seven patients died within the perioperative period and the 1-,3-,5-year survival rates of the patients were72%,72%and 60%,respectively.The parameters evaluated for the perioperative deaths versus alive were as follows:the mean age of the patients was 33.71 vs 28 years,MELD score was 40 vs32.66,GCS was 5.57 vs 10.16,APACHE-II score was 23 vs 18.11,serum sodium level was 138.57 vs 138.44 mmol/L,mean waiting time before the operation was 12 vs 5.16 days.Low GCS,high APACHE-II score and longer waiting time before the operation(P<0.01)were found as statistically significant factors for perioperative mortality.CONCLUSION:Lower GCS and higher APACHE-II scores are related to poor outcomes in patients with acute liver failure after liver transplantation. | Necdet Guler Omer Unalp Ayse Guler Onur Yaprak Murat Dayangac Murat Sozbilen Murat Akyildiz Yaman Tokat | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 9 |
| 3 | Role of pre-transplant 18F-FDG PET/CT in predicting hepatocellular carcinoma recurrence after liver transplantation显示文摘The last two decades have seen a paradigm shift in the selection of patients with hepatocellular carcinoma(HCC)for liver transplantation.Microvascular invasion and differentiation have been the most significant factors affecting post-transplant recurrence;however,because of inherent disadvantages of pre-transplant biopsy,histological criteria never gained popularity.Recently,the selection criteria evolved from morphological to biological criteria,such as biomarkers and response to loco-regional therapy.With the introduction of multimodality imaging,combination of computed tomography with nuclear medicine imaging,particularly,18F-fluorodeoxyglucose positron emission tomography fulfilled an unmet need and rapidly became a critical component of HCC management.This review article will focus on the use of 18F-fluorodeoxyglucose positron emission tomography combined with computed tomography in the pre-transplant evaluation of HCC patients with special discussion on its ability to predict HCC recurrence after liver transplantation. | Onur Yaprak Sencan Acar Gokhan Ertugrul Murat Dayangac | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 4 |
| 4 | Major complications of adult right lobe living liver donors显示文摘BACKGROUND:The right lobe of the liver is generally preferred for living donor liver transplantation in adult patients with end-stage liver disease.It is important to know the preoperative factors relating to the major postoperative complications.We therefore evaluated the possible risk factors for predicting postoperative complications in right lobe liver donors.METHODS:Data from 378 donors who had undergone | Necdet Guler Onur Yaprak Yusuf Gunay Murat Dayangac Murat Akyildiz Fisun Yuzer Yildiray Yuzer Yaman Tokat | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 3 |
| 5 | Living donor liver hilar variations: surgical approaches and implications显示文摘BACKGROUND: Varied vascular and biliary anatomies are common in the liver. Living donor hepatectomy requires precise recognition of the hilar anatomy. This study was undertaken to study donor vascular and biliary tract variations, surgical approaches and implications in living liver transplant patients. METHODS: Two hundred living donor liver transplantations were performed at our institution between 2004 and 2009. All donors were evaluated by volumetric computerized tomography (CT), CT angiography and magnetic resonance cholangiography in the preoperative period. Intraoperative ultrasonography and cholangiography were carried out. Arterial, portal and biliary anatomies were classified according to the Michels, Cheng and Huang criteria. RESULTS: Classical hepatic arterial anatomy was observed in 129 (64.5%) of the 200 donors. Fifteen percent of the donors had variation in the portal vein. Normal biliary anatomy was found in 126 (63%) donors, and biliary tract variation in 70% of donors with portal vein variations. In recipients with single duct biliary anastomosis, 16 (14.4%) developed biliary leak, and 9 (8.1%) developed biliary stricture; however more than one biliary anastomosis increased recipient biliary complications. Donor vascular variations did not increase recipient vascular complications. Variant anatomy was not associated with an increase in donor morbidity. CONCLUSIONS: Living donor liver transplantation provides information about variant hilar anatomy. The success of the procedure depends on a careful approach to anatomical variations. When the deceased donor supply is inadequate living donor transplantation is a life-saving alternative and is safe for the donor and recipient, even if the donor has variant hilar anatomy. | Onur Yaprak Tolga Demirbas Cihan Duran Murat Dayangac Murat Akyildiz Yaman Tokat Yildiray Yuzer | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 2 |
| 6 | Dual left lobe living donor liver transplantation using donors unacceptable for right lobe donation:a case report显示文摘 | Dayangac M Taner CB Akin B | 2010 | Transplant Proc2010，42，10： | 1 |
| 7 | Is permanentmaxillary tooth removal without palatal injection possible? 显示文摘 | Uckan S Dayangac E Araz K | 2006 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2006，102，6： | 1 |
| 8 | In vitro analysis of the effects of acid or laser etching on microleakage around composite resin restorations 显示文摘 | Ruiya Yazici A Frentzen M Dayangac B | 2001 | Journal of dentistry2001，29，： | 1 |
| 9 | Prenatal diagnosis of spinalmuscular atrophy in Turkish families显示文摘 | Erdem H Dayangac D PehlivanS | 2001 | Cent Eur J Public Health2001，9，1： | 1 |
| 10 | Alveolar distraction osteogenesis versus autogenous onlay bone grafting for alveolar ridge augmentation: Technique, complications, and implant sur- vival rates显示文摘 | UCKAN S VEZIROGLU F DAYANGAC E | 2008 | Oral Surg Oral Med Oral Pathol OralRadiol Endod2008，106，4： | 1 |
| 11 | A scanning electron microscopic study of different caries removal techniques on human dentin显示文摘 | Yazici AR Ozgunaltay G Dayangac B | | 0，，： | 1 |
| 12 | Prenatal diagnosis of spinal muscular atrophy in Turkish families显示文摘 | Erdem H Dayangac D Pehlivan S | 2001 | Cent Eur J Pubic Health2001，9，1： | 1 |
| 13 | Effects of Selenium with Vitamin E and Melatonin on Cadmium-Induced Oxidative Damage in Rat Liver and Kidneys显示文摘 | Haki Kara Ayd?n Cevik Vahit Konar Alpaslan Dayangac Kadir Servi | 2008 | Biological Trace Element Research2008，，3： | 1 |
| 14 | Prenatal diagnosis of spinal muscular atrophy in Turkish families显示文摘 | Erdem H Dayangac D Pehlivan S | 2001 | Cent Eur J Public Health2001，9，： | 1 |
| 15 | Vitamin D receptor gene polym - orphisms in Turkish children with vitamin D deficient rickets 显示文摘 | Bora G Ozkan B Dayangac - Erden D | 2008 | TurkJ Pediatr2008，50，1： | 1 |
| 16 | Evaluation of the effects of vitamin D receptor and estrogen receptor 1 gene polymorphisms on bone mineral density in postmenopausal women显示文摘 | Mine Durusu Tanriover Gamze Bora Tatar Tenzile Deniz Uluturk Didem Dayangac Erden Altug Tanriover Alpaslan Kilicarslan S. Gul Oz Hayat Erdem Yurter Tumay Sozen Gulay Sain Guven | 2010 | Clinical Rheumatology2010，，11： | 1 |
| 17 | Use of livers from hepatitis B core antibody positive donors in living donor liver transplantation显示文摘 | Yaprak O Dayangac M Balci D | 2010 | Hepatogastroenterology2010，57，102103： | 1 |
| 18 | Anatomical variations of donor portal vein in right lobe living donor liver transplantation: the safe use of variant portal veins 显示文摘 | Guler N Dayangac M Yaprak O | 2013 | Transpl Int2013，26，12： | 1 |
| 19 | Donor safety and remnant liver volume in living donor liver transplantation显示文摘 | TANER CB DAYANGAC M AKIN B | 2008 | Liver Transpl2008，14，8： | 1 |
| 20 | Prenatal diagnosis of spinal muscular atrophy in Tunkish families 显示文摘 | Erdem H Dayangac D PehlivanS etal | 2001 | Cent Eur J Public Health2001，9，1： | 1 |
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