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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | The solution of chemically modified cotton cellulose in alkaline solutions, Ⅰ: In solutions of sodium hydroxide particularly at temperatures below the normal 显示文摘 | Davidson G F | 1934 | Journal of Textile Institute1934，25，： | 1 |
| 3 | Effective rating scale development for speaking tests : Performance decision trees显示文摘 | Fulcher G Davidson F & Kemp J | 2011 | Language Testing2011，28，1： | 1 |
| 4 | A portable dual energy X-ray absorptiometry technique for the measurement of bone mineral in preterm infants显示文摘 | Williams JR Davidson F Menon G | 1994 | Pediatr Res1994，36，3： | 1 |
| 5 | Maize seed response to successive imbibition/dryback cycles:viability and vigor显示文摘 | Davidson K G V Sowa S Moore F D | 1994 | Seed Science research1994，，4： | 1 |
| 6 | Virus particles in epithelial cells of duodenal mucosa from children with acute nonbacterial gastroenteritisl显示文摘 | Bishop R F Davidson G P Holmes I H | 1973 | Lancet1973，2，： | 1 |
| 7 | The mechanics of spouted beds 显示文摘 | Lefroy G A Davidson J F | 1969 | Transactions of the Institution of Chemical English1969，47，1： | 1 |
| 8 | Bubble formation at an orifice in an inviscid liquid显示文摘 | Davidson J F Schtiler B O G | 1960 | Transactions of the Institution of Chemical Engineers1960，38，2： | 1 |
| 9 | Virus particles in epithelial cells of duodenal mucosa from children with acute non-bacterial gastroenteritis显示文摘 | Bishop R F Davidson G P Holmes I H | 1973 | Lancet1973，2，7841： | 1 |
| 10 | Benchmark concentrations for methyl mercury obtained from the 9-year follow-up of the Seychelles Child Development Study显示文摘 | van Wijngaarden D Beck C Shamlaye C F Cernichiari E Davidson P W Myerse G J Clarkson T W | 2006 | Neuro Toxicology2006，27，： | 1 |
| 11 | Acute gastritis occurring within 24 hours of severe head injury 显示文摘 | BROWN T H DAVIDSON P F LARSON G M | 1989 | Gastrointest Endosc1989，35，1： | 1 |
| 12 | Urinary free (uneon- jugated) metadrenalines in different hereditary forms of eate- eholamine-seereting phaeoehromoeytoma/paraganglioma显示文摘 | Davidson D F Bradshaw N Perry C G | 2012 | Ann Clin Bioehem2012，49，5： | 1 |
| 13 | Acute gastritis occurring within 24 hours of severe head injury显示文摘 | DAVIDSON P F LARSON G M | 1989 | Gastrointest Endosc1989，35，1： | 1 |
| 14 | Virus particles in ep- ithelial cells of duodenal mucosa from children with acute non-bac- terial gastroenteritis 显示文摘 | Bishop R F Davidson G P Hohnes I H | 1973 | Lancet1973，2，7841： | 1 |
| 15 | An enantioselective fluorescent sensor for sugar acids 显示文摘 | ZHAO J Z DAVIDSON M G MAHON M F | 2004 | J Am Chem Soc2004，26，16： | 1 |
| 16 | Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA显示文摘 | Pasquinelli A E Reinhart B J Slack F Martindale M Q Kuroda M I Maller B Hayward D C Ball E E Degnan B Müller P Spring J Srinivasan A Fishman M Finnerty J Corbo J Levine M Leahy P Davidson E and Ruvkun G | 2000 | Nature2000，408，6808： | 1 |
| 17 | Bubble formation at an orifice in an invisid liquid显示文摘 | DAVIDSON J F SCHUELER B O G | 1960 | Transactions of the Institution of Chemical Engineers1960，38，： | 1 |
| 18 | Reactivity of boranea with a titanium(Ⅳ) amine tris(phenolate) alkoxide complex; formation of a Ti(IV) tetrahydroborate complex, a Ti(Ⅲ) dimer and a Ti(Ⅳ) hydroxide Lewis acid adduct显示文摘 | JOHNSON A L DAVIDSON M G MAHON M F | 2007 | Dalton Trans2007，5405，： | 1 |
| 19 | Photoelasticity study of ice pressure in rock cracks显示文摘 | DAVIDSON G P NYE J F | 1985 | Cold Regions Science and Technology1985，11，2： | 1 |
| 20 | Conservation of the sequence and temporal expression of let-7 heterochronie regulatory RNA 显示文摘 | Pasquinelli AE Reinhart BJ Slack F Martindale MQ Kuroda MI Mallet B Hayward DC Ball EE Degnan B Miiller P Spring J Srinivasan A Fishman M Finnerty J Corbo J Levine M Leahy P Davidson E Ruvkun G | 2000 | Nature2000，408，6808： | 1 |
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