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| 1 | 转录因子Sp1在胃癌组织中的表达及其与胃癌预后的关系显示文摘目的探讨转录因子Sp1在胃癌组织中的表达情况及与胃癌患者预后的关系。方法采用免疫组化方法,检测Sp1在86例胃癌组织、53例淋巴结转移灶和57例正常胃黏膜组织中的表达情况,利用凝胶电泳迁移率分析(EMSA)检测正常胃黏膜组织和胃癌组织中的Sp1活性。应用Cox比例风险回归模型进行多因素分析,确立影响预后的独立因素。结果Sp1蛋白主要在黏液颈细胞胞核内表达,在胃小凹和腺上皮细胞中未见表达。同时,SP1在胃癌组织中高表达,而在胃癌邻近组织、胃癌间质细胞和腺体细胞中呈弱表达或无表达。在胃癌组织中,Sp1阴性表达、弱表达和高表达患者的中位生存时间分别为43个月、47个月和8个月,生存率差异有统计学意义(P<0.01)。多因素分析显示,Sp1表达、肿瘤分期是影响患者预后的独立因素。结论Sp1在胃癌组织中高表达,可作为预测胃癌患者预后的重要指标。 | 王理伟 李琦 华召来 周翡 Keping Xie Daoyan Wei James Yao Jaffer Ajani | 2007 | 中华肿瘤杂志2007，29，2： | 10 |
| 2 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 3 | Direct demonstration of negative regulation of tumor growth and metastasis by host-inducible nitric oxide synthasel显示文摘 | Daoyan Wei Erica L Richardson | 2005 | Cancer Res2005，63，5： | 1 |
| 4 | Genome-Wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer显示文摘 | Zhihai Peng Fang Zhang Chongzhi Zhou Yun Ling Shaochun Bai Wanqing Liu Guoqiang Qiu Lin He Liwei Wang Daoyan Wei Edward Lin Keping Xie | 2003 | International Journal of Gastrointestinal Cancer2003，，1： | 1 |
| 5 | A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer显示文摘 | Yixing Jiang Liwei Wang Weida Gong Daoyan Wei Xiangdong Le James Yao Jaffer Ajani James L. Abbruzzese Suyun Huang Keping Xie | 2005 | Clinical & Experimental Metastasis2005，，8： | 1 |
| 6 | RUNX3 Inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer显示文摘 | Peng Zhihai Wei Daoyan Wang Liwei | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 7 | Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice显示文摘 | Qiang Li Zhiliang Jia Li Wang Xiangyu Kong Qi Li Kun Guo Dongfeng Tan Xiangdong Le Daoyan Wei Suyun Huang Lopa Mishra Keping Xie | 2012 | Gastroenterology2012，，3： | 1 |
| 8 | Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer显示文摘 | Jun Zhang Yixing Jiang Zhiliang Jia Qiang Li Weida Gong Liwei Wang Daoyan Wei James Yao Shengyun Fang Keping Xie | 2006 | 2006 (7-8)2006，，7： | 1 |
| 9 | RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer显示文摘 | Peng Zhihai Wei Daoyan Wang Liwei | 2006 | Clin Cancer Res2006，12，21： | 1 |
| 10 | Loss of RUNX3 expression significantly affects the clinical outcome of gastric cancer patients and its restoration causes drastic suppression of tumor growth and metastasis显示文摘 | Wei Daoyan Gong Weida Oh SC | 2005 | Cancer Res2005，65，11： | 1 |
| 11 | Star3 activation regulates the expression of vascular endothelial growth factor and hmnan pancreatic cancer angiogenesis and metastasis 显示文摘 | Daoyan Wei Xiangdong Le Leizhen Zheng | 2003 | Oncogene2003，22，： | 1 |
| 12 | Celecoxib Inhibits Vascular Endothelial Growth Factor Expression and Reduces Angiogenesis and Metastasis of Human Pancreatic Cancer via Suppression of Spl Transcription Factor Activity 显示文摘 | Daoyan Wei Liwei Wang Yanjuan He | 2004 | Cancer reserch2004，15，64： | 1 |
| 13 | Altered Expression of Transcription Factor Sp1 Critically Impacts the Angiogenic Phenotype of Human Gastric Cancer显示文摘 | 王理伟 GUAN Xiaohong GONG Weida YAO James PENG Zhihai WEI Daoyan WU Tsung - Teh HUANG Suyun XIE Keping | 2006 | 同济大学学报(医学版)2006，27，5： | 1 |
| 14 | 盐摄入通过PPARδ/脂联素介导的SGLT2通路调控糖稳态显示文摘高盐摄入是糖尿病发生高血压的主要危险因素.促进肾脏盐排泄可减少糖尿病的心血管损害,但摄盐与糖稳态的相互作用尚不清楚。 | Yu Zhao Peng Gao Fang Sun Qiang Li Jing Chen Hao Yu Li Li Xing Wei Hongbo He Zongshi Lu Xiao Wei Bin Wang Yuanting Cui Shiqiang Xiong Qianhui Shang Aimin Xu Yu Huang Daoyan Liu 祝之明 | 2017 | 科学新闻2017，19，4： | 0 |
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