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| 1 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 2 | Effects of Construction Noise on Behavior and Cortisol Levels in a Pair of Captive Giant Pandas (Ailuropoda melanoleuca)显示文摘 | David M Powell Kathy Carlstead Loraine R Tarou | 2006 | Zoo Biology2006，25，： | 1 |
| 3 | Overview of the CALIPSO Mission and CALIOP Data Processing Algorithms显示文摘 | Winker David M Vaughan Mark A Omar Ali Hu Yongxiang Powell Kathleen A Liu Zhaoyan Hunt William H Young Stuart A | 2009 | Journal of Atmospheric and Oceanic Technology2009，，11： | 1 |
| 4 | Medication beliefs predict medication adherence in ambulatory patients with decompensated cirrhosis显示文摘AIM To investigate the impact of medication beliefs, illness perceptions and quality of life on medication adherence in people with decompensated cirrhosis.METHODS One hundred adults with decompensated cirrhosis completed a structured questionnaire when they attended for routine outpatient hepatology review. Measures of self-reported medication adherence(Morisky Medication Adherence Scale), beliefs surrounding medications(Beliefs about Medicines Questionnaire), perceptions of illness and medicines(Brief Illness Perception Questionnaire), and quality of life(Chronic Liver Disease Questionnaire) were examined. Clinical data were obtained via patient history and review of medical records. Least absolute shrinkage and selection operator and stepwise backwards regression techniques were used to construct the multivariable logistic regression model. Statistical significance was set at alpha = 0.05.RESULTS Medication adherence was ' High ' in 42 % o f participants, 'Medium' in 37%, and 'Low' in 21%. Compared to patients with 'High' adherence, those with 'Medium' or 'Low' adherence were more likely to report difficulty affording their medications(P < 0.001), lower perception of treatment helpfulness(P = 0.003) and stronger medication concerns relative to medication necessity beliefs(P = 0.003). People with 'Low' adherence also experienced greater symptom burden and poorer quality of life, including more frequent abdominal pain(P = 0.023), shortness of breath(P = 0.030), and emotional disturbances(P = 0.050). Multivariable analysis identified having stronger medication concerns relative to necessity beliefs(Necessity-Concerns Differential ≤ 5, OR = 3.66, 95%CI: 1.18-11.40) and more frequent shortness of breath(shortness of breath score ≤ 3, OR = 3.87,95%CI: 1.22-12.25) as independent predictors of 'Low'adherence.CONCLUSION The association between 'Low' adherence and patients having strong concerns or doubting the necessity or helpfulness of their medications should be explored further given the clinical relevance. | Kelly L Hayward Patricia C Valery Jennifer H Martin Antara Karmakar Preya J Patel Leigh U Horsfall Caroline J Tallis Katherine A Stuart Penny L Wright David D Smith Katharine M Irvine Elizabeth E Powell W Neil Cottrell | 2017 | World Journal of Gastroenterology2017，23，40： | 1 |
| 5 | Late Miocene and mid-Pliocene enhancement of the East Asian monsoon as viewed from the land and sea 显示文摘 | ZHENG H B POWELL C M DAVID K R | 2004 | Global and Planetary change2004，41，： | 1 |
| 6 | Effects of Construction Noise on Behavior and ortisol Levels in a Pair of Captive Giant Pandas (Ailuropoda melanoleuca)显示文摘 | David M Powell Kathy C.Loraine R.Tarou | | 0，，： | 1 |
| 7 | Outcome of Reproductive Age Women with Stage IA or IC Invasive Epithelial Ovarian Cancer Treated with Fertility-Sparing Therapy显示文摘 | Jeanne M Schilder Amy M Thompson Paul D DePriest Frederick R Ueland Michael L Cibull Richard J Kryscio Susan C Modesitt Karen H Lu John P Geisler Robert V Higgins Paul M Magtibay David E Cohn Matthew A Powell Christina Chu Frederick B Stehman John van Nag | 2002 | Gynecologic Oncology2002，，： | 1 |
| 8 | Bleeding in congenital hemangiomas:crusting as a clinical predictive sign and usefulness of tranexamic acid显示文摘 | Powell J Blouin MM David M | 2012 | Pediatr Dermatol2012，29，2： | 1 |
| 9 | Cediranib combined with carboplatin and paclitaxel in patients with metastatic or recurrent cervical cancer (CIRCCa): a randomised, double-blind, placebo-controlled phase 2 trial显示文摘 | R Paul Symonds Charlie Gourley Susan Davidson Karen Carty Elaine McCartney Debbie Rai Susana Banerjee David Jackson Rosemary Lord Mary McCormack Emma Hudson Nicholas Reed Maxine Flubacher Petra Jankowska Melanie Powell Caroline Dive Catharine M L West Jam | 2015 | The Lancet Oncology2015，，15： | 1 |
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