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3篇 您的检索式:作者名="David Escors"
    题名 作者 年代 出处 被引量
1Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential显示文摘David Escors Karine Breckpot 2010Archivum Immunologiae et Therapiae Experimentalis2010,,2:1
2DNA fusion vaccine designs to induce tumor‐lytic CD8+ T‐cell attack via the immunodominant cysteine‐containing epitope of NY‐ESO 1显示文摘Juan Campos‐Perez Jason Rice David Escors Mary Collins Alex Paterson Natalia Savelyeva Freda K. Stevenson 2013Int J Cancer2013,,6:1
3The intracellular signalosome of PD-L1 in cancer cells显示文摘Programmed cell death-1 ligand-1(PD-L1)overexpression in cancer cells accelerates tumor progression.PD-L1 possesses two main pro-oncogenic functions.First,PD-L1 is a strong immunosuppressive molecule that inactivates tumor-specific T cells by binding to the inhibitory receptor PD-1.Second,PD-L1 function relies on the delivery of intrinsic intracellular signals that enhance cancer cell survival,regulate stress responses and confer resistance toward pro-apoptotic stimuli,such as interferons.Here,we review the current knowledge on intracellular signal transduction pathways regulated by PD-L1,describe its associated signalosome and discuss potential combinations of targeted therapies against the signalosome with PD-L1/PD-1 blockade therapies.David Escors Maria Gato-Canas Miren Zuazo Hugo Arasanz María Jesus García-Granda Ruth Vera Grazyna Kochan 2018Signal Transduction and Targeted Therapy2018,3,1:0
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