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| 1 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 2 | Presentation matters: Identity of gold nanocluster capping agent governs intracellular uptake and cell metabolism显示文摘 | Chor Yong Tay Yong Yu Magdiel Inggrid Setyawati Jianping Xie David Tai Leong | 2014 | Nano Research2014，7，6： | 3 |
| 3 | Observing antimicrobial process with traceable gold nanodusters显示文摘Understanding the interaction of nanomaterials with biological systems has always been of high concern and interest.An emerging type of nanomaterials,ultrasmall metal nanoclusters(NCs,<2 nm in size),are promising in this aspect due to their well-defined molecular formulae and structures,as well as unique physical and chemical properties that are distinctly different from their larger counterparts(metal nanoparticles).For example,metal NCs possess intrinsic strong luminescence,which can be used for real-time tracking of their interactions with biological systems.Herein,luminescent gold(Au)NCs were used as traceable antimicrobial agents to study their interactions with the bacteria and tofurther understand their underlining antimicrobial mechanism.It is shown for the first time that the Au NCs would first attach on the bacterial membrane,penetrate,and subsequently accumulate inside the bacteria.Thereafter,the internalized Au NCs would induce reactive oxygen species(ROS)generation and damage the bacterial membrane,resulting in the leakage of bacterial contents,which can finally kill the bacteria.Traceable Au NCs(or other metal NCs)provide a promising platform to study the antimicrobial mechanisms as well as other fundamentals on the interfacing of functional nanomaterials with the biological systems,further increasing their acceptance in various biomedical applications. | Kaiyuan Zheng Magdiel I.Setyawati David Tai Leong Jianping Xie | 2021 | Nano Research2021，14，4： | 2 |
| 4 | Formanilide and carbanilide from aniline and carbon dioxide 显示文摘 | Munshi Pradip Heldebrant David J McKoon Erin P Kelly Patrick A Tai Chih-Cheng Jessop Philip G | 2003 | Tetrahedron Letters2003，44，： | 1 |
| 5 | A randomized controlled trial of stage‐matched intervention for smoking cessation in cardiac out‐patients显示文摘 | Sophia S. C.Chan Doris Y. P.Leung David C. N.Wong Chu‐PakLau Vivian T.Wong Tai‐HingLam | 2012 | Addiction2012，，4： | 1 |
| 6 | Httperf-A tool for measuring Web server performance显示文摘 | DAVID M TAI Jin | 1998 | ACM SIGMETRICS Performance Evaluation Review1998，26，3： | 1 |
| 7 | Hypoxia and adrenergic function: Molecular mechanisms related to Egr-1 and Sp1 activation显示文摘 | T.C. Tai David C. Wong-Faull Robert Claycomb Dona L. Wong | 2010 | Brain Research2010，，： | 1 |
| 8 | The role of the primary visual cortex in higher level vision显示文摘 | Tai Sing Lee David Mumford Richard Romero Victor A.F. Lamme | 1998 | Vision Research1998，，15： | 1 |
| 9 | Human resource strategy and firm performance in Pacific Rim countries 显示文摘 | Bea J Shrh-Jer Chen Tai Wai David Wan | 2003 | International Journal of Human Resource Management2003，14，8： | 1 |
| 10 | Ethanol extract of Fructus Ligustri Lucidi promotes osteogenesis of mesenchymal stem cells显示文摘 | GuoLi Xiao‐aiZhang Jin‐fangZhang Chu‐yanChan David Tai WaiYew Ming‐liangHe Marie Chia‐miLin Ping‐chungLeung Hsiang‐fuKung | 2010 | Phytother Res2010，，4： | 1 |
| 11 | Postoperative day one serum alanine aminotransferase does not predict patient morbidity and mortality after elective liver resection in non-cirrhotic patients显示文摘Serum aminotransferases have been used as surrogate markers for liver ischemia-reperfusion injury that follows liver surgery. Some studies have suggested that rises in serum alanine aminotransferase(ALT) correlate with patient outcome after liver resection. We assessed whether postoperative day 1(POD 1) ALT could be used to predict patient morbidity and mortality following liver resection. We reviewed our prospectively held database and included consecutive adult patients undergoing elective liver resection in our institution between January 2013 and December 2014. Primary outcome assessed was correlation of POD 1 ALT with patient's morbidity and mortality. We also assessed whether concurrent radiofrequency ablation, neoadjuvant chemotherapy and use of the Pringle maneuver significantly affected the level of POD 1 ALT. A total of 110 liver resections were included in the study. The overall in-hospital patient morbidity and mortality were 31.8% and 0.9%, respectively. The median level of POD 1 ALT was 275 IU/L. No correlation was found between POD 1 serum ALT levels and patient morbidity after elective liver resection, whilst correlation with mortality was not possible because of the low number of mortalities. Patients undergoing concurrent radiofrequency ablation were noted to have an increased level of POD 1 serum ALT but not those given neoadjuvant chemotherapy and those in whom the Pringle maneuver was used. Our study demonstrates POD 1 serum ALT does not correlate with patient morbidity after elective liver resection. | Ricky Harminder Bhogal Amit Nair Davide Papis Zaed Hamady Jawad Ahmad For Tai Lam Saboor Khan Gabriele Marangoni | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 1 |
| 12 | The role of the primary visual cortex in higher level vision显示文摘 | Tai Sing Lee David Mumford Richard Romero Victor A.F. Lamme | 1998 | Vision Research1998，，15： | 1 |
| 13 | Formanilide and carbanilide from aniline and carbon dioxide显示文摘 | Pradip Munshi David J. Heldebrant Erin P. McKoon Patrick A. Kelly Chih-Cheng Tai Philip G. Jessop | 2003 | Tetrahedron Letters2003，，13： | 1 |
| 14 | High-dose tamoxifen in the treatment of inoperable hepatocellular carcinoma: A multicenter randomized controlled trial显示文摘 | Pierce K.H. Chow Bee-Choo Tai Chee-Kiat Tan David Machin Khin Maung Win Phillip J. Johnson Khee-Chee Soo | 2002 | Hepatology2002，，5： | 1 |
| 15 | Httperf-a tool for measuring web server performance显示文摘 | David Mosberger Tai Jin | 1998 | ACM Sigmetrics Performance Evaluation Review1998，26，3： | 1 |
| 16 | Anti-migratory and increased cytotoxic effects of novel dual drug-loaded complex hybrid micelles in triple negative breast cancer cells显示文摘基于聚合物的 nanocarrier 为 epigenetic 和化学疗法的药的合作交货被开发。位地稳定的混合 micelle 系统使用微粒 D 创作了 -- tocopheryl 聚乙烯乙二醇 1000 succinate (维生素 E TPGS 或 TPGS ) 和 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (聚乙烯乙二醇)-2000](DSPE-PEG2000 ) 。在这研究, suberoylanilide hydroxamic 酸(SAHA ) 和 paclitaxel 被用作模型药让联合化疗在指向像间充组织的三倍的否定乳癌(TNBC ) 提高治疗学的效率房间。在一个双药 micelle 系统的 paclitaxel 和 SAHA 的联合治疗,(P + S ) mic , 展出了 0.52 g/mL 的 IC50 值,它关于比免费的药(P + S ) 的仅仅的联合更细胞毒素的 5.91 褶层。而且,(P + S ) mic 明确的表达在比控制由超过 3.4 褶层禁止房间移植是更加有效的。因此,我们用 micelle 系统的这些药的合作交货极大地提高的调查结果表演他们在更低的剂量的治疗学的效果,从而最小化毒性。另外,这明确的表达被证明在在低剂量阻止房间移植显著地有效。 | Rajaletchumy Veloo Kutty Chor Yong Tay Chen Siew Lim Si-Shen Feng David Tai Leong | 2015 | Nano Research2015，8，8： | 1 |
| 17 | Molecular and Other Novel Advances inTreatment of Metastatic Epithelial and Medullary Thyroid Cancers 显示文摘 | David Tai Donald Poon | 2010 | Oncologv2010，24，： | 1 |
| 18 | Potent antitumor activity of cabozantinib, a c‐ MET and VEGFR 2 inhibitor, in a colorectal cancer patient‐derived tumor explant model显示文摘 | Eun‐Kee Song WM Tai Wells A. Messersmith Stacey Bagby Alicia Purkey Kevin S. Quackenbush Todd M. Pitts Guoliang Wang Patrick Blatchford Rachel Yahn Jeffrey Kaplan Aik Choon Tan Chloe E. Atreya Gail Eckhardt Robin K. Kelley Alan Venook Eunice L. Kwak David | 2015 | Int. J. Cancer2015，，8： | 1 |
| 19 | Minimum Quantity Lubrication (MQL) in Automotive Powertrain Machining 显示文摘 | Bruce L Tai David A Stephenson Richard J Furness | 2014 | 6th CIRP International Confer- ence on High Performance Cutting2014，14，： | 1 |
| 20 | Pharmacological Abrogation of S-Phase Checkpoint Enhances the Anti-Tumor Activity of Gemcitabine In Vivo显示文摘 | David J. Matthews Michael Yakes Jason Chen Michele Tadano Lester Bornheim Douglas O. Clary Albert Tai Jill M. Wagner Nicole Miller Yong D. Kim Scott Robertson Louis Murray Larry M. Karnitz | 2007 | Cell Cycle2007，，1： | 1 |
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