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| 1 | Perfusion magnetic resonance imaging of the liver显示文摘Perfusion magnetic resonance imaging (MRI) studies quantify the microcirculatory status of liver parenchyma and liver lesions, and can be used for the detection of liver metastases, assessing the effectiveness of antiangiogenic therapy, evaluating tumor viability after anticancer therapy or ablation, and diagnosis of liver cirrhosis and its severity. In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and evidence that supports its use from published clinical and research studies. Technical standardization and further studies will help to establish and validate perfusion MRI as a clinical imaging modality. | Choon Hua Thng Tong San Koh David J Collins Dow Mu Koh | 2010 | World Journal of Gastroenterology2010，16，13： | 15 |
| 2 | A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province,China显示文摘Background:Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks.An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years.There was a large acute gastroenteritis outbreak at a university in Henan Province,China in the past five years.We want to identify the source,transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures.Methods:The clinical cases were investigated,and analysed by descriptive epidemiological methods according to factors such as time,department,grade and so on.Samples were collected from clinical cases,healthy persons,the environment,water,and food at the university.These samples were tested for potential bacteria and viruses.The samples that tested positive for norovirus were selected for whole genome sequencing and the sequences were then analysed.Results:From 4 March to 3 April 2015,a total of 753 acute diarrhoea cases were reported at the university;the attack rate was 3.29%.The epidemic curve showed two peaks,with the main peak occurring between 10 and 20 March,accounting for 85.26%of reported cases.The rates of norovirus detection in samples from confirmed cases,people without symptoms,and environmental samples were 32.72%,17.39%,and 9.17%,respectively.The phylogenetic analysis showed that the norovirus belonged to the genotype GII.17.Conclusions:This is the largest and most severe outbreak caused by genotype GII.17 norovirus in recent years in China.The GII.17 viruses displayed high epidemic activity and have become a dominant strain in China since the winter of 2014,having replaced the previously dominant GII.4 Sydney 2012 strain. | Xue-Yong Huang Jia Su Qian-Chao Lu Shi-Zheng Li Jia-Yong Zhao Meng-Lei Li Yi Li Xiao-Jing Shen Bai-Fan Zhang Hai-Feng Wang Yu-Jiao Mu Shu-Yu Wu Yan-Hua Du Li-Cheng Liu Wei-Jun Chen John David Klena Bian-Li Xu | 2017 | Infectious Diseases of Poverty2017，6，1： | 10 |
| 3 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 3 |
| 4 | Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients显示文摘BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was conducted.CHC patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array assays.Differences were validated by the Kruskal-Wallis and Mann-Whitney U tests.The Spearman correlation coefficient and area under the receiver operating characteristic curve were calculated.Collagenolytic and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot assays.RESULTS Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy subjects.MMP-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis stage.Tissue inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis progression.MMPs could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC. | Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes | 2021 | World Journal of Hepatology2021，13，2： | 2 |
| 5 | IL-6 and IGF-1 are Independent Prognostic Factors of Liver Steatosis and Non-Alcoholic Steatohepatitis in Morbidly Obese Patients显示文摘 | David García-Galiano Miguel A. Sánchez-Garrido Isabel Espejo José Luis Montero Guadalupe Costán Trinidad Marchal Antonio Membrives José M. Gallardo-Valverde Juan R. Mu?oz-Casta?eda Eugenio Arévalo Manuel Mata Jordi Muntané | 2007 | Obesity Surgery2007，，： | 2 |
| 6 | The Nature and Growth of Vertical Specialization in World Trade 显示文摘 | Hummels David Jun Ishii and Kei- Mu Yi | | Journal of0，，： | 1 |
| 7 | Vertical Specialization and the Changing Nature of World Trade 显示文摘 | David Hummels Dana Rapoport Kei - mu | 1998 | Economic Policy Review1998，，6： | 1 |
| 8 | The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking显示文摘 | Karel F. Liem Alyson Ashe Mu He Peter Satir Jennifer Moran David Beier Carol Wicking Kathryn V. Anderson | 2012 | The Journal of Cell Biology2012，，6： | 1 |
| 9 | The Natrue and Growth of Vertical Specialization in World Trade 显示文摘 | David Hummels Ishii Jun Kei -mu Yi | 2001 | Journal of International economics2001，，1： | 1 |
| 10 | Vertical Specialization and the (Ynanging Nature of World Trade显示文摘 | David Hummels Dana Rapoport Kei - mu | 1998 | Economic Policy Review1998，，6： | 1 |
| 11 | The nature and growth of vertical specialization in world 显示文摘 | David Hummels Jun Ishii Kei - Mu Yi | 2001 | International Economics2001，54，1： | 1 |
| 12 | Nanoparticle-based monitoring of cell therapy显示文摘 | Chenjie Xu Luye Mu Isaac Roes David Miranda-Nieves Matthias Nahrendorf James A Ankrum Weian Zhao Jeffrey M Karp | 2011 | Nanotechnology2011，，49： | 1 |
| 13 | Detección del shunt intrapulmonar en pacientes con cirrosis hepática mediante doppler transcraneal con contraste. Estudio de prevalencia, caracterización del patrón y validez diagnóstica显示文摘 | José María Ramírez Moreno María Victoria Millán Nú?ez Marta Rodríguez Carrasco David Ceberino Olena Romaskevych-Kryvulya Ana Belén Constantino Silva Pedro Mu?oz-Vega Carmen García-Corrales Ana Guiberteau-Sánchez Ana Roa Montero Patricia Márquez-Lozano Isi | 2015 | Gastroenterologia y Hepatologia2015，，8： | 1 |
| 14 | Toll-like receptors: key mediators of microbe detection显示文摘 | David MU Adrian O | 2002 | Curr Opin In Immunol2002，14，： | 1 |
| 15 | The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers显示文摘 | Michal Cohen‐Eliav Regina Golan‐Gerstl Zahava Siegfried Claus L Andersen Kasper Thorsen Torben F ?rntoft David Mu Rotem Karni | 2013 | J Pathol2013，，4： | 1 |
| 16 | The nature and growth of vertical specialization in world trade 显示文摘 | Hummels David Ishii Jun Kei - Mu Yi | 2001 | Journal of International Economics2001，54，： | 1 |
| 17 | Vertical Specialization and the Changing Nature of World Trade 显示文摘 | Hummels David Rapoport Dana and Yi Kei - Mu | 1998 | Federal Reserve Bank of New York Economic Policy Renew1998，4，2： | 1 |
| 18 | 'The Nature and Growth of Vertical Specialization in World Trade' 显示文摘 | Hummels David Jun Ishii and Kei- Mu Yi | 2001 | Journal of International Economics2001，54，6： | 1 |
| 19 | The Nature and Growth of Vertical Specialization in World Trade显示文摘 | Hummels David Jun Ishii Kei- Mu Yi | 2001 | Journal of International Economics2001，54，： | 1 |
| 20 | Molecular detection and prognostic value of epithelial markersmRNA expression in peripheral blood of advanced non-small cell lung cancer patients显示文摘 | Oscar Arrieta Benjamí n Pineda Saé Mu? iz-Herná ndez Diana Flores Graciela Ordó ? ez Jose R. Borbolla-Escoboza David Orta | 2014 | Cancer Biomarkers2014，，4： | 1 |
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