|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 2 | Financial in Corporate Finance:An Overview显示文摘 | | 1998 | Financial Management1998，，： | 1 |
| 3 | Challenges for psy-chiatry in serving homeless people with psychiatric disorders 显示文摘 | Mcquistion HL Finnerty Hisrchowitz J | 2003 | Psychiatric Services2003，54，： | 1 |
| 4 | The miR - 15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases显示文摘 | FINNERTY J R WANG W X HI'BERT S S | 2010 | J Mol Biol2010，402，3： | 1 |
| 5 | Ipsilateral transversus abdominis plane block provides effective analgesia after appendectomy in children:A randomized controlled trial显示文摘 | Carney J Finnerty O Rauf J | 2010 | Anesth Analg2010，111，4： | 1 |
| 6 | Insiders' activity and inside information : A multivariate analysis显示文摘 | Finnerty J E | 1976 | Journal of Financial and Quantitative Analysis1976，11，： | 1 |
| 7 | Comparative Analysis of the Lipids of Acinetobacter Species Grown on Hexadecane显示文摘 | Makula R A Lockwood P J Finnerty W R | 1975 | Journal of bacteriology1975，121，1： | 1 |
| 8 | Electronic structure methods applied to gas-carbon reactions显示文摘 | Zhu Zhonghua Lu G Q Finnerty J | 2003 | Carbon2003，41，4： | 1 |
| 9 | Electronic structure methods applied to gas-carbon reactions显示文摘 | Zhu Z H Lu G Q Finnerty J | 2003 | Carbon2003，41，4： | 1 |
| 10 | A comparative study of carbon gasification with 02 and CO2 by density functional theory calculations 显示文摘 | Zhu Z H Finnerty J lax G Q ctal | 2002 | Energy & Fuels2002，16，6： | 1 |
| 11 | Smad ubiquitinationregulatory factor 2 expression is enhanced in hypertrophicscar fibroblasts from burned children显示文摘 | ZHANG Z FINNERTY C C HE J | 2012 | Bums2012，38，2： | 1 |
| 12 | Scale dependencies of hydrologic models to spatial variability of precipitation 显示文摘 | Koren V I Finnerty B D Schaake J C | 1999 | Journal of Hydrology1999，217，： | 1 |
| 13 | Financial engineering in corporate finance: an overview显示文摘 | Finnerty J D | 1988 | Finance Management1988，17，： | 1 |
| 14 | Carbon formation on and deactivation of nickel-based/zirconia anodes in solid oxide fuel cells running on methane 显示文摘 | Finnerty C M Coe N J Cunningham R H | 1998 | Catalysis Today1998，46，2： | 1 |
| 15 | Studies on the spread of local anesthetic solution in transversus abdominis plane blocks 显示文摘 | Earney J Finnerty O Rauf J | 2011 | Anaesthsia2011，66，11： | 1 |
| 16 | The prohormone convertase enzyme2(PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site显示文摘 | Wan J Xu J Finnerty J | 2001 | Diabetes2001，50，3： | 1 |
| 17 | ,Insiders and market efficiency显示文摘 | finnerty J | 1976 | Journal of Finance1976，31，： | 1 |
| 18 | Long-term effects of furosemide and hydrochlorothiazide in patients with essential hypertension:A two-year comparison of efficacy and safety显示文摘 | Finnerty FA Maxwell MH Lunn J | 1977 | Angiology1977，28，： | 1 |
| 19 | Gated blood-pool SPECT versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction 显示文摘 | Harel F Finnerty V Gregoire J | 2010 | J Nucl Cardiol2010，17，3： | 1 |
| 20 | Severe injury is associat-ed with insulin resistance, endoplasmic reticulum stressresponse,and unfolded protein response显示文摘 | Jeschke M G’Finnerty C C Herndon D N Song J Boe-hning D Tompkins R G | 2012 | Ann Surg2012，255，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员